Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide.
Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.
Khaw, SL; Downie, PA; Waters, KD; Ashley, DM; Heath, JA
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