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Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality.

Publication ,  Journal Article
Sullivan, BA; Qin, X; Miller, C; Hauser, ER; Redding, TS; Gellad, ZF; Madison, AN; Musselwhite, LW; Efird, JT; Sims, KJ; Williams, CD ...
Published in: Clin Transl Gastroenterol
April 1, 2022

INTRODUCTION: Controversy exists regarding the impact of various risk factors on noncolorectal cancer (CRC) mortality in healthy screening populations. We examined the impact of known CRC risk factors, including baseline colonoscopy findings, on non-CRC mortality in a screening population. METHODS: Cooperative Studies Program (CSP) #380 is comprised of 3,121 veterans aged 50-75 years who underwent screening colonoscopy from 1994 to 97 and were then followed for at least 10 years or until death. Hazard ratios (HRs) for risk factors on non-CRC mortality were estimated by multivariate Cox proportional hazards. RESULTS: Current smoking (HR 2.12, 95% confidence interval [CI] 1.78-2.52, compared with nonsmokers) and physical activity (HR 0.89, 95% CI 0.84-0.93) were the modifiable factors most associated with non-CRC mortality in CSP#380. In addition, compared with no neoplasia at baseline colonoscopy, non-CRC mortality was higher in participants with ≥3 small adenomas (HR 1.43, 95% CI 1.06-1.94), advanced adenomas (HR 1.32, 95% CI 0.99-1.75), and CRC (HR 2.95, 95% CI 0.98-8.85). Those with 1-2 small adenomas were not at increased risk for non-CRC mortality (HR 1.15, 95% CI 0.94-1.4). DISCUSSION: In a CRC screening population, known modifiable risk factors were significantly associated with 10-year non-CRC mortality. Furthermore, those who died from non-CRC causes within 10 years were more likely to have had high-risk findings at baseline colonoscopy. These results suggest that advanced colonoscopy findings may be a risk marker of poor health outcomes. Integrated efforts are needed to motivate healthy lifestyle changes during CRC screening, particularly in those with high-risk colonoscopy findings and unaddressed risk factors.

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Published In

Clin Transl Gastroenterol

DOI

EISSN

2155-384X

Publication Date

April 1, 2022

Volume

13

Issue

4

Start / End Page

e00479

Location

United States

Related Subject Headings

  • Mass Screening
  • Humans
  • Early Detection of Cancer
  • Colorectal Neoplasms
  • Colonoscopy
  • Adenoma
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Sullivan, B. A., Qin, X., Miller, C., Hauser, E. R., Redding, T. S., Gellad, Z. F., … Provenzale, D. (2022). Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality. Clin Transl Gastroenterol, 13(4), e00479. https://doi.org/10.14309/ctg.0000000000000479
Sullivan, Brian A., Xuejun Qin, Cameron Miller, Elizabeth R. Hauser, Thomas S. Redding, Ziad F. Gellad, Ashton N. Madison, et al. “Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality.Clin Transl Gastroenterol 13, no. 4 (April 1, 2022): e00479. https://doi.org/10.14309/ctg.0000000000000479.
Sullivan BA, Qin X, Miller C, Hauser ER, Redding TS, Gellad ZF, et al. Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality. Clin Transl Gastroenterol. 2022 Apr 1;13(4):e00479.
Sullivan, Brian A., et al. “Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality.Clin Transl Gastroenterol, vol. 13, no. 4, Apr. 2022, p. e00479. Pubmed, doi:10.14309/ctg.0000000000000479.
Sullivan BA, Qin X, Miller C, Hauser ER, Redding TS, Gellad ZF, Madison AN, Musselwhite LW, Efird JT, Sims KJ, Williams CD, Weiss D, Lieberman D, Provenzale D. Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality. Clin Transl Gastroenterol. 2022 Apr 1;13(4):e00479.

Published In

Clin Transl Gastroenterol

DOI

EISSN

2155-384X

Publication Date

April 1, 2022

Volume

13

Issue

4

Start / End Page

e00479

Location

United States

Related Subject Headings

  • Mass Screening
  • Humans
  • Early Detection of Cancer
  • Colorectal Neoplasms
  • Colonoscopy
  • Adenoma
  • 3202 Clinical sciences
  • 1103 Clinical Sciences