Scholars@Duke
Daniel Christopher Parker

Daniel Christopher Parker

Associate Professor of Medicine
Medicine, Geriatrics and Palliative Care
daniel.parker@duke.edu
Rm 1510 Blue Zone Duke South, Box 3003, Durham, NC 27705

Selected Publications

LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes.

Journal Article J Clin Invest · May 15, 2024 BACKGROUNDPreclinical studies suggest that cholesterol accumulation leads to insulin resistance. We previously reported that alterations in a monocyte cholesterol metabolism transcriptional network (CMTN) - suggestive of cellular cholesterol accumulation - ... Full text Link to item Cite

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Some human studies have identified infection with cytomegalovirus (CMV), a member of the alpha herpesvirus family, as a risk factor for Alzheimer's disease and related dementias (ADRD). To our knowledge, no studies have evaluated associations o ... Full text Link to item Cite

Aqueous and Plasma Levels of Phosphorylated Tau 181 in Individuals with Normal Cognition.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Plasma and cerebrospinal fluid (CSF) levels of p-tau181 have been associated with Alzheimer's disease (AD). The retina and vitreous have shown measurable quantities of phosphorylated tau 181 (p-tau181). The aqueous humor, which can be collected ... Full text Link to item Cite

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Journal Article Nat Aging · March 2023 The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1-3. Caloric restriction (CR), defined as lessening caloric intake without ... Full text Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.

Journal Article Front Genet · 2023 Dysregulation of physiological processes may contribute to Alzheimer's disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilience and robustness ... Full text Link to item Cite

Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults.

Journal Article EBioMedicine · November 2022 BACKGROUND: The hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data. METHODS: Using a framework that combines loc ... Full text Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Field-Based Assessments of Behavioral Patterns During Shiftwork in Police Academy Trainees Using Wearable Technology.

Journal Article J Biol Rhythms · June 2022 Circadian misalignment, as occurs in shiftwork, is associated with numerous negative health outcomes. Here, we sought to improve data labeling accuracy from wearable technology using a novel data pre-processing algorithm in 27 police trainees during shiftw ... Full text Open Access Link to item Cite

Monocyte miRNAs Are Associated With Type 2 Diabetes.

Journal Article Diabetes · April 1, 2022 miRNAs are small noncoding RNAs that may contribute to common diseases through epigenetic regulation of gene expression. Little is known regarding the role of miRNAs in type 2 diabetes (T2D). We performed miRNA sequencing and transcriptomic profiling of pe ... Full text Link to item Cite

Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.

Journal Article EClinicalMedicine · January 2022 BACKGROUND: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metab ... Full text Link to item Cite

A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

Journal Article J Am Geriatr Soc · November 2021 BACKGROUND: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, ... Full text Link to item Cite

Two-Year Changes in Physical Activity Domains Across the Lifespan: Impact of Age and Gender

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · 2021 Cite

A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant.

Journal Article PLoS One · 2021 BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HCT) is an often curative intent treatment, however it is associated with significant gastrointestinal (GI) toxicity and treatment related mortality. Graft-versus-host disease is a significant ... Full text Link to item Cite

Biomarkers Associated with Physical Resilience After Hip Fracture.

Journal Article J Gerontol A Biol Sci Med Sci · September 25, 2020 BACKGROUND: Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derive ... Full text Link to item Cite

Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.

Journal Article J Gerontol A Biol Sci Med Sci · September 16, 2020 Quantification of biological aging has been proposed for population surveillance of age-related decline in system integrity and evaluation of geroprotective therapies. However, methods of quantifying biological aging have been little studied in geriatric p ... Full text Link to item Cite

Biology of Aging

Chapter · January 1, 2020 Principles distilled from geroscience, the scientific study of aging, can facilitate surgical decision making by identifying appropriate surgical candidates, anticipating surgical complications, and predicting functional outcomes. Theories of aging can be ... Full text Cite

Resiliency Groups Following Hip Fracture in Older Adults.

Journal Article J Am Geriatr Soc · December 2019 OBJECTIVES: Defining common patterns of recovery after an acute health stressor (resiliency groups) has both clinical and research implications. We sought to identify groups of patients with similar recovery patterns across 10 outcomes following hip fractu ... Full text Link to item Cite

Evaluation of an Online Community Resource Referral Platform for Older Adults

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2019 Link to item Cite

Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Journal Article J Gerontol A Biol Sci Med Sci · February 15, 2019 Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers ... Full text Open Access Link to item Cite

Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation.

Journal Article Front Physiol · 2019 Although both exercise and thyroid hormone (TH) status can cause cellular and metabolic changes in skeletal muscle, the impact of TH status on exercise-associated changes is not well understood. Here, we examined the effects of TH status on muscle fiber ty ... Full text Link to item Cite

Should Structured Exercise Be Promoted As a Model of Care? Dissemination of the Department of Veterans Affairs Gerofit Program.

Journal Article J Am Geriatr Soc · May 2018 Exercise provides a wide range of health-promoting benefits, but support is limited for clinical programs that use exercise as a means of health promotion. This stands in contrast to restorative or rehabilitative exercise, which is considered an essential ... Full text Link to item Cite

Biology of Aging

Chapter · July 5, 2017 Full text Cite

Sedentary Behavior is Associated with Elevations in Pro-Inflammatory Biomarkers

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · May 1, 2017 Link to item Cite

Visual Versus Automated Rating of Hippocampal Atrophy

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · May 1, 2017 Link to item Cite

Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease.

Journal Article Int J Geriatr Psychiatry · February 2013 OBJECTIVE: Alterations of the immune system play important roles in Alzheimer's disease (AD). The primary purpose of this study was to compare the plasma levels of neopterin, a marker of cellular immune activity, in amnestic mild cognitive impairment (aMCI ... Full text Link to item Cite

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.

Journal Article Nature · July 25, 2012 Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection. Inducing the expression of latent genomes within resting CD4(+) T cells is the primary strategy to clear t ... Full text Link to item Cite

Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells.

Journal Article J Virol · May 2011 Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate th ... Full text Link to item Cite

Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection.

Journal Article PLoS One · February 23, 2010 BACKGROUND: Human immunodeficiency virus (HIV) infection that persists despite antiretroviral therapy (ART) is a daunting problem. Given the limited evidence that resting CD4+ T cell infection (RCI) is affected by the histone deacetylase (HDAC) inhibitor v ... Full text Link to item Cite

Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.

Journal Article PLoS Med · July 7, 2009 BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreove ... Full text Open Access Link to item Cite

Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.

Journal Article AIDS Res Hum Retroviruses · February 2009 Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ... Full text Link to item Cite