Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field.

Journal Article (Journal Article)

Hyperpolarization methods in magnetic resonance overcome sensitivity limitations, especially for low-γ nuclei such as 13 C and 15 N. Signal Amplification By Reversible Exchange (SABRE) and extended SABRE (X-SABRE) are efficient and low-cost methods for generating large polarizations on a variety of nuclei, but they most commonly use low magnetic fields (μT-mT). High field approaches, where hyperpolarization is generated directly in the spectrometer, are potentially much more convenient but have been limited to selectively hyperpolarize single targets. Here we introduce a new pulse sequence-based approach that affords broadband excitation of SABRE hyperpolarization at high magnetic fields without having to tailor pulse sequence parameters to specific targets. This permits simultaneous hyperpolarization of multiple targets for the first time at high field and offers a direct approach to integration of high-field SABRE hyperpolarization into routine NMR applications, such as NMR-based metabonomics and biomolecular NMR.

Full Text

Duke Authors

Cited Authors

  • Lindale, JR; Eriksson, SL; Warren, WS

Published Date

  • March 2022

Published In

Volume / Issue

  • 24 / 12

Start / End Page

  • 7214 - 7223

PubMed ID

  • 35266466

Electronic International Standard Serial Number (EISSN)

  • 1463-9084

International Standard Serial Number (ISSN)

  • 1463-9076

Digital Object Identifier (DOI)

  • 10.1039/d1cp05962a

Language

  • eng