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The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.

Publication ,  Journal Article
Bradley, PX; Thomas, KN; Kratzer, AL; Robinson, AC; Wittstein, JR; DeFrate, LE; McNulty, AL
Published in: Curr Rheumatol Rep
February 2023

PURPOSE OF REVIEW: Meniscus injury often leads to joint degeneration and post-traumatic osteoarthritis (PTOA) development. Therefore, the purpose of this review is to outline the current understanding of biomechanical and biological repercussions following meniscus injury and how these changes impact meniscus repair and PTOA development. Moreover, we identify key gaps in knowledge that must be further investigated to improve meniscus healing and prevent PTOA. RECENT FINDINGS: Following meniscus injury, both biomechanical and biological alterations frequently occur in multiple tissues in the joint. Biomechanically, meniscus tears compromise the ability of the meniscus to transfer load in the joint, making the cartilage more vulnerable to increased strain. Biologically, the post-injury environment is often characterized by an increase in pro-inflammatory cytokines, catabolic enzymes, and immune cells. These multi-faceted changes have a significant interplay and result in an environment that opposes tissue repair and contributes to PTOA development. Additionally, degenerative changes associated with OA may cause a feedback cycle, negatively impacting the healing capacity of the meniscus. Strides have been made towards understanding post-injury biological and biomechanical changes in the joint, their interplay, and how they affect healing and PTOA development. However, in order to improve clinical treatments to promote meniscus healing and prevent PTOA development, there is an urgent need to understand the physiologic changes in the joint following injury. In particular, work is needed on the in vivo characterization of the temporal biomechanical and biological changes that occur in patients following meniscus injury and how these changes contribute to PTOA development.

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Published In

Curr Rheumatol Rep

DOI

EISSN

1534-6307

Publication Date

February 2023

Volume

25

Issue

2

Start / End Page

35 / 46

Location

United States

Related Subject Headings

  • Osteoarthritis
  • Meniscus
  • Humans
  • Cytokines
  • Cartilage, Articular
  • Arthroplasty, Replacement, Knee
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Bradley, P. X., Thomas, K. N., Kratzer, A. L., Robinson, A. C., Wittstein, J. R., DeFrate, L. E., & McNulty, A. L. (2023). The Interplay of Biomechanical and Biological Changes Following Meniscus Injury. Curr Rheumatol Rep, 25(2), 35–46. https://doi.org/10.1007/s11926-022-01093-3
Bradley, Patrick X., Karl N. Thomas, Avery L. Kratzer, Allison C. Robinson, Jocelyn R. Wittstein, Louis E. DeFrate, and Amy L. McNulty. “The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.Curr Rheumatol Rep 25, no. 2 (February 2023): 35–46. https://doi.org/10.1007/s11926-022-01093-3.
Bradley PX, Thomas KN, Kratzer AL, Robinson AC, Wittstein JR, DeFrate LE, et al. The Interplay of Biomechanical and Biological Changes Following Meniscus Injury. Curr Rheumatol Rep. 2023 Feb;25(2):35–46.
Bradley, Patrick X., et al. “The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.Curr Rheumatol Rep, vol. 25, no. 2, Feb. 2023, pp. 35–46. Pubmed, doi:10.1007/s11926-022-01093-3.
Bradley PX, Thomas KN, Kratzer AL, Robinson AC, Wittstein JR, DeFrate LE, McNulty AL. The Interplay of Biomechanical and Biological Changes Following Meniscus Injury. Curr Rheumatol Rep. 2023 Feb;25(2):35–46.
Journal cover image

Published In

Curr Rheumatol Rep

DOI

EISSN

1534-6307

Publication Date

February 2023

Volume

25

Issue

2

Start / End Page

35 / 46

Location

United States

Related Subject Headings

  • Osteoarthritis
  • Meniscus
  • Humans
  • Cytokines
  • Cartilage, Articular
  • Arthroplasty, Replacement, Knee
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences