Current Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Sarah W. Stedman Nutrition and Metabolism Center
·
2002 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease.
Journal Article J Clin Invest · January 16, 2024 Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and ... Full text Open Access Link to item CiteIdentification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
Journal Article PLoS One · 2020 A key event in the development of both major forms of diabetes is the loss of functional pancreatic islet β-cell mass. Strategies aimed at enhancing β-cell regeneration have long been pursued, but methods for reliably inducing human β-cell proliferation wi ... Full text Link to item CiteImproving human β-cell maturation in vitro.
Journal Article Nat Cell Biol · February 2019 Full text Link to item CiteRecent Grants
Development of small molecules for islet beta-cell regeneration and diabetes therapy
ResearchInvestigator · Awarded by University of Michigan · 2019 - 2023Small molecules with pleiotropic positive effects on beta-cell health
ResearchPrincipal Investigator · Awarded by Eli Lilly and Company · 2019 - 2022Pilot Study: Testing of Comprehensive Mitochondrial Profiling Platform in Islet cells
ResearchPrincipal Investigator · Awarded by Eli Lilly and Company · 2020 - 2022View All Grants
Education, Training & Certifications
Georg August Universitat Gottingen (Germany) ·
1992
Ph.D.
University of Hannover (Germany) ·
1986
M.D.