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Paul Grimsrud

Assistant Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
104775, Durham, NC 27701
300 N Duke Street, 48-208K, Durham, NC 27701


Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.

Current Appointments & Affiliations

Assistant Professor in Medicine · 2021 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of Duke Molecular Physiology Institute · 2020 - Present Duke Molecular Physiology Institute, Duke Molecular Physiology Institute

Education, Training & Certifications

University of Minnesota, Twin Cities · 2008 Ph.D.