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Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians.

Publication ,  Journal Article
Irabor, DO; Oluwasola, OA; Ogunbiyi, OJ; Ogun, OG; Okolo, CA; Melas, M; Gruber, SB; Shi, C; Raskin, L
Published in: Anticancer Res
May 2017

BACKGROUND: Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. MATERIALS AND METHODS: We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archival samples from the University of Ibadan, Nigeria. RESULTS: Nigerian cases of CRC were MSI-high in 43% and MSI-high CRC had significantly lower histological heterogeneity than microsatellite-stable CRC (20% vs. 55% respectively, p=0.046). Presence of signet ring cell differentiation (10-50% of tumor) was significantly higher in younger patients with CRC (<50 years) (odds ratio(OR)=5.93, 95% confidence interval(CI)=1.17-29.95, p=0.038). Poor differentiation (34%), invasive growth (96%), and high prevalence of mucinous (10%) and signet ring cell adenocarcinomas (4%) were among distinct features of Nigerian patients with CRC. CONCLUSION: MSI-high CRC is more common in West Africa and more detailed molecular and genetic analysis is warranted as CRC incidence and mortality continue to increase in the Sub-Saharan Africa.

Duke Scholars

Published In

Anticancer Res

DOI

EISSN

1791-7530

Publication Date

May 2017

Volume

37

Issue

5

Start / End Page

2649 / 2654

Location

Greece

Related Subject Headings

  • Young Adult
  • Prevalence
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Nigeria
  • Neoplasm Staging
  • Middle Aged
  • Microsatellite Instability
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Irabor, D. O., Oluwasola, O. A., Ogunbiyi, O. J., Ogun, O. G., Okolo, C. A., Melas, M., … Raskin, L. (2017). Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. Anticancer Res, 37(5), 2649–2654. https://doi.org/10.21873/anticanres.11612
Irabor, David O., Olayiwola A. Oluwasola, Olufemi J. Ogunbiyi, Olabiyi G. Ogun, Clement A. Okolo, Marilena Melas, Stephen B. Gruber, Chanjuan Shi, and Leon Raskin. “Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians.Anticancer Res 37, no. 5 (May 2017): 2649–54. https://doi.org/10.21873/anticanres.11612.
Irabor DO, Oluwasola OA, Ogunbiyi OJ, Ogun OG, Okolo CA, Melas M, et al. Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. Anticancer Res. 2017 May;37(5):2649–54.
Irabor, David O., et al. “Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians.Anticancer Res, vol. 37, no. 5, May 2017, pp. 2649–54. Pubmed, doi:10.21873/anticanres.11612.
Irabor DO, Oluwasola OA, Ogunbiyi OJ, Ogun OG, Okolo CA, Melas M, Gruber SB, Shi C, Raskin L. Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. Anticancer Res. 2017 May;37(5):2649–2654.

Published In

Anticancer Res

DOI

EISSN

1791-7530

Publication Date

May 2017

Volume

37

Issue

5

Start / End Page

2649 / 2654

Location

Greece

Related Subject Headings

  • Young Adult
  • Prevalence
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Nigeria
  • Neoplasm Staging
  • Middle Aged
  • Microsatellite Instability
  • Male
  • Humans