Daniel Christopher Parker

Daniel Christopher Parker
Assistant Professor of Medicine

Biological aging is the greatest risk factor for most chronic diseases, including frailty and dementia. The geroscience hypothesis posits that interventions that target aspects of biological aging may delay or prevent many of these diseases simultaneously. My research centers on understanding the mechanisms of interventions that affect biological aging, like exercise training and caloric restriction and using that understanding to develop therapies that maintain cognitive and physical function in older adults.

Current Research Interests

biological aging, geroscience, geroprotection, caloric restriction, exercise training, Alzheimer's disease and related dementias, age-related cognitive impairment

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Geriatrics, Medicine 2020

Contact Information

Rm 1510 Blue Zone Duke South, Box 3003, Durham, NC 27705
daniel.parker@duke.edu (919) 660-7692

Background
Education, Training, & Certifications
- Advanced Fellowship in Geriatric Medicine, Medicine, , 2016
- Post-Doctoral Research Fellowship, Duke Center For The Study Of Aging And Human Development, Duke University School of Medicine 2017 - 2019
- Internal Medicine Residency, Eastern Virginia Medical School 2013 - 2016
- M.D., Eastern Virginia Medical School 2013
Medical Licensure
- 2016-01485. North Carolina. 2016
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Geriatrics, Medicine 2019 - 2020
Recognition
Awards & Honors
- Poster Presentation Award of Recognition . 2019 Claude D. Pepper Older American Independence Centers Annual Meeting. April 2019
Research
Selected Grants
- Healthy Skeletal Muscle, Healthy Brain: Are Kynurenine Metabolites the Link? awarded by National Institutes of Health 2020 - 2022
- A Longitudinal Epigenetic Study of Atherosclerosis awarded by National Institutes of Health 2016 - 2021
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health 2017 - 2021
- The Effect of Exercise Type, Dose, and Intensity on Plasma Amyloid Beta and Tau in Healthy Adults awarded by Dementia Alliance of North Carolina 2019 - 2021
Fellowships, Supported Research, & Other Grants
- A Pilot Study to Investigate the Association of Measures of Biological Age with Outcomes after Coronary Artery Bypass Graft Surgery (CABG) awarded by Duke Center for Geriatric Surgery 2019 - 2020
- The Effect of Exercise Mode, Amount and Intensity on Plasma Markers of Brain Aging in Healthy Adults awarded by Dementia Alliance of North Carolina - Lina Mae Edwards Young Investigator Award 2019 - 2021
- A Pilot Study to Evaluate the Effect of Caloric Restriction on Plasma Markers of Brain Aging awarded by CALERIE Network Program Grant 2019 - 2020
- Connecting Agencies, Practices, and Seniors through a Trusted Online Network awarded by Duke Clinical and Translational Science Institute Population Health Award 2017 - 2018
External Relationships
- American Geriatrics Society
- American Geriatrics Society
- Oakland Innovation
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Parker, Daniel C., Bryce N. Bartlett, Harvey J. Cohen, Gerda Fillenbaum, Janet L. Huebner, Virginia Byers Kraus, Carl Pieper, and Daniel W. Belsky. “Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 9 (September 2020): 1671–79. https://doi.org/10.1093/gerona/glz219.
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  - Parker, Daniel C., Cathleen Colόn-Emeric, Janet L. Huebner, Ching-Heng Chou, Virginia Byers Kraus, Carl F. Pieper, Richard Sloane, et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 10 (September 2020): e166–72. https://doi.org/10.1093/gerona/glaa119.
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  - Colón-Emeric, Cathleen, Heather E. Whitson, Carl F. Pieper, Richard Sloane, Denise Orwig, Kim M. Huffman, Janet Prvu Bettger, et al. “Resiliency Groups Following Hip Fracture in Older Adults.” J Am Geriatr Soc 67, no. 12 (December 2019): 2519–27. https://doi.org/10.1111/jgs.16152.
    Full Text Link to Item
  - Parker, Daniel, Richard Sloane, Carl F. Pieper, Katherine S. Hall, Virginia B. Kraus, William E. Kraus, Janet L. Huebner, et al. “Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.” J Gerontol a Biol Sci Med Sci 74, no. 3 (February 15, 2019): 283–89. https://doi.org/10.1093/gerona/gly121.
    Full Text Open Access Copy Link to Item
  - Zhou, Jin, Daniel C. Parker, James P. White, Andrea Lim, Kim M. Huffman, Jia Pei Ho, Paul M. Yen, and William E. Kraus. “Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation.” Front Physiol 10 (2019): 1363. https://doi.org/10.3389/fphys.2019.01363.
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  - Morey, Miriam C., Cathy C. Lee, Steven Castle, Willy M. Valencia, Leslie Katzel, Jamie Giffuni, Teresa Kopp, et al. “Should Structured Exercise Be Promoted As a Model of Care? Dissemination of the Department of Veterans Affairs Gerofit Program.” J Am Geriatr Soc 66, no. 5 (May 2018): 1009–16. https://doi.org/10.1111/jgs.15276.
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  - Parker, Daniel C., Michelle M. Mielke, Qilu Yu, Paul B. Rosenberg, Alka Jain, Constantine G. Lyketsos, Neal S. Fedarko, and Esther S. Oh. “Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease.” International Journal of Geriatric Psychiatry 28, no. 2 (February 2013): 149–54. https://doi.org/10.1002/gps.3802.
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  - Archin, N. M., A. L. Liberty, A. D. Kashuba, S. K. Choudhary, J. D. Kuruc, A. M. Crooks, D. C. Parker, et al. “Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.” Nature 487, no. 7408 (July 26, 2012): 482–85. https://doi.org/10.1038/nature11286.
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  - Anderson, J. A., N. M. Archin, W. Ince, D. Parker, A. Wiegand, J. M. Coffin, J. Kuruc, J. Eron, R. Swanstrom, and D. M. Margolis. “Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells.” Journal of Virology 85, no. 10 (May 15, 2011): 5220–23. https://doi.org/10.1128/jvi.00284-11.
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  - Levesque, Marc C., M Anthony Moody, Kwan-Ki Hwang, Dawn J. Marshall, John F. Whitesides, Joshua D. Amos, Thaddeus C. Gurley, et al. “Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.” Plos Med 6, no. 7 (July 7, 2009): e1000107. https://doi.org/10.1371/journal.pmed.1000107.
    Full Text Open Access Copy Link to Item
  - Archin, Nancie M., Amy Espeseth, Daniel Parker, Manzoor Cheema, Daria Hazuda, and David M. Margolis. “Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid.” Aids Research and Human Retroviruses 25, no. 2 (February 2009): 207–12. https://doi.org/10.1089/aid.2008.0191.
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  - Archin, Nancie M., Manzoor Cheema, Daniel Parker, Ann Wiegand, Ronald J. Bosch, John M. Coffin, Joseph Eron, Myron Cohen, and David M. Margolis. “Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection.” Plos One 5, no. 2 (n.d.): e9390–e9390. https://doi.org/10.1371/journal.pone.0009390.
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- Book Sections
  - “Principles and Practice of Geriatric Surgery.” Springer International Publishing, 2017. https://doi.org/10.1007/978-3-319-20317-1.
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- Conference Papers
  - Parker, D. C., C. Colon-Emeric, and K. Huffman. “Biomarkers of Metabolic Dysregulation, Inflammation, and Cellular Senescence are Associated with Impaired Physical Resilience After Hip Fracture.” In Journal of the American Geriatrics Society, 68:S7–S7. WILEY, 2020.
    Link to Item
  - Parker, D. C., D. W. Belsky, and V. B. Kraus. “Quantifications of biological aging predict disability and mortality in older adults in the Duke EPESE.” In Journal of the American Geriatrics Society, 67:S145–S145. WILEY, 2019.
    Link to Item
  - Parker, D. C., J. Counts, G. Upchurch, M. Krol, and M. Heflin. “Evaluation of an Online Community Resource Referral Platform for Older Adults.” In Journal of the American Geriatrics Society, 67:S37–S37. WILEY, 2019.
    Link to Item
  - Parker, D. C., W. E. Kraus, C. Pieper, H. J. Cohen, and K. M. Huffman. “Data-Driven Cluster Analysis Identifies Unique Inflammatory and Metabolic Signatures Associated with Self-Rated Health, Cognitive Performance, and Function.” In Journal of the American Geriatrics Society, 67:S10–S10. WILEY, 2019.
    Link to Item
  - Parker, D. C., C. Hecht-Leavett, T. Cunningham, and H. Okhravi. “Visual Versus Automated Rating of Hippocampal Atrophy.” In Journal of the American Geriatrics Society, 65:S145–46. WILEY, 2017.
    Link to Item
  - Parker, D. C., K. Hall, M. Morey, and R. Sloane. “Sedentary Behavior is Associated with Elevations in Pro-Inflammatory Biomarkers.” In Journal of the American Geriatrics Society, 65:S119–S119. WILEY, 2017.
    Link to Item

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Education, Training, & Certifications

Medical Licensure

Duke Appointment History

Awards & Honors

Selected Grants

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers