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Technology of deep brain stimulation: current status and future directions.

Publication ,  Journal Article
Krauss, JK; Lipsman, N; Aziz, T; Boutet, A; Brown, P; Chang, JW; Davidson, B; Grill, WM; Hariz, MI; Horn, A; Schulder, M; Mammis, A; Tass, PA ...
Published in: Nature reviews. Neurology
February 2021

Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and dystonia, and is also under active investigation for other conditions linked to pathological circuitry, including major depressive disorder and Alzheimer disease. Modern DBS systems, borrowed from the cardiac field, consist of an intracranial electrode, an extension wire and a pulse generator, and have evolved slowly over the past two decades. Advances in engineering and imaging along with an improved understanding of brain disorders are poised to reshape how DBS is viewed and delivered to patients. Breakthroughs in electrode and battery designs, stimulation paradigms, closed-loop and on-demand stimulation, and sensing technologies are expected to enhance the efficacy and tolerability of DBS. In this Review, we provide a comprehensive overview of the technical development of DBS, from its origins to its future. Understanding the evolution of DBS technology helps put the currently available systems in perspective and allows us to predict the next major technological advances and hurdles in the field.

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Published In

Nature reviews. Neurology

DOI

EISSN

1759-4766

ISSN

1759-4758

Publication Date

February 2021

Volume

17

Issue

2

Start / End Page

75 / 87

Related Subject Headings

  • Parkinson Disease
  • Implantable Neurostimulators
  • Humans
  • Forecasting
  • Essential Tremor
  • Dystonic Disorders
  • Depressive Disorder, Major
  • Deep Brain Stimulation
  • Biomedical Technology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krauss, J. K., Lipsman, N., Aziz, T., Boutet, A., Brown, P., Chang, J. W., … Lozano, A. M. (2021). Technology of deep brain stimulation: current status and future directions. Nature Reviews. Neurology, 17(2), 75–87. https://doi.org/10.1038/s41582-020-00426-z
Krauss, Joachim K., Nir Lipsman, Tipu Aziz, Alexandre Boutet, Peter Brown, Jin Woo Chang, Benjamin Davidson, et al. “Technology of deep brain stimulation: current status and future directions.Nature Reviews. Neurology 17, no. 2 (February 2021): 75–87. https://doi.org/10.1038/s41582-020-00426-z.
Krauss JK, Lipsman N, Aziz T, Boutet A, Brown P, Chang JW, et al. Technology of deep brain stimulation: current status and future directions. Nature reviews Neurology. 2021 Feb;17(2):75–87.
Krauss, Joachim K., et al. “Technology of deep brain stimulation: current status and future directions.Nature Reviews. Neurology, vol. 17, no. 2, Feb. 2021, pp. 75–87. Epmc, doi:10.1038/s41582-020-00426-z.
Krauss JK, Lipsman N, Aziz T, Boutet A, Brown P, Chang JW, Davidson B, Grill WM, Hariz MI, Horn A, Schulder M, Mammis A, Tass PA, Volkmann J, Lozano AM. Technology of deep brain stimulation: current status and future directions. Nature reviews Neurology. 2021 Feb;17(2):75–87.

Published In

Nature reviews. Neurology

DOI

EISSN

1759-4766

ISSN

1759-4758

Publication Date

February 2021

Volume

17

Issue

2

Start / End Page

75 / 87

Related Subject Headings

  • Parkinson Disease
  • Implantable Neurostimulators
  • Humans
  • Forecasting
  • Essential Tremor
  • Dystonic Disorders
  • Depressive Disorder, Major
  • Deep Brain Stimulation
  • Biomedical Technology