Paul Grimsrud | Scholars@Duke

Paul Grimsrud
Assistant Professor in Medicine

Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2021
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2020

Contact Information

104775, Durham, NC 27701
300 N Duke Street, 48-208K, Durham, NC 27701
paul.grimsrud@duke.edu (919) 684-0631
Duke Endocrinology Basic Science Research
Duke Molecular Physiology Institute Faculty
LinkedIn
Twitter

Background
Education, Training, & Certifications
- Ph.D., University of Minnesota, Twin Cities 2008
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2020
Leadership & Clinical Positions at Duke
- Proteomics Section Leader, Duke Molecular Physiology Institute
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience awarded by National Institutes of Health 2022 - 2027
- The Role of ChREBP in Fructose Induced Metabolic Disease awarded by National Institutes of Health 2014 - 2024
- Mechanisms of lipid-induced bioenergetic stress in muscle awarded by National Institutes of Health 2010 - 2023
- Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2021 - 2022
- Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism awarded by National Institutes of Health 2018 - 2022
- NCDRC P&F April 2021 awarded by Wake Forest University 2021 - 2022
- AHA Career Development Award awarded by American Heart Association 2018 - 2021
- Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2017 - 2021
- Mitochondrial Protein Acetylation and Energy Metabolism in Muscle awarded by National Institutes of Health 2015 - 2018
- Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2017
- Novel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of Aging awarded by National Institutes of Health 2016 - 2017
- Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by Sanford-Burnham Medical Research Institute 2017
Fellowships, Supported Research, & Other Grants
- Borden Scholars Award awarded by Duke University School of Medicine 2022 - 2023
- Career Development Award (18CDA34110216) awarded by American Heart Association 2018 - 2021
- Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship (1F32DK091049-01A1) awarded by National Institutes of Health/ National Institute of Diabetes and Digestive and Kidney Diseases 2011 - 2014
- Institutional National Research Service Award (2T32HL007741-11) awarded by National Institutes of Health/National Heart, Lung, and Blood Institute 2004 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lyons, Scott P., Rebecca J. Wilson, Deborah M. Muoio, and Paul A. Grimsrud. “Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model.” Data Brief 42 (June 2022): 108051. https://doi.org/10.1016/j.dib.2022.108051.
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  - Trub, Alec G., Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J Will Thompson, Olga R. Ilkayeva, et al. “Statin therapy inhibits fatty acid synthase via dynamic protein modifications.” Nature Communications 13, no. 1 (May 10, 2022): 2542. https://doi.org/10.1038/s41467-022-30060-w.
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  - Bhatt, Dhaval P., C Allie Mills, Kristin A. Anderson, Bárbara J. Henriques, Tânia G. Lucas, Sara Francisco, Juan Liu, et al. “Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.” J Biol Chem 298, no. 4 (April 2022): 101723. https://doi.org/10.1016/j.jbc.2022.101723.
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  - Wilson, Rebecca J., Scott P. Lyons, Timothy R. Koves, Victoria G. Bryson, Hengtao Zhang, TianYu Li, Scott B. Crown, et al. “Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass.” Mol Metab 57 (March 2022): 101429. https://doi.org/10.1016/j.molmet.2021.101429.
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  - Williams, Ashley S., Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, and Deborah M. Muoio. “Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.” Iscience 25, no. 1 (January 21, 2022): 103635. https://doi.org/10.1016/j.isci.2021.103635.
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  - Bareja, Akshay, James A. Draper, Lauren H. Katz, David E. Lee, Paul A. Grimsrud, and James P. White. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev 195 (April 2021): 111443. https://doi.org/10.1016/j.mad.2021.111443.
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  - Mills, Christine A., Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, and Michael J. Emanuele. “Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.” Mol Cell Biol 41, no. 2 (January 25, 2021). https://doi.org/10.1128/MCB.00269-20.
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  - Davidson, Michael T., Paul A. Grimsrud, Ling Lai, James A. Draper, Kelsey H. Fisher-Wellman, Tara M. Narowski, Dennis M. Abraham, Timothy R. Koves, Daniel P. Kelly, and Deborah M. Muoio. “Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.” Circ Res 127, no. 8 (September 25, 2020): 1094–1108. https://doi.org/10.1161/CIRCRESAHA.120.317293.
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  - Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.
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  - Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.
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  - Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.
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  - Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.
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  - White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.
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  - Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.
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  - Wagner, Gregory R., Dhaval P. Bhatt, Thomas M. O’Connell, J Will Thompson, Laura G. Dubois, Donald S. Backos, Hao Yang, et al. “A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.” Cell Metab 25, no. 4 (April 4, 2017): 823-837.e8. https://doi.org/10.1016/j.cmet.2017.03.006.
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  - Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metabolism 25, no. 4 (April 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.
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  - McDonnell, Eoin, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, and Matthew D. Hirschey. “Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.” Cell Rep 17, no. 6 (November 1, 2016): 1463–72. https://doi.org/10.1016/j.celrep.2016.10.012.
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  - Davies, Michael N., Lilja Kjalarsdottir, J Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, and Deborah M. Muoio. “The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.” Cell Rep 14, no. 2 (January 12, 2016): 243–54. https://doi.org/10.1016/j.celrep.2015.12.030.
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  - Dingley, Stephen D., Erzsebet Polyak, Julian Ostrovsky, Satish Srinivasan, Icksoo Lee, Amy B. Rosenfeld, Mai Tsukikawa, et al. “Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.” J Mol Biol 426, no. 11 (May 29, 2014): 2199–2216. https://doi.org/10.1016/j.jmb.2014.02.009.
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  - Still, Amelia J., Brendan J. Floyd, Alexander S. Hebert, Craig A. Bingman, Joshua J. Carson, Drew R. Gunderson, Brendan K. Dolan, et al. “Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.” J Biol Chem 288, no. 36 (September 6, 2013): 26209–19. https://doi.org/10.1074/jbc.M113.483396.
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  - Grimsrud, Paul A., Joshua J. Carson, Alex S. Hebert, Shane L. Hubler, Natalie M. Niemi, Derek J. Bailey, Adam Jochem, et al. “A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.” Cell Metab 16, no. 5 (November 7, 2012): 672–83. https://doi.org/10.1016/j.cmet.2012.10.004.
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  - Volkening, Jeremy D., Derek J. Bailey, Christopher M. Rose, Paul A. Grimsrud, Maegen Howes-Podoll, Muthusubramanian Venkateshwaran, Michael S. Westphall, Jean-Michel Ané, Joshua J. Coon, and Michael R. Sussman. “A proteogenomic survey of the Medicago truncatula genome.” Mol Cell Proteomics 11, no. 10 (October 2012): 933–44. https://doi.org/10.1074/mcp.M112.019471.
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  - Rose, Christopher M., Muthusubramanian Venkateshwaran, Jeremy D. Volkening, Paul A. Grimsrud, Junko Maeda, Derek J. Bailey, Kwanghyun Park, et al. “Rapid phosphoproteomic and transcriptomic changes in the rhizobia-legume symbiosis.” Mol Cell Proteomics 11, no. 9 (September 2012): 724–44. https://doi.org/10.1074/mcp.M112.019208.
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  - Jayaraman, Dhileepkumar, Kari L. Forshey, Paul A. Grimsrud, and Jean-Michel Ané. “Leveraging proteomics to understand plant-microbe interactions.” Front Plant Sci 3 (2012): 44. https://doi.org/10.3389/fpls.2012.00044.
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  - Rose, Christopher M., Muthusubramanian Venkateshwaran, Paul A. Grimsrud, Michael S. Westphall, Michael R. Sussman, Joshua J. Coon, and Jean-Michel Ané. “Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data.” Front Plant Sci 3 (2012): 122. https://doi.org/10.3389/fpls.2012.00122.
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  - Hellberg, Kristina, Paul A. Grimsrud, Andrew C. Kruse, Leonard J. Banaszak, Douglas H. Ohlendorf, and David A. Bernlohr. “X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.” Protein Sci 19, no. 8 (August 2010): 1480–89. https://doi.org/10.1002/pro.427.
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  - Curtis, Jessica M., Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocio E. Foncea, David W. Graham, Jonathan R. Brestoff, et al. “Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.” Diabetes 59, no. 5 (May 2010): 1132–42. https://doi.org/10.2337/db09-1105.
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  - Grimsrud, Paul A., Danielle L. Swaney, Craig D. Wenger, Nicole A. Beauchene, and Joshua J. Coon. “Phosphoproteomics for the masses.” Acs Chem Biol 5, no. 1 (January 15, 2010): 105–19. https://doi.org/10.1021/cb900277e.
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  - Grimsrud, Paul A., Désirée den Os, Craig D. Wenger, Danielle L. Swaney, Daniel Schwartz, Michael R. Sussman, Jean-Michel Ané, and Joshua J. Coon. “Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes.” Plant Physiol 152, no. 1 (January 2010): 19–28. https://doi.org/10.1104/pp.109.149625.
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  - Grimsrud, Paul A., Hongwei Xie, Timothy J. Griffin, and David A. Bernlohr. “Oxidative stress and covalent modification of protein with bioactive aldehydes.” J Biol Chem 283, no. 32 (August 8, 2008): 21837–41. https://doi.org/10.1074/jbc.R700019200.
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  - Grimsrud, Paul A., Matthew J. Picklo, Timothy J. Griffin, and David A. Bernlohr. “Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.” Mol Cell Proteomics 6, no. 4 (April 2007): 624–37. https://doi.org/10.1074/mcp.M600120-MCP200.
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  - Pearson, Arwen R., Teresa De La Mora-Rey, M Elizabeth Graichen, Yongting Wang, Limei H. Jones, Sudha Marimanikkupam, Sean A. Agger, Paul A. Grimsrud, Victor L. Davidson, and Carrie M. Wilmot. “Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation.” Biochemistry 43, no. 18 (May 11, 2004): 5494–5502. https://doi.org/10.1021/bi049863l.
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Teaching & Mentoring
Advising & Mentoring
- Scott Lyons, Ph.D., Postdoctoral Research Associate October, 2020-present
  Mihaela Mocanu, Research Analyst I May, 2022-present
  James Draper, Data Technician II August 2016-present
Scholarly, Clinical, & Service Activities
Presentations & Appearances

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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Awards & Honors

Subject Headings

Selected Grants

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Advising & Mentoring

Presentations & Appearances