Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.

Journal Article (Journal Article)

Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic variants underlying the short sleep trait, we found two different mutations in the same gene (metabotropic glutamate receptor 1) from two independent natural short sleep families. In vitro, both of the mutations exhibited loss of function in receptor-mediated signaling. In vivo, the mice carrying the individual mutations both demonstrated short sleep behavior. In brain slices, both of the mutations changed the electrical properties and increased excitatory synaptic transmission. These results highlight the important role of metabotropic glutamate receptor 1 in modulating sleep duration.

Full Text

Duke Authors

Cited Authors

  • Shi, G; Yin, C; Fan, Z; Xing, L; Mostovoy, Y; Kwok, P-Y; Ashbrook, LH; Krystal, AD; Ptáček, LJ; Fu, Y-H

Published Date

  • January 11, 2021

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 13 - 24.e4

PubMed ID

  • 33065013

Electronic International Standard Serial Number (EISSN)

  • 1879-0445

Digital Object Identifier (DOI)

  • 10.1016/j.cub.2020.09.071


  • eng

Conference Location

  • England