Research Interests
Alzheimer's disease and related dementias, amyloid targeted treatments (ATT), Lewy body disease, blood-based biomarkers
Selected Grants
Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2021 - 2025Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative)
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2024Epigenetic Mechanisms Promoting Longevity
ResearchData Manager · Awarded by National Institutes of Health · 2018 - 2024Healthy Skeletal Muscle, Healthy Brain: Are Kynurenine Metabolites the Link?
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2023A Longitudinal Epigenetic Study of Atherosclerosis
ResearchScientist · Awarded by National Institutes of Health · 2020 - 2022The Effect of Exercise Type, Dose, and Intensity on Plasma Amyloid Beta and Tau in Healthy Adults
ResearchPrincipal Investigator · Awarded by Dementia Alliance of North Carolina · 2019 - 2021Fellowships, Gifts, and Supported Research
A Pilot Study to Investigate the Association of Measures of Biological Age with Outcomes after Coronary Artery Bypass Graft Surgery (CABG) ·
October 2019
- September 2020
Primary Investigator ·
Awarded by: Duke Center for Geriatric Surgery
· $25,000.00
This one-year project will determine whether patients presenting for elective CABG are biologically older than their chronological age. Biological age will be assessed using DNA-methylation based epigenetic age and clinical biomarker-derived measures. The impact of CABG on measures of biological age after six month follow up will also be determined.
The Effect of Exercise Mode, Amount and Intensity on Plasma Markers of Brain Aging in Healthy Adults ·
July 2019
- June 2021
Primary Investigator ·
Awarded by: Dementia Alliance of North Carolina - Lina Mae Edwards Young Investigator Award
· $100,000.00
This two-year project will determine the impact of exercise type, amount, and intensity on plasma Aβ42, Aβ40, total-tau, and NfL using an ultra-sensitive digital ELISA technology.
A Pilot Study to Evaluate the Effect of Caloric Restriction on Plasma Markers of Brain Aging ·
June 2019
- May 2020
Primary Investigator ·
Awarded by: CALERIE Network Program Grant
· $25,659.23
This two-year project will determine the impact of a two-year caloric restriction intervention on plasma Aβ42, Aβ40, total-tau, and NfL using an ultra-sensitive digital ELISA technology
Connecting Agencies, Practices, and Seniors through a Trusted Online Network ·
July 2017
- June 2018
Co-Investigator ·
Awarded by: Duke Clinical and Translational Science Institute Population Health Award
· $25,000.00
This one-year pilot project will evaluate the desirability and feasibility of a secure, online referral system for older adults and their caregivers, community-based organizations, and referring providers.
External Relationships
- Guidepoint
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.