Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide.

Journal Article (Journal Article;Review)

Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.