Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.
Publication
, Journal Article
Mason, IJ; Taylor, A; Williams, JG; Sage, H; Hogan, BL
Published in: EMBO J
July 1986
We describe the molecular cloning and characterization of a secreted, acidic, cysteine-rich glycoprotein (SPARC) of apparent Mr 43,000 which is a major product of mouse embryo parietal endoderm. These cells are specialized for the synthesis of a rapidly expanding basement membrane, but SPARC is not itself an integral matrix component. We show that SPARC is related structurally and antigenically to an Mr 43,000 glycoprotein secreted in large amounts by bovine aortic endothelial cells as part of a 'culture shock' response to in vitro conditions promoting their proliferation and migration.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
EMBO J
DOI
ISSN
0261-4189
Publication Date
July 1986
Volume
5
Issue
7
Start / End Page
1465 / 1472
Location
England
Related Subject Headings
- Tumor Suppressor Proteins
- Transcription, Genetic
- Species Specificity
- Sequence Homology, Nucleic Acid
- Osteonectin
- Molecular Weight
- Molecular Sequence Data
- Mice
- Glycoproteins
- Endothelium
Citation
APA
Chicago
ICMJE
MLA
NLM
Mason, I. J., Taylor, A., Williams, J. G., Sage, H., & Hogan, B. L. (1986). Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J, 5(7), 1465–1472. https://doi.org/10.1002/j.1460-2075.1986.tb04383.x
Mason, I. J., A. Taylor, J. G. Williams, H. Sage, and B. L. Hogan. “Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.” EMBO J 5, no. 7 (July 1986): 1465–72. https://doi.org/10.1002/j.1460-2075.1986.tb04383.x.
Mason IJ, Taylor A, Williams JG, Sage H, Hogan BL. Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J. 1986 Jul;5(7):1465–72.
Mason, I. J., et al. “Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.” EMBO J, vol. 5, no. 7, July 1986, pp. 1465–72. Pubmed, doi:10.1002/j.1460-2075.1986.tb04383.x.
Mason IJ, Taylor A, Williams JG, Sage H, Hogan BL. Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J. 1986 Jul;5(7):1465–1472.
Published In
EMBO J
DOI
ISSN
0261-4189
Publication Date
July 1986
Volume
5
Issue
7
Start / End Page
1465 / 1472
Location
England
Related Subject Headings
- Tumor Suppressor Proteins
- Transcription, Genetic
- Species Specificity
- Sequence Homology, Nucleic Acid
- Osteonectin
- Molecular Weight
- Molecular Sequence Data
- Mice
- Glycoproteins
- Endothelium