Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians.

Published

Journal Article

BACKGROUND: Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. MATERIALS AND METHODS: We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archival samples from the University of Ibadan, Nigeria. RESULTS: Nigerian cases of CRC were MSI-high in 43% and MSI-high CRC had significantly lower histological heterogeneity than microsatellite-stable CRC (20% vs. 55% respectively, p=0.046). Presence of signet ring cell differentiation (10-50% of tumor) was significantly higher in younger patients with CRC (<50 years) (odds ratio(OR)=5.93, 95% confidence interval(CI)=1.17-29.95, p=0.038). Poor differentiation (34%), invasive growth (96%), and high prevalence of mucinous (10%) and signet ring cell adenocarcinomas (4%) were among distinct features of Nigerian patients with CRC. CONCLUSION: MSI-high CRC is more common in West Africa and more detailed molecular and genetic analysis is warranted as CRC incidence and mortality continue to increase in the Sub-Saharan Africa.

Full Text

Duke Authors

Cited Authors

  • Irabor, DO; Oluwasola, OA; Ogunbiyi, OJ; Ogun, OG; Okolo, CA; Melas, M; Gruber, SB; Shi, C; Raskin, L

Published Date

  • May 2017

Published In

Volume / Issue

  • 37 / 5

Start / End Page

  • 2649 - 2654

PubMed ID

  • 28476840

Pubmed Central ID

  • 28476840

Electronic International Standard Serial Number (EISSN)

  • 1791-7530

Digital Object Identifier (DOI)

  • 10.21873/anticanres.11612

Language

  • eng

Conference Location

  • Greece