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Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do?

Publication ,  Journal Article
Kappus, MR; Wolfe, CR; Muir, AJ
Published in: J Infect Dis
November 27, 2020

The opioid epidemic has resulted in an increase in organ donors with hepatitis C virus (HCV) infection in the United States. With the development of direct-acting antiviral regimens that offer high sustained virologic response rates even in the setting of immunosuppression after transplantation, these HCV-viremic organs are now being offered to transplant candidates with or without preexisting HCV infection. Strategies for HCV treatment with HCV-viremic organs have included delayed and preemptive approaches. This review will discuss key studies in the different solid organ transplants, recent reports of adverse events, and ethical and regulatory considerations. The efficacy of current HCV therapies has created this important opportunity to improve survival for patients with end-organ failure through greater access to organ transplantation and decreased waitlist mortality rate.

Duke Scholars

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

November 27, 2020

Volume

222

Issue

Suppl 9

Start / End Page

S794 / S801

Location

United States

Related Subject Headings

  • United States
  • Tissue Donors
  • Organ Transplantation
  • Microbiology
  • Immunocompromised Host
  • Humans
  • Hepatitis C
  • Donor Selection
  • Clinical Trials as Topic
  • Antiviral Agents
 

Citation

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Kappus, M. R., Wolfe, C. R., & Muir, A. J. (2020). Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do? J Infect Dis, 222(Suppl 9), S794–S801. https://doi.org/10.1093/infdis/jiaa420
Kappus, Matthew R., Cameron R. Wolfe, and Andrew J. Muir. “Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do?J Infect Dis 222, no. Suppl 9 (November 27, 2020): S794–801. https://doi.org/10.1093/infdis/jiaa420.
Kappus MR, Wolfe CR, Muir AJ. Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do? J Infect Dis. 2020 Nov 27;222(Suppl 9):S794–801.
Kappus, Matthew R., et al. “Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do?J Infect Dis, vol. 222, no. Suppl 9, Nov. 2020, pp. S794–801. Pubmed, doi:10.1093/infdis/jiaa420.
Kappus MR, Wolfe CR, Muir AJ. Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do? J Infect Dis. 2020 Nov 27;222(Suppl 9):S794–S801.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

November 27, 2020

Volume

222

Issue

Suppl 9

Start / End Page

S794 / S801

Location

United States

Related Subject Headings

  • United States
  • Tissue Donors
  • Organ Transplantation
  • Microbiology
  • Immunocompromised Host
  • Humans
  • Hepatitis C
  • Donor Selection
  • Clinical Trials as Topic
  • Antiviral Agents