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Joseph P. Mathew

Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Anesthesiology, Cardiothoracic
Box 3094 Med Ctr, Durham, NC 27710
2301 Erwin Road, 5692 HAFS Building, Durham, NC 27710

Overview


Current research interests include:
1. The relationship between white matter patency, functional connectivity (fMRI) and neurocognitive function following cardiac surgery.
2. The relationship between global and regional cortical beta-amyloid deposition and postoperative cognitive decline.
3. The effect of lidocaine infusion upon neurocognitive function following cardiac surgery.
4. The association between genotype and outcome after cardiac surgery.
5. Atrial fibrillation following cardiopulmonary bypass.

Current Appointments & Affiliations


Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology · 2011 - Present Anesthesiology, Cardiothoracic, Anesthesiology
Professor of Anesthesiology · 2007 - Present Anesthesiology, Cardiothoracic, Anesthesiology

Recent Publications


Mixed-methods Analysis of Preoperative Distress and Postoperative Outcomes in a Prospective, Observational Cohort of Older Adults.

Journal Article Anesthesiology · January 1, 2026 BACKGROUND: The effect of psychological distress on general geriatric surgery outcomes remains unexplored despite recommendations for routine, preoperative distress screening. This study aimed to assess preoperative distress measures in a general geriatric ... Full text Link to item Cite

Developing Topics.

Journal Article Alzheimers Dement · December 2025 BACKGROUND: Postoperative delirium (POD), characterized by acute fluctuations in consciousness and attention, is associated with increased risk of Alzheimer's disease and related dementias. However, the neural mechanisms underlying attention impairments in ... Full text Link to item Cite

Early beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study.

Journal Article J Intensive Care Soc · November 2025 BACKGROUND: Beta-blockers have been studied for potential benefits in traumatic brain injury (TBI). This study aimed to investigate the association between early beta-blocker exposure and brain injury biomarkers following moderate-severe TBI. METHODS: We c ... Full text Open Access Link to item Cite
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Recent Grants


Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)

Clinical TrialPrincipal Investigator · Awarded by National Institute on Aging · 2021 - 2026

Embolic Protection in Patients Undergoing High Risk Valve Surgery

Clinical TrialPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2023 - 2026

The Role of the Aging Brain-Heart-Immune Axis in Postoperative Delirium

ResearchMentor · Awarded by National Institutes of Health · 2022 - 2025

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Education, Training & Certifications


University of Massachusetts, Amherst · 2013 M.B.A.
Duke University, School of Medicine · 2008 M.H.S.
University of Texas, Dallas · 1986 M.D.