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BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.

Publication ,  Journal Article
Huang, ZJ; Kirkwood, A; Pizzorusso, T; Porciatti, V; Morales, B; Bear, MF; Maffei, L; Tonegawa, S
Published in: Cell
September 17, 1999

Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation and plasticity of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated. Furthermore, the age-dependent decline of cortical long-term potentiation induced by white matter stimulation, a form of synaptic plasticity sensitive to cortical inhibition, occurred earlier. Finally, transgenic mice showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity. We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

September 17, 1999

Volume

98

Issue

6

Start / End Page

739 / 755

Location

United States

Related Subject Headings

  • Visual Cortex
  • Visual Acuity
  • Transgenes
  • Tissue Distribution
  • Time Factors
  • Recombinant Proteins
  • Receptors, GABA
  • Pyramidal Cells
  • Prosencephalon
  • Perception
 

Citation

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Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., … Tonegawa, S. (1999). BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell, 98(6), 739–755. https://doi.org/10.1016/s0092-8674(00)81509-3
Huang, Z. J., A. Kirkwood, T. Pizzorusso, V. Porciatti, B. Morales, M. F. Bear, L. Maffei, and S. Tonegawa. “BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.Cell 98, no. 6 (September 17, 1999): 739–55. https://doi.org/10.1016/s0092-8674(00)81509-3.
Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, et al. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 1999 Sep 17;98(6):739–55.
Huang, Z. J., et al. “BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.Cell, vol. 98, no. 6, Sept. 1999, pp. 739–55. Pubmed, doi:10.1016/s0092-8674(00)81509-3.
Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 1999 Sep 17;98(6):739–755.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

September 17, 1999

Volume

98

Issue

6

Start / End Page

739 / 755

Location

United States

Related Subject Headings

  • Visual Cortex
  • Visual Acuity
  • Transgenes
  • Tissue Distribution
  • Time Factors
  • Recombinant Proteins
  • Receptors, GABA
  • Pyramidal Cells
  • Prosencephalon
  • Perception