Brain immunology and immunotherapy in brain tumours.

Journal Article (Journal Article;Review)

Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Nevertheless, the requirements for successful therapy remain effective delivery and target specificity, while the dramatic heterogeneity of malignant gliomas at the genetic and immunological levels remains a profound challenge.

Full Text

Duke Authors

Cited Authors

  • Sampson, JH; Gunn, MD; Fecci, PE; Ashley, DM

Published Date

  • January 2020

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 12 - 25

PubMed ID

  • 31806885

Pubmed Central ID

  • PMC7327710

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/s41568-019-0224-7


  • eng

Conference Location

  • England