Technology of deep brain stimulation: current status and future directions.

Journal Article (Review;Journal Article)

Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and dystonia, and is also under active investigation for other conditions linked to pathological circuitry, including major depressive disorder and Alzheimer disease. Modern DBS systems, borrowed from the cardiac field, consist of an intracranial electrode, an extension wire and a pulse generator, and have evolved slowly over the past two decades. Advances in engineering and imaging along with an improved understanding of brain disorders are poised to reshape how DBS is viewed and delivered to patients. Breakthroughs in electrode and battery designs, stimulation paradigms, closed-loop and on-demand stimulation, and sensing technologies are expected to enhance the efficacy and tolerability of DBS. In this Review, we provide a comprehensive overview of the technical development of DBS, from its origins to its future. Understanding the evolution of DBS technology helps put the currently available systems in perspective and allows us to predict the next major technological advances and hurdles in the field.

Full Text

Duke Authors

Cited Authors

  • Krauss, JK; Lipsman, N; Aziz, T; Boutet, A; Brown, P; Chang, JW; Davidson, B; Grill, WM; Hariz, MI; Horn, A; Schulder, M; Mammis, A; Tass, PA; Volkmann, J; Lozano, AM

Published Date

  • February 2021

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 75 - 87

PubMed ID

  • 33244188

Pubmed Central ID

  • PMC7116699

Electronic International Standard Serial Number (EISSN)

  • 1759-4766

International Standard Serial Number (ISSN)

  • 1759-4758

Digital Object Identifier (DOI)

  • 10.1038/s41582-020-00426-z


  • eng