Connecting cytokines and cellular signals in the nephron during CKD and hypertension.

Journal Article (Journal Article)

Chronic kidney disease features chronic inflammation and fibrosis, both of which contribute to and are exacerbated by arterial hypertension. The contribution of immune responses to renal sodium retention has received intense scrutiny. In this regard, the article by Furusho et al. details a mechanism wherein intrarenal TNFα augments salt-sensitive hypertension during CKD via activation of the WNK1-SPAKNCC phosphorylation cascade.

Full Text

Duke Authors

Cited Authors

  • Wen, Y; Crowley, SD

Published Date

  • April 2020

Published In

Volume / Issue

  • 97 / 4

Start / End Page

  • 651 - 653

PubMed ID

  • 32200858

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2020.01.005


  • eng

Conference Location

  • United States