Overview
My clinical and research interests center on the development and use of disease-modifying treatments for Alzheimer's disease and related dementias (ADRD). I am a regional leader in the use of amyloid targeted therapies (ATT), including lecanemab and donanemab, for the treatment of early Alzheimer's disease. I serve as director of the Duke Memory Disorders Clinic.
Current Appointments & Affiliations
Associate Professor of Medicine
·
2025 - Present
Medicine, Geriatrics and Palliative Care,
Medicine
Associate Professor in Neurology
·
2025 - Present
Neurology, Behavioral Neurology,
Neurology
Senior Fellow of the Center for the Study of Aging and Human Development
·
2020 - Present
Center for the Study of Aging and Human Development,
Institutes and Centers
Recent Publications
The Effect of Patient Age and Sex on Decision-Making Around An Alzheimer’s Disease Blood Test: QUIP II Study Results
Conference Innovation in Aging · December 1, 2025 AbstractBlood biomarker (BBM) tests for Alzheimer’s disease represent accurate and accessible tools to aid healthcare providers (HCPs) in the evaluation of patients presenting with signs or symptoms of mi ... Full text CiteCorrelating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer's disease and amnestic mild cognitive impairment.
Journal Article BMC Ophthalmol · July 1, 2025 BACKGROUND: We assess the relationships between retinal and choroidal structural and microvascular parameters and brain volumetric magnetic resonance imaging (MRI) parameters in individuals with amnestic mild cognitive impairment (aMCI) and Alzheimer's dis ... Full text Link to item CiteLXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes.
Journal Article J Clin Invest · August 15, 2024 Full text Link to item CiteRecent Grants
Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2021 - 2026Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative)
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2024Epigenetic Mechanisms Promoting Longevity
ResearchData Manager · Awarded by National Institutes of Health · 2018 - 2024View All Grants
Education
Eastern Virginia Medical School ·
2013
M.D.