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Joseph P. Mathew

Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Anesthesiology, Cardiothoracic
Box 3094 Med Ctr, Durham, NC 27710
2301 Erwin Road, 5692 HAFS Building, Durham, NC 27710

Overview


Current research interests include:
1. The relationship between white matter patency, functional connectivity (fMRI) and neurocognitive function following cardiac surgery.
2. The relationship between global and regional cortical beta-amyloid deposition and postoperative cognitive decline.
3. The effect of lidocaine infusion upon neurocognitive function following cardiac surgery.
4. The association between genotype and outcome after cardiac surgery.
5. Atrial fibrillation following cardiopulmonary bypass.

Current Duke Appointments & Affiliations


Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology · 2011 - Present Anesthesiology, Cardiothoracic, Anesthesiology
Professor of Anesthesiology · 2007 - Present Anesthesiology, Cardiothoracic, Anesthesiology

Recent Scholarly Works


Association of blood pressure variability with clinical and biomarker outcomes in moderate to severe TBI: A TRACK-TBI study.

Journal article J Clin Neurosci · July 2026 INTRODUCTION: Traumatic brain injury (TBI) represents a significant global health burden and often results in functional impairment. Blood pressure variability (BPV), a surrogate marker of autonomic dysfunction, has been shown to influence outcomes in pati ... Full text Link to item Cite

Association of Preoperative Posterior Cingulate Cortex Microstructural Damage With Postoperative Delirium.

Journal article Anesth Analg · June 17, 2026 BACKGROUND: Postoperative delirium is the most common postsurgical complication in older adults and is associated with an increased risk of long-term cognitive decline and Alzheimer's disease (AD) and related dementias (ADRD). However, the neurological bas ... Full text Open Access Link to item Cite

Association of Preinjury Beta-Blocker Exposure With Brain Injury Biomarkers Following Traumatic Brain Injury.

Journal article J Neurosurg Anesthesiol · April 1, 2026 OBJECTIVE: Beta-blockers have been studied for their impact on traumatic brain injury (TBI). We aimed to examine the association of preinjury beta-blocker exposure with early brain injury biomarker levels and outcomes following TBI. METHODS: We retrospecti ... Full text Open Access Link to item Cite
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Recent Grants


Integrated Training in Anesthesiology Research

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2031

Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)

Clinical TrialPrincipal Investigator · Awarded by National Institute on Aging · 2021 - 2027

Embolic Protection in Patients Undergoing High Risk Valve Surgery

Clinical TrialPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2023 - 2026

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Education


University of Massachusetts, Amherst · 2013 M.B.A.
Duke University, School of Medicine · 2008 M.H.S.
University of Texas, Dallas · 1986 M.D.