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Joseph P. Mathew

Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Anesthesiology, Cardiothoracic
Box 3094 Med Ctr, Durham, NC 27710
2301 Erwin Road, 5692 Hafs Building, Durham, NC 27710

Overview


Current research interests include:
1. The relationship between white matter patency, functional connectivity (fMRI) and neurocognitive function following cardiac surgery.
2. The relationship between global and regional cortical beta-amyloid deposition and postoperative cognitive decline.
3. The effect of lidocaine infusion upon neurocognitive function following cardiac surgery.
4. The association between genotype and outcome after cardiac surgery.
5. Atrial fibrillation following cardiopulmonary bypass.

Current Appointments & Affiliations


Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology · 2011 - Present Anesthesiology, Cardiothoracic, Anesthesiology
Professor of Anesthesiology · 2007 - Present Anesthesiology, Cardiothoracic, Anesthesiology
Chair of Anesthesiology · 2015 - Present Anesthesiology, Clinical Science Departments
Core Faculty in Innovation & Entrepreneurship · 2018 - Present Duke Innovation & Entrepreneurship, University Initiatives & Academic Support Units

Recent Publications


Neurocognitive Dysfunction After Short (<20 Minutes) Duration Hypothermic Circulatory Arrest.

Journal Article Ann Thorac Surg · February 2025 BACKGROUND: It has long been held that the safe duration of hypothermic circulatory arrest (HCA) is at least 25 to 30 minutes. However, this belief is based primarily on clinical outcomes research and has not been systematically investigated using more sen ... Full text Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal Article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Link to item Cite
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Recent Grants


Integrated Training in Anesthesiology Research

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 2026

Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)

Clinical TrialPrincipal Investigator · Awarded by National Institute on Aging · 2021 - 2026

The Role of the Aging Brain-Heart-Immune Axis in Postoperative Delirium

ResearchMentor · Awarded by National Institutes of Health · 2022 - 2025

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Education, Training & Certifications


University of Massachusetts, Amherst · 2013 M.B.A.
Duke University, School of Medicine · 2008 M.H.S.
University of Texas at Dallas · 1986 M.D.