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CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.

Publication ,  Journal Article
James, ML; Troy, J; Nowacki, N; Komisarow, J; Swisher, CB; Tucker, K; Hatton, K; Babi, MA; Worrall, BB; Andrews, C; Woo, D; Kranz, PG ...
Published in: Neurocrit Care
February 2022

BACKGROUND: Endogenous apolipoprotein (apo) E mediates neuroinflammatory responses and recovery after brain injury. Exogenously administered apoE-mimetic peptides effectively penetrate the central nervous system compartment and downregulate acute inflammation. CN-105 is a novel apoE-mimetic pentapeptide with excellent evidence of functional and histological improvement in preclinical models of intracerebral hemorrhage (ICH). The CN-105 in participants with Acute supraTentorial intraCerebral Hemorrhage (CATCH) trial is a first-in-disease-state multicenter open-label trial evaluating safety and feasability of CN-105 administration in patients with acute primary supratentorial ICH. METHODS: Eligible patients were aged 30-80 years, had confirmed primary supratentorial ICH, and were able to intiate CN-105 administration (1.0 mg/kg every 6 h for 72 h) within 12 h of symptom onset. A priori defined safety end points, including hematoma volume, pharmacokinetics, and 30-day neurological outcomes, were analyzed. For clinical outcomes, CATCH participants were compared 1:1 with a closely matched contemporary ICH cohort through random selection. Hematoma volumes determined from computed tomography images on days 0, 1, 2, and 5 and ordinal modified Rankin Scale score at 30 days after ICH were compared. RESULTS: In 38 participants enrolled across six study sites in the United States, adverse events occurred at an expected rate without increase in hematoma expansion or neurological deterioration. CN-105 treatment had an odds ratio (95% confidence interval) of 2.69 (1.31-5.51) for lower 30-day modified Rankin Scale score, after adjustment for ICH score, sex, and race/ethnicity, as compared with a matched contemporary cohort. CONCLUSIONS: CN-105 administration represents an excellent translational candidate for treatment of acute ICH because of its safety, dosing feasibility, favorable pharmacokinetics, and possible improvement in neurological recovery.

Duke Scholars

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Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

February 2022

Volume

36

Issue

1

Start / End Page

216 / 225

Location

United States

Related Subject Headings

  • Odds Ratio
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Hematoma
  • Ethnicity
  • Cohort Studies
  • Cerebral Hemorrhage
  • Aged, 80 and over
  • Aged
 

Citation

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James, M. L., Troy, J., Nowacki, N., Komisarow, J., Swisher, C. B., Tucker, K., … CATCH Investigators, . (2022). CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial. Neurocrit Care, 36(1), 216–225. https://doi.org/10.1007/s12028-021-01287-0
James, Michael L., Jesse Troy, Nathaniel Nowacki, Jordan Komisarow, Christa B. Swisher, Kristi Tucker, Kevin Hatton, et al. “CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.Neurocrit Care 36, no. 1 (February 2022): 216–25. https://doi.org/10.1007/s12028-021-01287-0.
James ML, Troy J, Nowacki N, Komisarow J, Swisher CB, Tucker K, et al. CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial. Neurocrit Care. 2022 Feb;36(1):216–25.
James, Michael L., et al. “CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.Neurocrit Care, vol. 36, no. 1, Feb. 2022, pp. 216–25. Pubmed, doi:10.1007/s12028-021-01287-0.
James ML, Troy J, Nowacki N, Komisarow J, Swisher CB, Tucker K, Hatton K, Babi MA, Worrall BB, Andrews C, Woo D, Kranz PG, Lascola C, Maughan M, Laskowitz DT, CATCH Investigators. CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial. Neurocrit Care. 2022 Feb;36(1):216–225.
Journal cover image

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

February 2022

Volume

36

Issue

1

Start / End Page

216 / 225

Location

United States

Related Subject Headings

  • Odds Ratio
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Hematoma
  • Ethnicity
  • Cohort Studies
  • Cerebral Hemorrhage
  • Aged, 80 and over
  • Aged