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Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.

Publication ,  Journal Article
Krishnamoorthy, V; Manley, GT; Jain, S; Sun, S; Foreman, B; Komisarow, J; Laskowitz, DT; Mathew, JP; Hernandez, A; James, ML; Vavilala, MS ...
Published in: J Neurosurg Anesthesiol
April 1, 2022

BACKGROUND: Traumatic brain injury (TBI) is a major global health problem. Little research has addressed extracranial organ dysfunction following TBI, particularly myocardial injury. Using a sensitive marker of myocardial injury-high sensitivity troponin (hsTn)-we examined the incidence of early myocardial injury following TBI and explored its association with neurological outcomes following moderate-severe TBI. METHODS: We conducted a pilot cohort study of 133 adult (age above 17 y) subjects enrolled in the TRACK-TBI 18-center prospective cohort study. Descriptive statistics were used to examine the incidence of myocardial injury (defined as hsTn >99th percentile for a standardized reference population) across TBI severities, and to explore the association of myocardial injury with a 6-month extended Glasgow Outcome Score among patients with moderate-severe TBI. RESULTS: The mean (SD) age of the participants was 44 (17) years, and 87 (65%) were male. Twenty-six patients (20%) developed myocardial injury following TBI; myocardial injury was present in 15% of mild TBI patients and 29% of moderate-severe TBI patients (P=0.13). Median (interquartile range) hsTn values were 3.8 ng/L (2.1, 9.0), 5.8 ng/L (4.5, 34.6), and 10.2 ng/L (3.0, 34.0) in mild, moderate, and severe TBI participants, respectively (P=0.04). Overall, 11% of participants with moderate-severe TBI and myocardial injury experienced a good outcome (6-mo extended Glasgow Outcome Score≥5) at 6 months, compared with 65% in the group that did not experience myocardial injury (P=0.01). CONCLUSIONS: Myocardial injury is common following TBI, with a likely dose-response relationship with TBI severity. Early myocardial injury was associated with poor 6-month clinical outcomes following moderate-severe TBI.

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Published In

J Neurosurg Anesthesiol

DOI

EISSN

1537-1921

Publication Date

April 1, 2022

Volume

34

Issue

2

Start / End Page

233 / 237

Location

United States

Related Subject Headings

  • Prospective Studies
  • Pilot Projects
  • Male
  • Incidence
  • Humans
  • Glasgow Coma Scale
  • Cohort Studies
  • Brain Injuries, Traumatic
  • Anesthesiology
  • Adult
 

Citation

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Chicago
ICMJE
MLA
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Krishnamoorthy, V., Manley, G. T., Jain, S., Sun, S., Foreman, B., Komisarow, J., … TRACK-TBI Investigators, . (2022). Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study. J Neurosurg Anesthesiol, 34(2), 233–237. https://doi.org/10.1097/ANA.0000000000000772
Krishnamoorthy, Vijay, Geoffrey T. Manley, Sonia Jain, Shelly Sun, Brandon Foreman, Jordan Komisarow, Daniel T. Laskowitz, et al. “Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.J Neurosurg Anesthesiol 34, no. 2 (April 1, 2022): 233–37. https://doi.org/10.1097/ANA.0000000000000772.
Krishnamoorthy V, Manley GT, Jain S, Sun S, Foreman B, Komisarow J, et al. Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study. J Neurosurg Anesthesiol. 2022 Apr 1;34(2):233–7.
Krishnamoorthy, Vijay, et al. “Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.J Neurosurg Anesthesiol, vol. 34, no. 2, Apr. 2022, pp. 233–37. Pubmed, doi:10.1097/ANA.0000000000000772.
Krishnamoorthy V, Manley GT, Jain S, Sun S, Foreman B, Komisarow J, Laskowitz DT, Mathew JP, Hernandez A, James ML, Vavilala MS, Markowitz AJ, Korley FK, TRACK-TBI Investigators. Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study. J Neurosurg Anesthesiol. 2022 Apr 1;34(2):233–237.

Published In

J Neurosurg Anesthesiol

DOI

EISSN

1537-1921

Publication Date

April 1, 2022

Volume

34

Issue

2

Start / End Page

233 / 237

Location

United States

Related Subject Headings

  • Prospective Studies
  • Pilot Projects
  • Male
  • Incidence
  • Humans
  • Glasgow Coma Scale
  • Cohort Studies
  • Brain Injuries, Traumatic
  • Anesthesiology
  • Adult