Stem Cell and Gene Therapy for Cardiovascular Disease
Role of Paracrine Mechanisms
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Hodgkinson, CP; Gomez, JA; Bareja, A; Dzau, VJ
January 1, 2015
Many studies have demonstrated that the exogenous delivery of stem cells into injured myocardium results in functional improvements. It was originally thought that the regenerative properties of these stem cells arose from engraftment into the myocardium and subsequent differentiation into cardiac cells. However, this process was found to occur very rarely; far too low to account for the functional benefits observed. In the past decade, a new paradigm has emerged, namely that stem cells exert their reparative and regenerative effects predominantly through the release of biologically active molecules acting in a paracrine fashion on resident cells.
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Hodgkinson, C. P., Gomez, J. A., Bareja, A., & Dzau, V. J. (2015). Role of Paracrine Mechanisms. In Stem Cell and Gene Therapy for Cardiovascular Disease (pp. 39–48). https://doi.org/10.1016/B978-0-12-801888-0.00004-7
Hodgkinson, C. P., J. A. Gomez, A. Bareja, and V. J. Dzau. “Role of Paracrine Mechanisms.” In Stem Cell and Gene Therapy for Cardiovascular Disease, 39–48, 2015. https://doi.org/10.1016/B978-0-12-801888-0.00004-7.
Hodgkinson CP, Gomez JA, Bareja A, Dzau VJ. Role of Paracrine Mechanisms. In: Stem Cell and Gene Therapy for Cardiovascular Disease. 2015. p. 39–48.
Hodgkinson, C. P., et al. “Role of Paracrine Mechanisms.” Stem Cell and Gene Therapy for Cardiovascular Disease, 2015, pp. 39–48. Scopus, doi:10.1016/B978-0-12-801888-0.00004-7.
Hodgkinson CP, Gomez JA, Bareja A, Dzau VJ. Role of Paracrine Mechanisms. Stem Cell and Gene Therapy for Cardiovascular Disease. 2015. p. 39–48.