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Joseph P. Mathew

Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Anesthesiology, Cardiothoracic
Box 3094 Med Ctr, Durham, NC 27710
2301 Erwin Road, 5692 Hafs Building, Durham, NC 27710

Selected Grants


Integrated Training in Anesthesiology Research

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 2026

Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)

Clinical TrialPrincipal Investigator · Awarded by National Institute on Aging · 2021 - 2026

The Role of the Aging Brain-Heart-Immune Axis in Postoperative Delirium

ResearchMentor · Awarded by National Institutes of Health · 2022 - 2025

FAER GEMSSTAR Supplement (rolling deadline)

ResearchMentor · Awarded by Foundation for Anesthesia Education and Research · 2023 - 2025

Embolic Protection in Patients Undergoing High Risk Valve Surgery

Clinical TrialPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2023 - 2025

Identification and Validation of a Novel Central Analgesia Circuit

ResearchPrincipal Investigator · Awarded by Massachusetts Institute of Technology · 2021 - 2024

The Association of Blood-brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium

ResearchMentor · Awarded by Foundation for Anesthesia Education and Research · 2021 - 2024

The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium

ResearchMentor · Awarded by National Institutes of Health · 2021 - 2024

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2023

Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies

ResearchMentor · Awarded by National Institutes of Health · 2017 - 2023

Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium Agreement

ResearchPrincipal Investigator · Awarded by Mount Sinai School of Medicine · 2019 - 2023

A High-Performance 3T MRI for Brain Imaging

EquipmentMinor User · Awarded by National Institutes of Health · 2021 - 2022

Enhanced neutrophil SUMOylation as a key to anti-inflammatory effects of hypothermia

ResearchSignificant Contributor · Awarded by American Heart Association · 2019 - 2022

The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium

ResearchMentor · Awarded by Society for Neuroscience in Anesthesiology and Critical Care · 2020 - 2021

Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium Agreement

ResearchPrincipal Investigator · Awarded by Mount Sinai School of Medicine · 2013 - 2021

The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction

FellowshipPrincipal Investigator · Awarded by Foundation for Anesthesia Education and Research · 2019 - 2021

Platelets as regulators of inflammation and tissue injury after cardiac surgery

ResearchSignificant Contributor · Awarded by American Heart Association · 2015 - 2019

The Significance of Perioperative Changes in CSF tau levels in the Elderly

ResearchMentor · Awarded by National Institutes of Health · 2015 - 2018

Core Clinical Centers for the CTSN

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2018

AA Contract: Innovative Educational Programs

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Mednax, Inc. · 2015 - 2018

The trajectory and significance of perioperative changes in AD biomarkers

ResearchMentor · Awarded by International Anesthesia Research Society · 2014 - 2018

Platelet/Mast cell Interactions as Determinants of End-Organ Injury in Cardiac Surgery

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2015 - 2017

Lidocaine for Neuroprotection During Cardiac Surgery

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2016

Functional connectivity changes in attention networks after cardiac surgery

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2015

Cortical Beta-amyloid Levels and Neurocognitive Performance After Cardiac Surgery

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2014

Pilot Study of the Feasibility of Multicenter NIRS Data Collection and Interventions for Desaturation in Cardiac Surgery

ResearchPrincipal Investigator · Awarded by Johns Hopkins University · 2013 - 2014

PeriOperative Interventional Neuroprotection Trial POINT

ResearchCo Investigator · Awarded by National Institutes of Health · 2001 - 2008

Genetics, Inflammation & Post-op Cognitive Dysfunction

ResearchCo Investigator · Awarded by National Institutes of Health · 1999 - 2006

Aging And Cognition After Cardiac Surgery

ResearchCo Investigator · Awarded by National Institutes of Health · 1999 - 2004

External Relationships


  • Clinetic (formerly MedBlue Data)
  • Morpheus Consortium Inc
  • Sapphire Health Innovation

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.