Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Biochemistry, UT Southwestern Medical School 1995 - 1997
  • Postdoctoral Fellow, Immunology, UT Southwestern Medical School 1991 - 1995
  • Ph.D., Georg August Universitat Gottingen (Germany) 1992
  • M.D., University of Hannover (Germany) 1986
• 

  Duke Appointment History

  • Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006 - 2017
  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
• Research
• 

  Selected Grants

  • Networks of nutritional stress in human pancreatic islet cells awarded by Merck Sharp & Dohme 2018 - 2019
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2019
  • Biochemical Mechanisms of NNMT Inhibitors awarded by Eli Lilly and Company 2017 - 2018
  • HIRN UCSD awarded by University of California - San Diego 2017 - 2018
  • Physiology of SC-derived Human Beta Cells awarded by  Harvard University 2016 - 2017
  • Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication awarded by Mount Sinai School of Medicine 2013 - 2015
  • Engineering of Immunoprotection in B-Cell Lines awarded by National Institutes of Health 2002 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Hayes, HL, Peterson, BS, Haldeman, JM, Newgard, CB, Hohmeier, HE, and Stephens, SB. "Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival." PloS one 12, no. 2 (January 2017): e0172567-.  Full Text
    • Hayes, HL, Zhang, L, Becker, TC, Haldeman, JM, Stephens, SB, Arlotto, M, Moss, LG, Newgard, CB, and Hohmeier, HE. "A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation." Molecular and Cellular Biology 36, no. 23 (December 2016): 2918-2930.  Full Text
    • Shang, J, Li, J, Keller, MP, Hohmeier, HE, Wang, Y, Feng, Y, Zhou, HH, Shen, X, Rabaglia, M, Soni, M, Attie, AD, Newgard, CB, Thornberry, NA, Howard, AD, and Zhou, Y-P. "Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells." Molecular Endocrinology (Baltimore, Md.) 29, no. 9 (September 2015): 1243-1253.  Full Text
    • Lorenzo, DN, Healy, JA, Hostettler, J, Davis, J, Yang, J, Wang, C, Hohmeier, HE, Zhang, M, and Bennett, V. "Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency." The Journal of Clinical Investigation 125, no. 8 (August 2015): 3087-3102.  Full Text
    • Tessem, JS, Moss, LG, Chao, LC, Arlotto, M, Lu, D, Jensen, MV, Stephens, SB, Tontonoz, P, Hohmeier, HE, and Newgard, CB. "Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors." Proceedings of the National Academy of Sciences of the United States of America 111, no. 14 (April 2014): 5242-5247.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 Activates Islet α- and β-Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 25, 2013): 4017-4029.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 2013): 4017-4029.  Full Text
    • Jensen, MV, Haldeman, JM, Zhang, H, Lu, D, Huising, MO, Vale, WW, Hohmeier, HE, Rosenberg, P, and Newgard, CB. "Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion." J Biol Chem 288, no. 32 (August 9, 2013): 23128-23140.  Full Text  Link to Item
    • Li, XN, Herrington, J, Petrov, A, Ge, L, Eiermann, G, Xiong, Y, Jensen, MV, Hohmeier, HE, Newgard, CB, Garcia, ML, Wagner, M, Zhang, BB, Thornberry, NA, Howard, AD, Kaczorowski, GJ, and Zhou, Y-P. "The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets." The Journal of Pharmacology and Experimental Therapeutics 344, no. 2 (February 2013): 407-416.  Full Text
    • Stephens, SB, Schisler, JC, Hohmeier, HE, An, J, Sun, AY, Pitt, GS, and Newgard, CB. "A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function." Cell Metab 16, no. 1 (July 3, 2012): 33-43.  Full Text  Link to Item
    • Lemaire, K, Moura, RF, Granvik, M, Igoillo-Esteve, M, Hohmeier, HE, Hendrickx, N, Newgard, CB, Waelkens, E, Cnop, M, and Schuit, F. "Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis." Plos One 6, no. 4 (January 2011): e18517-null.  Full Text
    • Healy, JA, Nilsson, KR, Hohmeier, HE, Berglund, J, Davis, J, Hoffman, J, Kohler, M, Li, L-S, Berggren, P-O, Newgard, CB, and Bennett, V. "Cholinergic augmentation of insulin release requires ankyrin-B." Science Signaling 3, no. 113 (March 16, 2010): ra19-null.  Full Text
    • Malakauskas, SM, Kourany, WM, Zhang, XY, Lu, D, Stevens, RD, Koves, TR, Hohmeier, HE, Muoio, DM, Newgard, CB, and Le, TH. "Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha." Mol Endocrinol 23, no. 6 (June 2009): 881-892.  Full Text  Link to Item
    • Schnedl, WJ, Piswanger-Soelkner, C, Wallner, SJ, Reittner, P, Krause, R, Lipp, RW, and Hohmeier, HE. "Agenesis of the dorsal pancreas and associated diseases." Digestive Diseases and Sciences 54, no. 3 (2009): 481-487.  Full Text
    • Ronnebaum, SM, Jensen, MV, Hohmeier, HE, Burgess, SC, Zhou, Y-P, Qian, S, MacNeil, D, Howard, A, Thornberry, N, Ilkayeva, O, Lu, D, Sherry, AD, and Newgard, CB. "Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets." The Journal of Biological Chemistry 283, no. 43 (October 2008): 28909-28917.  Full Text
    • Fueger, PT, Schisler, JC, Lu, D, Babu, DA, Mirmira, RG, Newgard, CB, and Hohmeier, HE. "Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function." Mol Endocrinol 22, no. 5 (May 2008): 1251-1259.  Full Text  Link to Item
    • Schisler, JC, Fueger, PT, Babu, DA, Hohmeier, HE, Tessem, JS, Lu, D, Becker, TC, Naziruddin, B, Levy, M, Mirmira, RG, and Newgard, CB. "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." Molecular and Cellular Biology 28, no. 10 (May 2008): 3465-3476.  Full Text
    • Hardy, OT, Hohmeier, HE, Becker, TC, Manduchi, E, Doliba, NM, Gupta, RK, White, P, Stoeckert, CJ, Matschinsky, FM, Newgard, CB, and Kaestner, KH. "Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents." Molecular Endocrinology (Baltimore, Md.) 21, no. 3 (March 2007): 765-773.  Full Text
    • Chen, S, Ding, J-H, Bekeredjian, R, Yang, B-Z, Shohet, RV, Johnston, SA, Hohmeier, HE, Newgard, CB, and Grayburn, PA. "Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology." Proc Natl Acad Sci U S A 103, no. 22 (May 30, 2006): 8469-8474.  Full Text  Link to Item
    • Collier, JJ, Fueger, PT, Hohmeier, HE, and Newgard, CB. "Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines." Diabetes 55, no. 5 (May 2006): 1398-1406.  Full Text
    • Hohmeier, HE, and Newgard, CB. "Islets for all?." Nature Biotechnology 23, no. 10 (October 2005): 1231-1232.  Full Text
    • Hohmeier, HE, and Newgard, CB. "Cell lines derived from pancreatic islets." Mol Cell Endocrinol 228, no. 1-2 (December 30, 2004): 121-128. (Review)  Full Text  Link to Item
    • Newgard, CB, Hohmeier, HE, Lu, D, Jensen, MV, Tran, VV, Chen, G, Burgess, S, and Sherry, AD. "Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies." Cell Biochemistry and Biophysics 40, no. 3 Suppl (January 2004): 159-168. (Review)  Full Text
    • Yang, S, Fransson, U, Fagerhus, L, Holst, LS, Hohmeier, HE, Renström, E, and Mulder, H. "Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing β-cell line (INS-1 832/13)." Molecular Endocrinology 18, no. 9 (2004): 2312-2320.  Full Text
    • Hohmeier, HE, Tran, VV, Chen, G, Gasa, R, and Newgard, CB. "Inflammatory mechanisms in diabetes: lessons from the beta-cell." Int J Obes Relat Metab Disord 27 Suppl 3 (December 2003): S12-S16. (Review)  Full Text  Link to Item
    • Tran, VV, Chen, G, Newgard, CB, and Hohmeier, HE. "Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy." Diabetes 52, no. 6 (June 2003): 1423-1432.  Link to Item
    • Chen, G, Hohmeier, HE, and Newgard, CB. "Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines." J Biol Chem 276, no. 1 (January 5, 2001): 766-772.  Full Text  Link to Item
    • Chen, G, Hohmeier, HE, Gasa, R, Tran, VV, and Newgard, CB. "Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity." Diabetes 49, no. 4 (April 2000): 562-570.  Link to Item
    • Hohmeier, HE, Mulder, H, Chen, G, Henkel-Rieger, R, Prentki, M, and Newgard, CB. "Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion." Diabetes 49, no. 3 (March 2000): 424-430.  Full Text
    • Hohmeier, HE, Thigpen, A, Tran, VV, Davis, R, and Newgard, CB. "Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production." J Clin Invest 101, no. 9 (May 1, 1998): 1811-1820.  Full Text  Link to Item
    • Newgard, CB, Clark, S, BeltrandelRio, H, Hohmeier, HE, Quaade, C, and Normington, K. "Engineered cell lines for insulin replacement in diabetes: current status and future prospects." Diabetologia 40 Suppl 2 (July 1997): S42-S47. (Review)  Link to Item
    • Hohmeier, HE, BeltrandelRio, H, Clark, SA, Henkel-Rieger, R, Normington, K, and Newgard, CB. "Regulation of insulin secretion from novel engineered insulinoma cell lines." Diabetes 46, no. 6 (June 1997): 968-977.  Full Text
    • Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulin secretory cells for the therapy of diabetes mellitus." Naturwissenschaften 83, no. 1 (February 7, 1996): 1-5. (Review)  Full Text
    • Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulin secretory cells for the therapy of diabetes mellitus." Naturwissenschaften 83, no. 1 (1996): 1-5.  Full Text
    • Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulinsezernierende Zellen zur Therapie des Diabetes mellitus." Naturwissenschaften 83, no. 1 (1996): 1-5.
    • König, U, Götz, H, Babel, D, Hohmeier, HE, Thinnes, FP, and Hilschmann, N. "Studies on human porin. V. The expression of “Porin 31H L” in the plasmalemm is not caused by cell transformation." Biological Chemistry Hoppe-Seyler 372, no. 2 (January 1, 1991): 565-572.  Full Text
    • König, U, Götz, H, Walter, G, Babel, D, Hohmeier, HE, Thinnes, FP, and Hilschmann, N. "Studies on human porin. V. The expression of "porin31HL" in the plasmalemma is not by cell transformation." Biological Chemistry Hoppe-Seyler 372, no. 8 (1991): 565-572.

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