Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Biochemistry, UT Southwestern Medical School 1995 - 1997
  • Postdoctoral Fellow, Immunology, UT Southwestern Medical School 1991 - 1995
  • Ph.D., Georg August Universitat Gottingen (Germany) 1992
  • M.D., University of Hannover (Germany) 1986
• 

  Duke Appointment History

  • Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006 - 2017
  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
• Research
• 

  Selected Grants

  • Small molecules with pleiotropic positive effects on beta-cell health 2019 - 2020
  • Networks of nutritional stress in human pancreatic islet cells 2018 - 2019
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation 2017 - 2019
  • Biochemical Mechanisms of NNMT Inhibitors 2017 - 2018
  • HIRN UCSD 2017 - 2018
  • Physiology of SC-derived Human Beta Cells awarded by  Harvard University 2016 - 2017
  • Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication awarded by Mount Sinai School of Medicine 2013 - 2015
  • Engineering of Immunoprotection in B-Cell Lines awarded by National Institutes of Health 2002 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hohmeier, Hans E., Jie An, and Christopher B. Newgard. “Improving human β-cell maturation in vitro..” Nat Cell Biol 21, no. 2 (February 2019): 119–21. https://doi.org/10.1038/s41556-019-0277-6.
       Full Text  Link to Item
    • Hayes, Heather L., Brett S. Peterson, Jonathan M. Haldeman, Christopher B. Newgard, Hans E. Hohmeier, and Samuel B. Stephens. “Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival..” Plos One 12, no. 2 (2017). https://doi.org/10.1371/journal.pone.0172567.
       Full Text  Link to Item
    • Hayes, Heather L., Lu Zhang, Thomas C. Becker, Jonathan M. Haldeman, Samuel B. Stephens, Michelle Arlotto, Larry G. Moss, Christopher B. Newgard, and Hans E. Hohmeier. “A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation..” Mol Cell Biol 36, no. 23 (December 1, 2016): 2918–30. https://doi.org/10.1128/MCB.00103-16.
       Full Text  Link to Item
    • Shang, Jin, Jing Li, Mark P. Keller, Hans E. Hohmeier, Yong Wang, Yue Feng, Heather H. Zhou, et al. “Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells..” Mol Endocrinol 29, no. 9 (September 2015): 1243–53. https://doi.org/10.1210/me.2014-1335.
       Full Text  Link to Item
    • Lorenzo, Damaris N., Jane A. Healy, Janell Hostettler, Jonathan Davis, Jiayu Yang, Chao Wang, Hans Ewald Hohmeier, Mingjie Zhang, and Vann Bennett. “Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency..” J Clin Invest 125, no. 8 (August 3, 2015): 3087–3102. https://doi.org/10.1172/JCI81317.
       Full Text  Link to Item
    • Tessem, Jeffery S., Larry G. Moss, Lily C. Chao, Michelle Arlotto, Danhong Lu, Mette V. Jensen, Samuel B. Stephens, Peter Tontonoz, Hans E. Hohmeier, and Christopher B. Newgard. “Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors..” Proc Natl Acad Sci U S A 111, no. 14 (April 8, 2014): 5242–47. https://doi.org/10.1073/pnas.1320953111.
       Full Text  Link to Item
    • Hayes, Heather L., Larry G. Moss, Jonathan C. Schisler, Jonathan M. Haldeman, Zhushan Zhang, Paul B. Rosenberg, Christopher B. Newgard, and Hans E. Hohmeier. “Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2..” Mol Cell Biol 33, no. 20 (October 2013): 4017–29. https://doi.org/10.1128/MCB.00469-13.
       Full Text  Link to Item
    • Jensen, Mette V., Jonathan M. Haldeman, Hengtao Zhang, Danhong Lu, Mark O. Huising, Wylie W. Vale, Hans E. Hohmeier, Paul Rosenberg, and Christopher B. Newgard. “Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion..” J Biol Chem 288, no. 32 (August 9, 2013): 23128–40. https://doi.org/10.1074/jbc.M113.491654.
       Full Text  Link to Item
    • Li, Xiaoyan Nina, James Herrington, Aleksandr Petrov, Lan Ge, George Eiermann, Yusheng Xiong, Mette V. Jensen, et al. “The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets..” J Pharmacol Exp Ther 344, no. 2 (February 2013): 407–16. https://doi.org/10.1124/jpet.112.199083.
       Full Text  Link to Item
    • Stephens, Samuel B., Jonathan C. Schisler, Hans E. Hohmeier, Jie An, Albert Y. Sun, Geoffrey S. Pitt, and Christopher B. Newgard. “A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function..” Cell Metab 16, no. 1 (July 3, 2012): 33–43. https://doi.org/10.1016/j.cmet.2012.05.011.
       Full Text  Link to Item
    • Lemaire, Katleen, Rodrigo F. Moura, Mikaela Granvik, Mariana Igoillo-Esteve, Hans E. Hohmeier, Nico Hendrickx, Christopher B. Newgard, Etienne Waelkens, Miriam Cnop, and Frans Schuit. “Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis..” Plos One 6, no. 4 (April 6, 2011). https://doi.org/10.1371/journal.pone.0018517.
       Full Text  Link to Item
    • Healy, Jane A., Kent R. Nilsson, Hans E. Hohmeier, Jelena Berglund, Jonathan Davis, Janis Hoffman, Martin Kohler, et al. “Cholinergic augmentation of insulin release requires ankyrin-B..” Sci Signal 3, no. 113 (March 16, 2010). https://doi.org/10.1126/scisignal.2000771.
       Full Text  Link to Item
    • Malakauskas, Sandra M., Wissam M. Kourany, Xiao Yin Zhang, Danhong Lu, Robert D. Stevens, Timothy R. Koves, Hans E. Hohmeier, Deborah M. Muoio, Christopher B. Newgard, and Thu H. Le. “Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha..” Mol Endocrinol 23, no. 6 (June 2009): 881–92. https://doi.org/10.1210/me.2008-0274.
       Full Text  Link to Item
    • Schnedl, Wolfgang J., Claudia Piswanger-Soelkner, Sandra J. Wallner, Pia Reittner, Robert Krause, Rainer W. Lipp, and Hans E. Hohmeier. “Agenesis of the dorsal pancreas and associated diseases..” Dig Dis Sci 54, no. 3 (March 2009): 481–87. https://doi.org/10.1007/s10620-008-0370-3.
       Full Text  Link to Item
    • Ronnebaum, Sarah M., Mette V. Jensen, Hans E. Hohmeier, Shawn C. Burgess, Yun-Ping Zhou, Su Qian, Douglas MacNeil, et al. “Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets..” J Biol Chem 283, no. 43 (October 24, 2008): 28909–17. https://doi.org/10.1074/jbc.M804665200.
       Full Text  Link to Item
    • Fueger, Patrick T., Jonathan C. Schisler, Danhong Lu, Daniella A. Babu, Raghavendra G. Mirmira, Christopher B. Newgard, and Hans E. Hohmeier. “Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function..” Mol Endocrinol 22, no. 5 (May 2008): 1251–59. https://doi.org/10.1210/me.2007-0500.
       Full Text  Link to Item
    • Schisler, Jonathan C., Patrick T. Fueger, Daniella A. Babu, Hans E. Hohmeier, Jeffery S. Tessem, Danhong Lu, Thomas C. Becker, et al. “Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1..” Mol Cell Biol 28, no. 10 (May 2008): 3465–76. https://doi.org/10.1128/MCB.01791-07.
       Full Text  Link to Item
    • Hardy, Olga T., Hans E. Hohmeier, Thomas C. Becker, Elisabetta Manduchi, Nicolai M. Doliba, Rana K. Gupta, Peter White, et al. “Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents..” Mol Endocrinol 21, no. 3 (March 2007): 765–73. https://doi.org/10.1210/me.2006-0411.
       Full Text  Link to Item
    • Chen, Shuyuan, Jia-huan Ding, Raffi Bekeredjian, Bing-zhi Yang, Ralph V. Shohet, Stephen A. Johnston, Hans E. Hohmeier, Christopher B. Newgard, and Paul A. Grayburn. “Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology..” Proc Natl Acad Sci U S A 103, no. 22 (May 30, 2006): 8469–74. https://doi.org/10.1073/pnas.0602921103.
       Full Text  Link to Item
    • Collier, J Jason, Patrick T. Fueger, Hans E. Hohmeier, and Christopher B. Newgard. “Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines..” Diabetes 55, no. 5 (May 2006): 1398–1406. https://doi.org/10.2337/db05-1000.
       Full Text  Link to Item
    • Hohmeier, Hans E., and Christopher B. Newgard. “Islets for all?.” Nat Biotechnol 23, no. 10 (October 2005): 1231–32. https://doi.org/10.1038/nbt1005-1231.
       Full Text  Link to Item
    • Hohmeier, Hans E., and Christopher B. Newgard. “Cell lines derived from pancreatic islets..” Mol Cell Endocrinol 228, no. 1–2 (December 30, 2004): 121–28. https://doi.org/10.1016/j.mce.2004.04.017.
       Full Text  Link to Item
    • Yang, Shumin, Ulrika Fransson, Lillian Fagerhus, Lena Stenson Holst, Hans E. Hohmeier, Erik Renström, and Hindrik Mulder. “Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13)..” Mol Endocrinol 18, no. 9 (September 2004): 2312–20. https://doi.org/10.1210/me.2004-0148.
       Full Text  Link to Item
    • Newgard, Christopher B., Hans E. Hohmeier, Danhong Lu, Mette Valentin Jensen, Veronique V. Tran, Guoxun Chen, Shawn Burgess, and A Dean Sherry. “Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies..” Cell Biochem Biophys 40, no. 3 Suppl (2004): 159–68.
       Link to Item
    • Hohmeier, H. E., V. V. Tran, G. Chen, R. Gasa, and C. B. Newgard. “Inflammatory mechanisms in diabetes: lessons from the beta-cell..” Int J Obes Relat Metab Disord 27 Suppl 3 (December 2003): S12–16. https://doi.org/10.1038/sj.ijo.0802493.
       Full Text  Link to Item
    • Tran, Veronique Vien, Guoxun Chen, Christopher B. Newgard, and Hans E. Hohmeier. “Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy..” Diabetes 52, no. 6 (June 2003): 1423–32. https://doi.org/10.2337/diabetes.52.6.1423.
       Full Text  Link to Item
    • Chen, G., H. E. Hohmeier, and C. B. Newgard. “Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines..” J Biol Chem 276, no. 1 (January 5, 2001): 766–72. https://doi.org/10.1074/jbc.M008330200.
       Full Text  Link to Item
    • Chen, G., H. E. Hohmeier, R. Gasa, V. V. Tran, and C. B. Newgard. “Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity..” Diabetes 49, no. 4 (April 2000): 562–70. https://doi.org/10.2337/diabetes.49.4.562.
       Full Text  Link to Item
    • Hohmeier, H. E., H. Mulder, G. Chen, R. Henkel-Rieger, M. Prentki, and C. B. Newgard. “Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion..” Diabetes 49, no. 3 (March 2000): 424–30. https://doi.org/10.2337/diabetes.49.3.424.
       Full Text  Link to Item
    • Hohmeier, H. E., A. Thigpen, V. V. Tran, R. Davis, and C. B. Newgard. “Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production..” J Clin Invest 101, no. 9 (May 1, 1998): 1811–20. https://doi.org/10.1172/JCI1489.
       Full Text  Link to Item
    • Newgard, C. B., S. Clark, H. BeltrandelRio, H. E. Hohmeier, C. Quaade, and K. Normington. “Engineered cell lines for insulin replacement in diabetes: current status and future prospects..” Diabetologia 40 Suppl 2 (July 1997): S42–47.
       Link to Item
    • Hohmeier, H. E., H. BeltrandelRio, S. A. Clark, R. Henkel-Rieger, K. Normington, and C. B. Newgard. “Regulation of insulin secretion from novel engineered insulinoma cell lines..” Diabetes 46, no. 6 (June 1997): 968–77. https://doi.org/10.2337/diab.46.6.968.
       Full Text  Link to Item
    • Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “Insulinsezernierende Zellen zur Therapie des Diabetes mellitus.” Naturwissenschaften 83, no. 1 (December 1, 1996): 1–5.
    • Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “[Insulin producing cells as therapy in diabetes mellitus]..” Naturwissenschaften 83, no. 1 (January 1996): 1–5.
       Link to Item
    • Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “Insulin secretory cells for the therapy of diabetes mellitus.” Naturwissenschaften 83, no. 1 (1996): 1–5. https://doi.org/10.1007/s001140050238.
       Full Text
    • König, U., H. Götz, G. Walter, D. Babel, H. E. Hohmeier, F. P. Thinnes, and N. Hilschmann. “[Studies on human porin. V. The expression of "porin31HL" in the plasmalemma is not by cell transformation]..” Biol Chem Hoppe Seyler 372, no. 8 (August 1991): 565–72.
       Link to Item
    • König, U., H. Götz, G. Walter, D. Babel, H. E. Hohmeier, F. P. Thinnes, and N. Hilschmann. “Studies on human porin. V. The expression of "porin31HL" in the plasmalemma is not by cell transformation.” Biological Chemistry Hoppe Seyler 372, no. 8 (1991): 565–72.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.