N-Acetylcysteine in the Management of Acute Liver Failure From Sickle Cell Hepatic Crisis.

Journal Article

N-acetylcysteine (NAC) has been well studied in the treatment of acetaminophen-induced and select non-acetaminophen-induced liver failure. However, its role in the management of sickle cell hepatic crisis resulting in acute liver failure (ALF) is unknown. We describe and discuss the novel and beneficial use of NAC in a 25-year-old man with ALF due to sickle cell hepatic crisis. We further review ALF in sickle cell disease and NAC in the treatment of non-acetaminophen-induced liver failure. Our case highlights the promising role of NAC in sickle cell-related liver injury.

Full Text

Duke Authors

Cited Authors

  • Zhang, X; Burroughs, S; Farooq, A; Bashir, MR; Muir, AJ; Patel, YA

Published Date

  • August 2019

Published In

Volume / Issue

  • 6 / 8

Start / End Page

  • e00161 -

PubMed ID

  • 31737700

Pubmed Central ID

  • PMC6791608

International Standard Serial Number (ISSN)

  • 2326-3253

Digital Object Identifier (DOI)

  • 10.14309/crj.0000000000000161


  • eng

Conference Location

  • United States