Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome.

Journal Article (Journal Article;Review)

Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide. In the US, incidence varies by geographic location and race, with the highest incidence in the southwestern and southeastern states and among racial minorities such as Hispanic and Black individuals. Prognosis is also poorer among these populations. The observed ethnic disparities do not fully reflect differences in the prevalence of risk factors, e.g., for cirrhosis that may progress to liver cancer or from genetic predisposition. Likely substantial contributors to risk are environmental factors, including chemical and non-chemical stressors; yet, the paucity of mechanistic insights impedes prevention efforts. Here, we review the current literature and evaluate challenges to reducing liver cancer disparities. We also discuss the hypothesis that epigenetic mediators may provide biomarkers for early detection to support interventions that reduce disparities.

Full Text

Duke Authors

Cited Authors

  • Vidal, AC; Moylan, CA; Wilder, J; Grant, DJ; Murphy, SK; Hoyo, C

Published Date

  • 2022

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 959852 -

PubMed ID

  • 36072796

Pubmed Central ID

  • PMC9441658

International Standard Serial Number (ISSN)

  • 2234-943X

Digital Object Identifier (DOI)

  • 10.3389/fonc.2022.959852


  • eng

Conference Location

  • Switzerland