Monocyte miRNAs Are Associated With Type 2 Diabetes.

Journal Article (Journal Article)

miRNAs are small noncoding RNAs that may contribute to common diseases through epigenetic regulation of gene expression. Little is known regarding the role of miRNAs in type 2 diabetes (T2D). We performed miRNA sequencing and transcriptomic profiling of peripheral monocytes from the longitudinal Multi-Ethnic Study of Atherosclerosis (MESA) (N = 1,154). We examined associations between miRNAs and prevalent impaired fasting glucose and T2D and evaluated the T2D-associated miRNA effect on incident T2D. Of 774 detected miRNAs, 6 (miR-22-3p, miR-33a-5p, miR-181c-5p, miR-92b-3p, miR-222-3p, and miR-944) were associated with prevalent T2D. For five of the six miRNAs (all but miR-222-3p), our findings suggest a dose-response relationship with impaired fasting glucose and T2D. Two of the six miRNAs were associated with incident T2D (miR-92b-3p: hazard ratio [HR] 1.64, P = 1.30E-03; miR-222-3p: HR 1.97, P = 9.10E-03) in the highest versus lowest tertile of expression. Most of the T2D-associated miRNAs were also associated with HDL cholesterol concentrations. The genes targeted by these miRNAs belong to key nodes of a cholesterol metabolism transcriptomic network. Higher levels of miRNA expression expected to increase intracellular cholesterol accumulation in monocytes are linked to an increase in T2D risk.

Full Text

Duke Authors

Cited Authors

  • Parker, DC; Wan, M; Lohman, K; Hou, L; Nguyen, AT; Ding, J; Bertoni, A; Shea, S; Burke, GL; Jacobs, DR; Post, W; Corcoran, D; Hoeschele, I; Parks, JS; Liu, Y

Published Date

  • April 1, 2022

Published In

Volume / Issue

  • 71 / 4

Start / End Page

  • 853 - 861

PubMed ID

  • 35073575

Pubmed Central ID

  • PMC8965663

Electronic International Standard Serial Number (EISSN)

  • 1939-327X

Digital Object Identifier (DOI)

  • 10.2337/db21-0704

Language

  • eng

Conference Location

  • United States