BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.

Journal Article (Journal Article)

Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation and plasticity of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated. Furthermore, the age-dependent decline of cortical long-term potentiation induced by white matter stimulation, a form of synaptic plasticity sensitive to cortical inhibition, occurred earlier. Finally, transgenic mice showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity. We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.

Full Text

Duke Authors

Cited Authors

  • Huang, ZJ; Kirkwood, A; Pizzorusso, T; Porciatti, V; Morales, B; Bear, MF; Maffei, L; Tonegawa, S

Published Date

  • September 17, 1999

Published In

Volume / Issue

  • 98 / 6

Start / End Page

  • 739 - 755

PubMed ID

  • 10499792

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)81509-3


  • eng

Conference Location

  • United States