Molecular Mechanisms of Castrate-Resistant Prostate Cancer.
Journal Article (Journal Article;Review)
Despite newer therapies for castrate-resistant prostate cancer (CRPC), many patients do not experience a treatment response, and most eventually experience secondary resistance. Various androgen-receptor-related and alternative mechanisms of resistance in CRPC have been identified. This focus on understanding the molecular basis of therapeutic resistance, including lineage plasticity, neuroendocrine transformation, and a range of other implicated genomic alterations will hopefully inform decision-making in the care of this lethal cancer.
- Kotamarti, S; Armstrong, AJ; Polascik, TJ; Moul, JW
- November 2022
Volume / Issue
- 49 / 4
Start / End Page
- 615 - 626
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States