Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.

Journal Article (Journal Article)

We describe the molecular cloning and characterization of a secreted, acidic, cysteine-rich glycoprotein (SPARC) of apparent Mr 43,000 which is a major product of mouse embryo parietal endoderm. These cells are specialized for the synthesis of a rapidly expanding basement membrane, but SPARC is not itself an integral matrix component. We show that SPARC is related structurally and antigenically to an Mr 43,000 glycoprotein secreted in large amounts by bovine aortic endothelial cells as part of a 'culture shock' response to in vitro conditions promoting their proliferation and migration.

Full Text

Duke Authors

Cited Authors

  • Mason, IJ; Taylor, A; Williams, JG; Sage, H; Hogan, BL

Published Date

  • July 1986

Published In

Volume / Issue

  • 5 / 7

Start / End Page

  • 1465 - 1472

PubMed ID

  • 3755680

Pubmed Central ID

  • PMC1166966

International Standard Serial Number (ISSN)

  • 0261-4189

Digital Object Identifier (DOI)

  • 10.1002/j.1460-2075.1986.tb04383.x


  • eng

Conference Location

  • England