Regulatory gene networks and the properties of the developmental process.

Journal Article (Journal Article)

Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.

Full Text

Duke Authors

Cited Authors

  • Davidson, EH; McClay, DR; Hood, L

Published Date

  • February 2003

Published In

Volume / Issue

  • 100 / 4

Start / End Page

  • 1475 - 1480

PubMed ID

  • 12578984

Pubmed Central ID

  • PMC149855

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0437746100


  • eng