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Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field.

Publication ,  Journal Article
Lindale, JR; Eriksson, SL; Warren, WS
Published in: Physical chemistry chemical physics : PCCP
March 2022

Hyperpolarization methods in magnetic resonance overcome sensitivity limitations, especially for low-γ nuclei such as 13C and 15N. Signal Amplification By Reversible Exchange (SABRE) and extended SABRE (X-SABRE) are efficient and low-cost methods for generating large polarizations on a variety of nuclei, but they most commonly use low magnetic fields (μT-mT). High field approaches, where hyperpolarization is generated directly in the spectrometer, are potentially much more convenient but have been limited to selectively hyperpolarize single targets. Here we introduce a new pulse sequence-based approach that affords broadband excitation of SABRE hyperpolarization at high magnetic fields without having to tailor pulse sequence parameters to specific targets. This permits simultaneous hyperpolarization of multiple targets for the first time at high field and offers a direct approach to integration of high-field SABRE hyperpolarization into routine NMR applications, such as NMR-based metabonomics and biomolecular NMR.

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Published In

Physical chemistry chemical physics : PCCP

DOI

EISSN

1463-9084

ISSN

1463-9076

Publication Date

March 2022

Volume

24

Issue

12

Start / End Page

7214 / 7223

Related Subject Headings

  • Nuclear Magnetic Resonance, Biomolecular
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Magnetic Fields
  • Chemical Physics
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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Lindale, J. R., Eriksson, S. L., & Warren, W. S. (2022). Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field. Physical Chemistry Chemical Physics : PCCP, 24(12), 7214–7223. https://doi.org/10.1039/d1cp05962a
Lindale, Jacob R., Shannon L. Eriksson, and Warren S. Warren. “Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field.Physical Chemistry Chemical Physics : PCCP 24, no. 12 (March 2022): 7214–23. https://doi.org/10.1039/d1cp05962a.
Lindale JR, Eriksson SL, Warren WS. Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field. Physical chemistry chemical physics : PCCP. 2022 Mar;24(12):7214–23.
Lindale, Jacob R., et al. “Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field.Physical Chemistry Chemical Physics : PCCP, vol. 24, no. 12, Mar. 2022, pp. 7214–23. Epmc, doi:10.1039/d1cp05962a.
Lindale JR, Eriksson SL, Warren WS. Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field. Physical chemistry chemical physics : PCCP. 2022 Mar;24(12):7214–7223.
Journal cover image

Published In

Physical chemistry chemical physics : PCCP

DOI

EISSN

1463-9084

ISSN

1463-9076

Publication Date

March 2022

Volume

24

Issue

12

Start / End Page

7214 / 7223

Related Subject Headings

  • Nuclear Magnetic Resonance, Biomolecular
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Magnetic Fields
  • Chemical Physics
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences