Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Minnesota, Twin Cities 2008
• 

  Leadership & Clinical Positions at Duke

  • Proteomics Section Leader, Duke Molecular Physiology Institute
• Recognition
• 

  In the News

  • JUL 30, 2018

    Duke Molecular Physiology Institute

    PAUL GRIMSRUD RECEIVES AHA AWARD
• 

  Awards & Honors

  • Integrating Research Ethics and Scholarship (IRES) Fellowship. The University of Wisconsin-Madison. 2012
  • Rozica and Sifra Yussim Award for Outstanding Basic Scientific Research in the Field of Diabetes Mellitus. University of Minnesota Medical Foundation. 2007
  • Outstanding Performance Award for Teaching Assistants. University of Minnesota, College of Biological Sciences . 2006
  • Ross A. Gortner Award for Research in Protein Chemistry. University of Minnesota, College of Biological Sciences. 2006
  • American Institute of Chemists Foundation Student Award for Ability, Leadership, and Professional Promise. St. Olaf College, Department of Chemistry. 2002
  • Phi Lambda Upsilon Honorary Chemical Society. St. Olaf College, Department of Chemistry. 2002
• Expertise
• 

  Subject Headings

  • Metabolism
  • Proteomics
• Research
• 

  Selected Grants

  • Mechanisms of lipid-induced bioenergetic stress in muscle awarded by National Institutes of Health 2010 - 2023
  • Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism awarded by National Institutes of Health 2018 - 2022
  • AHA Career Development Award awarded by  American Heart Association 2018 - 2021
  • Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2017 - 2021
  • Mitochondrial Protein Acetylation and Energy Metabolism in Muscle awarded by National Institutes of Health 2015 - 2018
  • Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2017
  • Novel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of Aging awarded by National Institutes of Health 2016 - 2017
  • Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by Sanford-Burnham Medical Research Institute 2017
• 

  Fellowships, Supported Research, & Other Grants

  • AHA Career Development Award (18CDA34110216) awarded by American Heart Association (AHA) 2018 - 2021
  • Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship (1F32DK091049-01A1) awarded by National Institutes of Health/ National Institute of Diabetes and Digestive and Kidney Diseases 2011 - 2014
  • Institutional National Research Service Award (2T32HL007741-11) awarded by National Institutes of Health/National Heart, Lung, and Blood Institute 2004 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Mills, Christine A., Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, and Michael J. Emanuele. “Sirtuin 5 is Regulated by the SCF-Cyclin F Ubiquitin Ligase and is Involved in Cell Cycle Control.” Mol Cell Biol, November 9, 2020. https://doi.org/10.1128/MCB.00269-20.
       Full Text  Link to Item
    • Davidson, Michael T., Paul A. Grimsrud, Ling Lai, James A. Draper, Kelsey H. Fisher-Wellman, Tara M. Narowski, Dennis M. Abraham, Timothy R. Koves, Daniel P. Kelly, and Deborah M. Muoio. “Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.” Circ Res 127, no. 8 (September 25, 2020): 1094–1108. https://doi.org/10.1161/CIRCRESAHA.120.317293.
       Full Text  Link to Item
    • Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.
       Full Text  Link to Item
    • Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.
       Full Text  Link to Item
    • Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.
       Full Text  Link to Item
    • Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.
       Full Text  Link to Item
    • White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.
       Full Text  Link to Item
    • Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.
       Full Text  Link to Item
    • Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.
       Full Text  Link to Item
    • Wagner, Gregory R., Dhaval P. Bhatt, Thomas M. O’Connell, J Will Thompson, Laura G. Dubois, Donald S. Backos, Hao Yang, et al. “A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.” Cell Metab 25, no. 4 (April 4, 2017): 823-837.e8. https://doi.org/10.1016/j.cmet.2017.03.006.
       Full Text  Link to Item
    • McDonnell, Eoin, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, and Matthew D. Hirschey. “Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.” Cell Rep 17, no. 6 (November 1, 2016): 1463–72. https://doi.org/10.1016/j.celrep.2016.10.012.
       Full Text  Link to Item
    • Davies, Michael N., Lilja Kjalarsdottir, J Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, and Deborah M. Muoio. “The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.” Cell Rep 14, no. 2 (January 12, 2016): 243–54. https://doi.org/10.1016/j.celrep.2015.12.030.
       Full Text  Link to Item
    • Dingley, Stephen D., Erzsebet Polyak, Julian Ostrovsky, Satish Srinivasan, Icksoo Lee, Amy B. Rosenfeld, Mai Tsukikawa, et al. “Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.” J Mol Biol 426, no. 11 (May 29, 2014): 2199–2216. https://doi.org/10.1016/j.jmb.2014.02.009.
       Full Text  Link to Item
    • Still, Amelia J., Brendan J. Floyd, Alexander S. Hebert, Craig A. Bingman, Joshua J. Carson, Drew R. Gunderson, Brendan K. Dolan, et al. “Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.” J Biol Chem 288, no. 36 (September 6, 2013): 26209–19. https://doi.org/10.1074/jbc.M113.483396.
       Full Text  Link to Item
    • Grimsrud, Paul A., Joshua J. Carson, Alex S. Hebert, Shane L. Hubler, Natalie M. Niemi, Derek J. Bailey, Adam Jochem, et al. “A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.” Cell Metab 16, no. 5 (November 7, 2012): 672–83. https://doi.org/10.1016/j.cmet.2012.10.004.
       Full Text  Link to Item
    • Volkening, Jeremy D., Derek J. Bailey, Christopher M. Rose, Paul A. Grimsrud, Maegen Howes-Podoll, Muthusubramanian Venkateshwaran, Michael S. Westphall, Jean-Michel Ané, Joshua J. Coon, and Michael R. Sussman. “A proteogenomic survey of the Medicago truncatula genome.” Mol Cell Proteomics 11, no. 10 (October 2012): 933–44. https://doi.org/10.1074/mcp.M112.019471.
       Full Text  Link to Item
    • Rose, Christopher M., Muthusubramanian Venkateshwaran, Jeremy D. Volkening, Paul A. Grimsrud, Junko Maeda, Derek J. Bailey, Kwanghyun Park, et al. “Rapid phosphoproteomic and transcriptomic changes in the rhizobia-legume symbiosis.” Mol Cell Proteomics 11, no. 9 (September 2012): 724–44. https://doi.org/10.1074/mcp.M112.019208.
       Full Text  Link to Item
    • Jayaraman, Dhileepkumar, Kari L. Forshey, Paul A. Grimsrud, and Jean-Michel Ané. “Leveraging proteomics to understand plant-microbe interactions.” Front Plant Sci 3 (2012): 44. https://doi.org/10.3389/fpls.2012.00044.
       Full Text  Link to Item
    • Rose, Christopher M., Muthusubramanian Venkateshwaran, Paul A. Grimsrud, Michael S. Westphall, Michael R. Sussman, Joshua J. Coon, and Jean-Michel Ané. “Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data.” Front Plant Sci 3 (2012): 122. https://doi.org/10.3389/fpls.2012.00122.
       Full Text  Link to Item
    • Hellberg, Kristina, Paul A. Grimsrud, Andrew C. Kruse, Leonard J. Banaszak, Douglas H. Ohlendorf, and David A. Bernlohr. “X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.” Protein Sci 19, no. 8 (August 2010): 1480–89. https://doi.org/10.1002/pro.427.
       Full Text  Link to Item
    • Curtis, Jessica M., Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocio E. Foncea, David W. Graham, Jonathan R. Brestoff, et al. “Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.” Diabetes 59, no. 5 (May 2010): 1132–42. https://doi.org/10.2337/db09-1105.
       Full Text  Link to Item
    • Grimsrud, Paul A., Danielle L. Swaney, Craig D. Wenger, Nicole A. Beauchene, and Joshua J. Coon. “Phosphoproteomics for the masses.” Acs Chem Biol 5, no. 1 (January 15, 2010): 105–19. https://doi.org/10.1021/cb900277e.
       Full Text  Link to Item
    • Grimsrud, Paul A., Désirée den Os, Craig D. Wenger, Danielle L. Swaney, Daniel Schwartz, Michael R. Sussman, Jean-Michel Ané, and Joshua J. Coon. “Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes.” Plant Physiol 152, no. 1 (January 2010): 19–28. https://doi.org/10.1104/pp.109.149625.
       Full Text  Link to Item
    • Grimsrud, Paul A., Hongwei Xie, Timothy J. Griffin, and David A. Bernlohr. “Oxidative stress and covalent modification of protein with bioactive aldehydes.” J Biol Chem 283, no. 32 (August 8, 2008): 21837–41. https://doi.org/10.1074/jbc.R700019200.
       Full Text  Link to Item
    • Grimsrud, Paul A., Matthew J. Picklo, Timothy J. Griffin, and David A. Bernlohr. “Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.” Mol Cell Proteomics 6, no. 4 (April 2007): 624–37. https://doi.org/10.1074/mcp.M600120-MCP200.
       Full Text  Link to Item
    • Pearson, Arwen R., Teresa De La Mora-Rey, M Elizabeth Graichen, Yongting Wang, Limei H. Jones, Sudha Marimanikkupam, Sean A. Agger, Paul A. Grimsrud, Victor L. Davidson, and Carrie M. Wilmot. “Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation.” Biochemistry 43, no. 18 (May 11, 2004): 5494–5502. https://doi.org/10.1021/bi049863l.
       Full Text  Link to Item
• Teaching & Mentoring
• 

  Advising & Mentoring

  • Scott Lyons, Ph.D., Postdoctoral Research Associate      October, 2020-present
    James Draper, Data Technician II                                 August 2016-present
• Scholarly, Clinical, & Service Activities
• 

  Presentations & Appearances

  • Integration of Lysine Modification Changes and Bioenergetic Phenotypes in Mouse Models of Cardiac Mitochondrial Protein Hyperacylation. 67TH ASMS Conference on Mass Spectrometry and Allied Topics . American Society for Mass Spectrometry (ASMS). June 2, 2019 - June 6, 2019  2019
  • Phosphoproteomics as a tool for uncovering novel mechanisms of metabolic regulation. Endocrinology Grand Rounds. Duke University School of Medicine. April 27, 2018  2018
  • Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. Omics Strategies to Study the Proteome. Keystone Symposia. January 29, 2017 - February 2, 2017  2017
  • Innovative technology for the large-scale study of proteins and their post-translational modifications (Invited). 11th Annual Land O’Lakes Bioanalytical Conference: A New Decade of Bioanalysis of Large and Small Molecules. University of Wisconsin School of Pharmacy. July 19, 2010 - July 23, 2010  2010
  • Deciphering Nod Factor Signal Transduction in Medicago truncatula Using Quantitative Phosphoproteomics (Invited). 27th Annual IPG Symposium: Plant Protein Phosphorylation. Interdisciplinary Plant Group (IPG), University of Missouri-Columbia . May 26, 2010  2010
  • Phosphoproteomic analysis of Medicago truncatula roots by tandem mass spectrometry utilizing both collision and electron-based fragmentation methods. 2009 Medicago Truncatula Model Legume Congress (Invited). Clemson University. July 12, 2009 - July 16, 2009  2009
  • Why Large-Scale Phosphoproteomic Analyses Benefit from the Joint Use of Collision and Electron-Based Fragmentation Methods. 57th ASMS Conference on Mass Spectrometry and Allied Topics. American Society for Mass Spectrometry (ASMS). May 31, 2009 - June 4, 2009  2009
  • Proteomic Analysis of HNE-Modified Proteins in Adipose Tissue (Invited). American Chemical Society 36th Annual Great Lakes Regional Meeting. American Chemical Society (ACS). October 17, 2004 - October 20, 2004  2004
• 

  Outreach & Engaged Scholarship

  • Event Organizer and Host. Intellectual Property in Academic Research Panel Discussion and Reception. University of Wisconsin-Madison, Department of Biochemistry. April 11, 2013  2013
  • Instructor and Teaching Coordinator. Technology Education in Science Summer Workshop. University of Wisconsin-Madison. 2009 - 2010  2009 - 2010
  • Chair of "Applications" Session. The 6th Annual Uppsala Conference on Electron Capture and Transfer Dissociation. University of Wisconsin-Madison. December 7, 2008 - December 10, 2008  2008

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.