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Joseph P. Mathew

Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Anesthesiology, Cardiothoracic
Box 3094 Med Ctr, Durham, NC 27710
2301 Erwin Road, 5692 Hafs Building, Durham, NC 27710

Overview


Current research interests include:
1. The relationship between white matter patency, functional connectivity (fMRI) and neurocognitive function following cardiac surgery.
2. The relationship between global and regional cortical beta-amyloid deposition and postoperative cognitive decline.
3. The effect of lidocaine infusion upon neurocognitive function following cardiac surgery.
4. The association between genotype and outcome after cardiac surgery.
5. Atrial fibrillation following cardiopulmonary bypass.

Current Appointments & Affiliations


Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology · 2011 - Present Anesthesiology, Cardiothoracic, Anesthesiology
Professor of Anesthesiology · 2007 - Present Anesthesiology, Cardiothoracic, Anesthesiology
Chair of Anesthesiology · 2015 - Present Anesthesiology, Clinical Science Departments
Core Faculty in Innovation & Entrepreneurship · 2018 - Present Duke Innovation & Entrepreneurship, University Initiatives & Academic Support Units

Recent Publications


Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies.

Journal Article Br J Anaesth · July 2025 BACKGROUND: We previously have shown that low intraoperative EEG alpha power is associated with impaired preoperative cognition, a delirium risk factor, and that intraoperative anaesthetic-dose-adjusted EEG bispectral index values were associated with a fo ... Full text Link to item Cite

General anesthesia-activated neurons in the central amygdala mediate antinociception: Distinct roles in acute versus chronic phases of nerve injury.

Journal Article Anesthesiology · May 7, 2025 BACKGROUND: General anesthesia (GA), such as isoflurane, induces analgesia (loss of pain) and loss of consciousness through mechanisms that are not fully understood. A distinct population of GABAergic neurons has been recently identified in the central amy ... Full text Link to item Cite
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Recent Grants


Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)

Clinical TrialPrincipal Investigator · Awarded by National Institute on Aging · 2021 - 2026

The Role of the Aging Brain-Heart-Immune Axis in Postoperative Delirium

ResearchMentor · Awarded by National Institutes of Health · 2022 - 2025

FAER GEMSSTAR Supplement (rolling deadline)

ResearchMentor · Awarded by Foundation for Anesthesia Education and Research · 2023 - 2025

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Education, Training & Certifications


University of Massachusetts, Amherst · 2013 M.B.A.
Duke University, School of Medicine · 2008 M.H.S.
University of Texas, Dallas · 1986 M.D.