Skip to main content
Journal cover image

Vaccination induces HIV broadly neutralizing antibody precursors in humans.

Publication ,  Journal Article
Leggat, DJ; Cohen, KW; Willis, JR; Fulp, WJ; deCamp, AC; Kalyuzhniy, O; Cottrell, CA; Menis, S; Finak, G; Ballweber-Fleming, L; Srikanth, A ...
Published in: Science
December 2, 2022

Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine-priming candidate eOD-GT8 60mer adjuvanted with AS01B had a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science

DOI

EISSN

1095-9203

Publication Date

December 2, 2022

Volume

378

Issue

6623

Start / End Page

eadd6502

Location

United States

Related Subject Headings

  • Vaccination
  • Mutation
  • Male
  • Immunoglobulin Light Chains
  • Immunoglobulin Heavy Chains
  • Humans
  • HIV Infections
  • HIV Antibodies
  • Germ Cells
  • General Science & Technology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leggat, D. J., Cohen, K. W., Willis, J. R., Fulp, W. J., deCamp, A. C., Kalyuzhniy, O., … Schief, W. R. (2022). Vaccination induces HIV broadly neutralizing antibody precursors in humans. Science, 378(6623), eadd6502. https://doi.org/10.1126/science.add6502
Leggat, David J., Kristen W. Cohen, Jordan R. Willis, William J. Fulp, Allan C. deCamp, Oleksandr Kalyuzhniy, Christopher A. Cottrell, et al. “Vaccination induces HIV broadly neutralizing antibody precursors in humans.Science 378, no. 6623 (December 2, 2022): eadd6502. https://doi.org/10.1126/science.add6502.
Leggat DJ, Cohen KW, Willis JR, Fulp WJ, deCamp AC, Kalyuzhniy O, et al. Vaccination induces HIV broadly neutralizing antibody precursors in humans. Science. 2022 Dec 2;378(6623):eadd6502.
Leggat, David J., et al. “Vaccination induces HIV broadly neutralizing antibody precursors in humans.Science, vol. 378, no. 6623, Dec. 2022, p. eadd6502. Pubmed, doi:10.1126/science.add6502.
Leggat DJ, Cohen KW, Willis JR, Fulp WJ, deCamp AC, Kalyuzhniy O, Cottrell CA, Menis S, Finak G, Ballweber-Fleming L, Srikanth A, Plyler JR, Schiffner T, Liguori A, Rahaman F, Lombardo A, Philiponis V, Whaley RE, Seese A, Brand J, Ruppel AM, Hoyland W, Yates NL, Williams LD, Greene K, Gao H, Mahoney CR, Corcoran MM, Cagigi A, Taylor A, Brown DM, Ambrozak DR, Sincomb T, Hu X, Tingle R, Georgeson E, Eskandarzadeh S, Alavi N, Lu D, Mullen T-M, Kubitz M, Groschel B, Maenza J, Kolokythas O, Khati N, Bethony J, Crotty S, Roederer M, Karlsson Hedestam GB, Tomaras GD, Montefiori D, Diemert D, Koup RA, Laufer DS, McElrath MJ, McDermott AB, Schief WR. Vaccination induces HIV broadly neutralizing antibody precursors in humans. Science. 2022 Dec 2;378(6623):eadd6502.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

December 2, 2022

Volume

378

Issue

6623

Start / End Page

eadd6502

Location

United States

Related Subject Headings

  • Vaccination
  • Mutation
  • Male
  • Immunoglobulin Light Chains
  • Immunoglobulin Heavy Chains
  • Humans
  • HIV Infections
  • HIV Antibodies
  • Germ Cells
  • General Science & Technology