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Inflammatory mechanisms in diabetes: lessons from the beta-cell.

Publication ,  Journal Article
Hohmeier, HE; Tran, VV; Chen, G; Gasa, R; Newgard, CB
Published in: Int J Obes Relat Metab Disord
December 2003

Inflammation plays an important role in the destruction of pancreatic islet beta-cells that leads to type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local production of inflammatory cytokines such as interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma. Our laboratory has developed several strategies for protecting beta-cells against oxidative stress and cytokine-induced cytotoxicity. These include a cytokine selection strategy that results in cell lines that are resistant to the combined effects of IL-1 beta+IFN-gamma. More recently, we have combined the cytokine selection procedure with overexpression of the antiapoptotic gene bcl-2, resulting in cell lines with greater resistance to oxidative stress and cytokine-induced damage than achieved with either procedure alone. This article summarizes this work and the remarkably divergent mechanisms by which protection is achieved in the different model systems. We also discuss the potential relevance of insights gained from these approaches for enhancing islet cell survival and function in both major forms of diabetes.

Duke Scholars

Published In

Int J Obes Relat Metab Disord

DOI

Publication Date

December 2003

Volume

27 Suppl 3

Start / End Page

S12 / S16

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Pancreatic Neoplasms
  • Islets of Langerhans
  • Insulinoma
  • Humans
  • Endocrinology & Metabolism
  • Diabetes Mellitus
  • Cytokines
  • Cell Survival
  • Apoptosis
 

Citation

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ICMJE
MLA
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Hohmeier, H. E., Tran, V. V., Chen, G., Gasa, R., & Newgard, C. B. (2003). Inflammatory mechanisms in diabetes: lessons from the beta-cell. Int J Obes Relat Metab Disord, 27 Suppl 3, S12–S16. https://doi.org/10.1038/sj.ijo.0802493
Hohmeier, H. E., V. V. Tran, G. Chen, R. Gasa, and C. B. Newgard. “Inflammatory mechanisms in diabetes: lessons from the beta-cell.Int J Obes Relat Metab Disord 27 Suppl 3 (December 2003): S12–16. https://doi.org/10.1038/sj.ijo.0802493.
Hohmeier HE, Tran VV, Chen G, Gasa R, Newgard CB. Inflammatory mechanisms in diabetes: lessons from the beta-cell. Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S12–6.
Hohmeier, H. E., et al. “Inflammatory mechanisms in diabetes: lessons from the beta-cell.Int J Obes Relat Metab Disord, vol. 27 Suppl 3, Dec. 2003, pp. S12–16. Pubmed, doi:10.1038/sj.ijo.0802493.
Hohmeier HE, Tran VV, Chen G, Gasa R, Newgard CB. Inflammatory mechanisms in diabetes: lessons from the beta-cell. Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S12–S16.

Published In

Int J Obes Relat Metab Disord

DOI

Publication Date

December 2003

Volume

27 Suppl 3

Start / End Page

S12 / S16

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Pancreatic Neoplasms
  • Islets of Langerhans
  • Insulinoma
  • Humans
  • Endocrinology & Metabolism
  • Diabetes Mellitus
  • Cytokines
  • Cell Survival
  • Apoptosis