Pathophysiology of Hypertension: The Mosaic Theory and Beyond.

Journal Article (Journal Article;Review)

Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage. Over the years, Dr Page modified his paradigm, and new concepts regarding oxidative stress, inflammation, genetics, sodium homeostasis, and the microbiome have arisen that allow further refinements of the Mosaic Theory. A constant feature of this approach to understanding hypertension is that the various nodes are interdependent and that these almost certainly vary between experimental models and between individuals with hypertension. This review discusses these new concepts and provides an introduction to other reviews in this compendium of Circulation Research.

Full Text

Duke Authors

Cited Authors

  • Harrison, DG; Coffman, TM; Wilcox, CS

Published Date

  • April 2, 2021

Published In

Volume / Issue

  • 128 / 7

Start / End Page

  • 847 - 863

PubMed ID

  • 33793328

Pubmed Central ID

  • PMC8023760

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.121.318082


  • eng

Conference Location

  • United States