Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases.

Journal Article (Journal Article;Review)

Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are signaling adaptors that critically regulate cell death and inflammation. Tumors have adapted to subvert RIPK-dependent cell death, suggesting that these processes have key roles in tumor regulation. Moreover, RIPK-driven cancer cell death might bolster durable antitumor immunity. By contrast, there are examples in which RIPKs induce inflammation and aid tumor progression. Furthermore, the RIPKs can exert their effects on tumor growth through regulating the activity of immune effectors in the tumor microenvironment, thus highlighting the context-dependent roles of RIPKs. Here, we review recent advances in the regulation of RIPK activity in tumors and immune cells and how these processes coordinate with each other to control tumorigenesis.

Full Text

Duke Authors

Cited Authors

  • Rucker, AJ; Chan, FK-M

Published Date

  • April 2022

Published In

Volume / Issue

  • 47 / 4

Start / End Page

  • 342 - 351

PubMed ID

  • 34998669

Pubmed Central ID

  • PMC8917977

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2021.12.004


  • eng

Conference Location

  • England