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Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases.

Publication ,  Journal Article
Rucker, AJ; Chan, FK-M
Published in: Trends Biochem Sci
April 2022

Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are signaling adaptors that critically regulate cell death and inflammation. Tumors have adapted to subvert RIPK-dependent cell death, suggesting that these processes have key roles in tumor regulation. Moreover, RIPK-driven cancer cell death might bolster durable antitumor immunity. By contrast, there are examples in which RIPKs induce inflammation and aid tumor progression. Furthermore, the RIPKs can exert their effects on tumor growth through regulating the activity of immune effectors in the tumor microenvironment, thus highlighting the context-dependent roles of RIPKs. Here, we review recent advances in the regulation of RIPK activity in tumors and immune cells and how these processes coordinate with each other to control tumorigenesis.

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

April 2022

Volume

47

Issue

4

Start / End Page

342 / 351

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Signal Transduction
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Neoplasms
  • Necrosis
  • Inflammation
  • Immunity
  • Humans
  • Developmental Biology
  • Cell Death
 

Citation

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Rucker, A. J., & Chan, F.-M. (2022). Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases. Trends Biochem Sci, 47(4), 342–351. https://doi.org/10.1016/j.tibs.2021.12.004
Rucker, A Justin, and Francis Ka-Ming Chan. “Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases.Trends Biochem Sci 47, no. 4 (April 2022): 342–51. https://doi.org/10.1016/j.tibs.2021.12.004.
Rucker AJ, Chan FK-M. Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases. Trends Biochem Sci. 2022 Apr;47(4):342–51.
Rucker, A. Justin, and Francis Ka-Ming Chan. “Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases.Trends Biochem Sci, vol. 47, no. 4, Apr. 2022, pp. 342–51. Pubmed, doi:10.1016/j.tibs.2021.12.004.
Rucker AJ, Chan FK-M. Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases. Trends Biochem Sci. 2022 Apr;47(4):342–351.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

April 2022

Volume

47

Issue

4

Start / End Page

342 / 351

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Signal Transduction
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Neoplasms
  • Necrosis
  • Inflammation
  • Immunity
  • Humans
  • Developmental Biology
  • Cell Death