Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group.

Journal Article (Journal Article)

Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.

Full Text

Duke Authors

Cited Authors

  • Yassine, HN; Samieri, C; Livingston, G; Glass, K; Wagner, M; Tangney, C; Plassman, BL; Ikram, MA; Voigt, RM; Gu, Y; O'Bryant, S; Minihane, AM; Craft, S; Fink, HA; Judd, S; Andrieu, S; Bowman, GL; Richard, E; Albensi, B; Meyers, E; Khosravian, S; Solis, M; Carrillo, M; Snyder, H; Grodstein, F; Scarmeas, N; Schneider, LS

Published Date

  • July 2022

Published In

Volume / Issue

  • 3 / 7

Start / End Page

  • e501 - e512

PubMed ID

  • 35821792

Pubmed Central ID

  • PMC9273104

Electronic International Standard Serial Number (EISSN)

  • 2666-7568

Digital Object Identifier (DOI)

  • 10.1016/s2666-7568(22)00120-9


  • eng

Conference Location

  • England