Overview
Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.
Current Appointments & Affiliations
Assistant Professor in Medicine
·
2021 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Duke Molecular Physiology Institute
·
2020 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Cysteine S-acetylation is a post-translational modification involved in metabolic regulation.
Preprint · May 21, 2024 Full text Link to item CitePyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.
Journal Article Cell Metab · June 6, 2023 Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of mitochondrial lipid stress attributable to one or more metabolic bottlenecks in the β-oxidation pathw ... Full text Link to item CiteHGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Journal Article JCI Insight · January 10, 2023 Carbohydrate response element-binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus associat ... Full text Link to item CiteRecent Grants
Mechanisms of lipid-induced bioenergetic stress in muscle
ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2028Stalling cancer at the ribosome
ResearchCollaborator · Awarded by V Foundation for Cancer Research · 2025 - 2028Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027View All Grants
Education, Training & Certifications
University of Minnesota, Twin Cities ·
2008
Ph.D.