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Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan.

Publication ,  Journal Article
Alder, L; Trapani, D; Bradbury, C; Van Swearingen, AED; Tolaney, SM; Khasraw, M; Anders, CK; Lascola, CD; Hsu, L; Lin, NU; Sammons, S
Published in: NPJ Breast Cancer
March 30, 2023

Leptomeningeal metastases (LM) are a devastating complication of HER2 + metastatic breast cancer (MBC), with no effective treatments. In a case series of 8 patients with heavily pretreated HER2 + MBC and progressing LM, all 8 patients (100%) derived clinical benefit from Trastuzumab deruxtecan (TDXd), and 4 patients (50%) had an objective partial response based on formal neuroradiology MRI reads using the EORTC/RANO-LM Revised-Scorecard. T-DXd warrants further study in LM in HER2 + MBC and solid tumors where T-DXd may be active.

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Published In

NPJ Breast Cancer

DOI

ISSN

2374-4677

Publication Date

March 30, 2023

Volume

9

Issue

1

Start / End Page

19

Location

United States

Related Subject Headings

  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Alder, L., Trapani, D., Bradbury, C., Van Swearingen, A. E. D., Tolaney, S. M., Khasraw, M., … Sammons, S. (2023). Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan. NPJ Breast Cancer, 9(1), 19. https://doi.org/10.1038/s41523-023-00519-0
Alder, Laura, Dario Trapani, Claire Bradbury, Amanda E. D. Van Swearingen, Sara M. Tolaney, Mustafa Khasraw, Carey K. Anders, et al. “Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan.NPJ Breast Cancer 9, no. 1 (March 30, 2023): 19. https://doi.org/10.1038/s41523-023-00519-0.
Alder L, Trapani D, Bradbury C, Van Swearingen AED, Tolaney SM, Khasraw M, et al. Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan. NPJ Breast Cancer. 2023 Mar 30;9(1):19.
Alder, Laura, et al. “Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan.NPJ Breast Cancer, vol. 9, no. 1, Mar. 2023, p. 19. Pubmed, doi:10.1038/s41523-023-00519-0.
Alder L, Trapani D, Bradbury C, Van Swearingen AED, Tolaney SM, Khasraw M, Anders CK, Lascola CD, Hsu L, Lin NU, Sammons S. Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan. NPJ Breast Cancer. 2023 Mar 30;9(1):19.

Published In

NPJ Breast Cancer

DOI

ISSN

2374-4677

Publication Date

March 30, 2023

Volume

9

Issue

1

Start / End Page

19

Location

United States

Related Subject Headings

  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences