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Pathophysiology of Hypertension: The Mosaic Theory and Beyond.

Publication ,  Journal Article
Harrison, DG; Coffman, TM; Wilcox, CS
Published in: Circ Res
April 2, 2021

Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage. Over the years, Dr Page modified his paradigm, and new concepts regarding oxidative stress, inflammation, genetics, sodium homeostasis, and the microbiome have arisen that allow further refinements of the Mosaic Theory. A constant feature of this approach to understanding hypertension is that the various nodes are interdependent and that these almost certainly vary between experimental models and between individuals with hypertension. This review discusses these new concepts and provides an introduction to other reviews in this compendium of Circulation Research.

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Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

April 2, 2021

Volume

128

Issue

7

Start / End Page

847 / 863

Location

United States

Related Subject Headings

  • Vasoconstrictor Agents
  • Sodium Chloride
  • Risk Factors
  • Reactive Oxygen Species
  • Microbiota
  • Kidney
  • Inflammation
  • Hypertension
  • Humans
  • Central Nervous System
 

Citation

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Harrison, D. G., Coffman, T. M., & Wilcox, C. S. (2021). Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Circ Res, 128(7), 847–863. https://doi.org/10.1161/CIRCRESAHA.121.318082
Harrison, David G., Thomas M. Coffman, and Christopher S. Wilcox. “Pathophysiology of Hypertension: The Mosaic Theory and Beyond.Circ Res 128, no. 7 (April 2, 2021): 847–63. https://doi.org/10.1161/CIRCRESAHA.121.318082.
Harrison DG, Coffman TM, Wilcox CS. Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Circ Res. 2021 Apr 2;128(7):847–63.
Harrison, David G., et al. “Pathophysiology of Hypertension: The Mosaic Theory and Beyond.Circ Res, vol. 128, no. 7, Apr. 2021, pp. 847–63. Pubmed, doi:10.1161/CIRCRESAHA.121.318082.
Harrison DG, Coffman TM, Wilcox CS. Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Circ Res. 2021 Apr 2;128(7):847–863.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

April 2, 2021

Volume

128

Issue

7

Start / End Page

847 / 863

Location

United States

Related Subject Headings

  • Vasoconstrictor Agents
  • Sodium Chloride
  • Risk Factors
  • Reactive Oxygen Species
  • Microbiota
  • Kidney
  • Inflammation
  • Hypertension
  • Humans
  • Central Nervous System