Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide.

Journal Article (Journal Article;Review)

Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.

Full Text

Duke Authors

Cited Authors

  • Khaw, SL; Downie, PA; Waters, KD; Ashley, DM; Heath, JA

Published Date

  • September 2007

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • 341 - 343

PubMed ID

  • 16333822

International Standard Serial Number (ISSN)

  • 1545-5009

Digital Object Identifier (DOI)

  • 10.1002/pbc.20617


  • eng

Conference Location

  • United States