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Regulatory gene networks and the properties of the developmental process.

Publication ,  Journal Article
Davidson, EH; McClay, DR; Hood, L
Published in: Proceedings of the National Academy of Sciences of the United States of America
February 2003

Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.

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Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

February 2003

Volume

100

Issue

4

Start / End Page

1475 / 1480

Related Subject Headings

  • Genome
  • Embryonic and Fetal Development
  • DNA
  • Animals
 

Citation

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Davidson, E. H., McClay, D. R., & Hood, L. (2003). Regulatory gene networks and the properties of the developmental process. Proceedings of the National Academy of Sciences of the United States of America, 100(4), 1475–1480. https://doi.org/10.1073/pnas.0437746100
Davidson, Eric H., David R. McClay, and Leroy Hood. “Regulatory gene networks and the properties of the developmental process.Proceedings of the National Academy of Sciences of the United States of America 100, no. 4 (February 2003): 1475–80. https://doi.org/10.1073/pnas.0437746100.
Davidson EH, McClay DR, Hood L. Regulatory gene networks and the properties of the developmental process. Proceedings of the National Academy of Sciences of the United States of America. 2003 Feb;100(4):1475–80.
Davidson, Eric H., et al. “Regulatory gene networks and the properties of the developmental process.Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 4, Feb. 2003, pp. 1475–80. Epmc, doi:10.1073/pnas.0437746100.
Davidson EH, McClay DR, Hood L. Regulatory gene networks and the properties of the developmental process. Proceedings of the National Academy of Sciences of the United States of America. 2003 Feb;100(4):1475–1480.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

February 2003

Volume

100

Issue

4

Start / End Page

1475 / 1480

Related Subject Headings

  • Genome
  • Embryonic and Fetal Development
  • DNA
  • Animals