The case for treatment of monogenic SRNS with calcineurin inhibitors.
Publication
, Journal Article
Lane, BM; Gbadegesin, RA
Published in: Kidney international
May 2023
Currently, no evidence-based guidelines exist for treatment of children with monogenic steroid-resistant nephrotic syndrome. A retrospective study on 141 patients from Malakasioti et al. revealed that 27.6% responded to calcineurin inhibitor (CNI) treatment, and 75% of responders maintained stable kidney function. Virtually all CNI nonresponders developed progressive loss of kidney function. This study emphasized roles for CNIs in patients with monogenic steroid-resistant nephrotic syndrome, and the need for future studies to identify CNI response biomarkers.
Duke Scholars
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Published In
Kidney international
DOI
EISSN
1523-1755
ISSN
0085-2538
Publication Date
May 2023
Volume
103
Issue
5
Start / End Page
839 / 841
Related Subject Headings
- Urology & Nephrology
- Retrospective Studies
- Nephrotic Syndrome
- Immunosuppressive Agents
- Humans
- Child
- Calcineurin Inhibitors
- Biomarkers
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lane, B. M., & Gbadegesin, R. A. (2023). The case for treatment of monogenic SRNS with calcineurin inhibitors. Kidney International, 103(5), 839–841. https://doi.org/10.1016/j.kint.2023.02.017
Lane, Brandon M., and Rasheed A. Gbadegesin. “The case for treatment of monogenic SRNS with calcineurin inhibitors.” Kidney International 103, no. 5 (May 2023): 839–41. https://doi.org/10.1016/j.kint.2023.02.017.
Lane BM, Gbadegesin RA. The case for treatment of monogenic SRNS with calcineurin inhibitors. Kidney international. 2023 May;103(5):839–41.
Lane, Brandon M., and Rasheed A. Gbadegesin. “The case for treatment of monogenic SRNS with calcineurin inhibitors.” Kidney International, vol. 103, no. 5, May 2023, pp. 839–41. Epmc, doi:10.1016/j.kint.2023.02.017.
Lane BM, Gbadegesin RA. The case for treatment of monogenic SRNS with calcineurin inhibitors. Kidney international. 2023 May;103(5):839–841.
Published In
Kidney international
DOI
EISSN
1523-1755
ISSN
0085-2538
Publication Date
May 2023
Volume
103
Issue
5
Start / End Page
839 / 841
Related Subject Headings
- Urology & Nephrology
- Retrospective Studies
- Nephrotic Syndrome
- Immunosuppressive Agents
- Humans
- Child
- Calcineurin Inhibitors
- Biomarkers
- 3202 Clinical sciences
- 1103 Clinical Sciences