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Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses.

Publication ,  Journal Article
Dumm, RE; Wellford, SA; Moseman, EA; Heaton, NS
Published in: Cell Rep
September 1, 2020

Influenza viruses initiate infection in the upper respiratory tract (URT), but early viral tropism and the importance of cell-type-specific antiviral responses in this tissue remain incompletely understood. By infecting transgenic lox-stop-lox reporter mice with a Cre-recombinase-expressing influenza B virus, we identify olfactory sensory neurons (OSNs) as a major viral cell target in the URT. These cells become infected, then eliminate the virus and survive in the host post-resolution of infection. OSN responses to infection are characterized by a strong induction of interferon-stimulated genes and more rapid clearance of viral protein relative to other cells in the epithelium. We speculate that this cell-type-specific response likely serves to protect the central nervous system from infection. More broadly, these results highlight the importance of evaluating antiviral responses across different cell types, even those within the same tissue, to more fully understand the mechanisms of viral disease.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

September 1, 2020

Volume

32

Issue

9

Start / End Page

108103

Location

United States

Related Subject Headings

  • Virus Replication
  • Respiratory Tract Infections
  • Mice
  • Influenza, Human
  • Influenza A virus
  • Humans
  • Animals
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology
 

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Dumm, R. E., Wellford, S. A., Moseman, E. A., & Heaton, N. S. (2020). Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses. Cell Rep, 32(9), 108103. https://doi.org/10.1016/j.celrep.2020.108103
Dumm, Rebekah E., Sebastian A. Wellford, E Ashley Moseman, and Nicholas S. Heaton. “Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses.Cell Rep 32, no. 9 (September 1, 2020): 108103. https://doi.org/10.1016/j.celrep.2020.108103.
Dumm, Rebekah E., et al. “Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses.Cell Rep, vol. 32, no. 9, Sept. 2020, p. 108103. Pubmed, doi:10.1016/j.celrep.2020.108103.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

September 1, 2020

Volume

32

Issue

9

Start / End Page

108103

Location

United States

Related Subject Headings

  • Virus Replication
  • Respiratory Tract Infections
  • Mice
  • Influenza, Human
  • Influenza A virus
  • Humans
  • Animals
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology