Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Biochemistry, UT Southwestern Medical School 1995 - 1997
  • Postdoctoral Fellow, Immunology, UT Southwestern Medical School 1991 - 1995
  • Ph.D., Georg August Universitat Gottingen (Germany) 1992
  • M.D., University of Hannover (Germany) 1986
• 

  Previous Appointments & Affiliations

  • Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2017 - 2020
  • Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006 - 2017
  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
• Research
• 

  Selected Grants

  • Development of small molecules for islet beta-cell regeneration and diabetes therapy awarded by University of Michigan 2019 - 2023
  • Small molecules with pleiotropic positive effects on beta-cell health awarded by Eli Lilly and Company 2019 - 2022
  • Pilot Study: Testing of Comprehensive Mitochondrial Profiling Platform in Islet cells awarded by Eli Lilly and Company 2020 - 2022
  • Biochemical Consequences of Cdka I I Mutation that Result in Unprocessed, Nonfunctional Insulin and Type 2 Diabetes awarded by Department of Defense 2016 - 2021
  • Networks of nutritional stress in human pancreatic islet cells awarded by Merck Sharp & Dohme 2018 - 2020
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2020
  • Biochemical Mechanisms of NNMT Inhibitors awarded by Eli Lilly and Company 2017 - 2018
  • HIRN UCSD awarded by University of California - San Diego 2017 - 2018
  • Physiology of SC-derived Human Beta Cells awarded by  Harvard University 2016 - 2017
  • Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication awarded by Mount Sinai School of Medicine 2013 - 2015
  • Engineering of Immunoprotection in B-Cell Lines awarded by National Institutes of Health 2002 - 2007
• 

  External Relationships

  • Diabetologia
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hohmeier, Hans E., Lu Zhang, Brandon Taylor, Samuel Stephens, Danhong Lu, Peter McNamara, Bryan Laffitte, and Christopher B. Newgard. “Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.” Plos One 15, no. 3 (2020): e0224344. https://doi.org/10.1371/journal.pone.0224344.
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    • Hohmeier, Hans E., Jie An, and Christopher B. Newgard. “Improving human β-cell maturation in vitro.” Nat Cell Biol 21, no. 2 (February 2019): 119–21. https://doi.org/10.1038/s41556-019-0277-6.
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    • Hayes, Heather L., Brett S. Peterson, Jonathan M. Haldeman, Christopher B. Newgard, Hans E. Hohmeier, and Samuel B. Stephens. “Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.” Plos One 12, no. 2 (2017): e0172567. https://doi.org/10.1371/journal.pone.0172567.
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    • Hayes, Heather L., Lu Zhang, Thomas C. Becker, Jonathan M. Haldeman, Samuel B. Stephens, Michelle Arlotto, Larry G. Moss, Christopher B. Newgard, and Hans E. Hohmeier. “A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.” Mol Cell Biol 36, no. 23 (December 1, 2016): 2918–30. https://doi.org/10.1128/MCB.00103-16.
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    • Shang, Jin, Jing Li, Mark P. Keller, Hans E. Hohmeier, Yong Wang, Yue Feng, Heather H. Zhou, et al. “Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.” Mol Endocrinol 29, no. 9 (September 2015): 1243–53. https://doi.org/10.1210/me.2014-1335.
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    • Lorenzo, Damaris N., Jane A. Healy, Janell Hostettler, Jonathan Davis, Jiayu Yang, Chao Wang, Hans Ewald Hohmeier, Mingjie Zhang, and Vann Bennett. “Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.” J Clin Invest 125, no. 8 (August 3, 2015): 3087–3102. https://doi.org/10.1172/JCI81317.
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    • Tessem, Jeffery S., Larry G. Moss, Lily C. Chao, Michelle Arlotto, Danhong Lu, Mette V. Jensen, Samuel B. Stephens, Peter Tontonoz, Hans E. Hohmeier, and Christopher B. Newgard. “Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.” Proc Natl Acad Sci U S A 111, no. 14 (April 8, 2014): 5242–47. https://doi.org/10.1073/pnas.1320953111.
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    • Hayes, Heather L., Larry G. Moss, Jonathan C. Schisler, Jonathan M. Haldeman, Zhushan Zhang, Paul B. Rosenberg, Christopher B. Newgard, and Hans E. Hohmeier. “Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.” Mol Cell Biol 33, no. 20 (October 2013): 4017–29. https://doi.org/10.1128/MCB.00469-13.
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    • Jensen, Mette V., Jonathan M. Haldeman, Hengtao Zhang, Danhong Lu, Mark O. Huising, Wylie W. Vale, Hans E. Hohmeier, Paul Rosenberg, and Christopher B. Newgard. “Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.” J Biol Chem 288, no. 32 (August 9, 2013): 23128–40. https://doi.org/10.1074/jbc.M113.491654.
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    • Li, Xiaoyan Nina, James Herrington, Aleksandr Petrov, Lan Ge, George Eiermann, Yusheng Xiong, Mette V. Jensen, et al. “The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.” J Pharmacol Exp Ther 344, no. 2 (February 2013): 407–16. https://doi.org/10.1124/jpet.112.199083.
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    • Stephens, Samuel B., Jonathan C. Schisler, Hans E. Hohmeier, Jie An, Albert Y. Sun, Geoffrey S. Pitt, and Christopher B. Newgard. “A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.” Cell Metab 16, no. 1 (July 3, 2012): 33–43. https://doi.org/10.1016/j.cmet.2012.05.011.
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    • Lemaire, Katleen, Rodrigo F. Moura, Mikaela Granvik, Mariana Igoillo-Esteve, Hans E. Hohmeier, Nico Hendrickx, Christopher B. Newgard, Etienne Waelkens, Miriam Cnop, and Frans Schuit. “Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.” Plos One 6, no. 4 (April 6, 2011): e18517. https://doi.org/10.1371/journal.pone.0018517.
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    • Healy, Jane A., Kent R. Nilsson, Hans E. Hohmeier, Jelena Berglund, Jonathan Davis, Janis Hoffman, Martin Kohler, et al. “Cholinergic augmentation of insulin release requires ankyrin-B.” Sci Signal 3, no. 113 (March 16, 2010): ra19. https://doi.org/10.1126/scisignal.2000771.
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    • Malakauskas, Sandra M., Wissam M. Kourany, Xiao Yin Zhang, Danhong Lu, Robert D. Stevens, Timothy R. Koves, Hans E. Hohmeier, Deborah M. Muoio, Christopher B. Newgard, and Thu H. Le. “Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.” Mol Endocrinol 23, no. 6 (June 2009): 881–92. https://doi.org/10.1210/me.2008-0274.
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    • Schnedl, Wolfgang J., Claudia Piswanger-Soelkner, Sandra J. Wallner, Pia Reittner, Robert Krause, Rainer W. Lipp, and Hans E. Hohmeier. “Agenesis of the dorsal pancreas and associated diseases.” Dig Dis Sci 54, no. 3 (March 2009): 481–87. https://doi.org/10.1007/s10620-008-0370-3.
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    • Ronnebaum, Sarah M., Mette V. Jensen, Hans E. Hohmeier, Shawn C. Burgess, Yun-Ping Zhou, Su Qian, Douglas MacNeil, et al. “Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.” J Biol Chem 283, no. 43 (October 24, 2008): 28909–17. https://doi.org/10.1074/jbc.M804665200.
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    • Fueger, Patrick T., Jonathan C. Schisler, Danhong Lu, Daniella A. Babu, Raghavendra G. Mirmira, Christopher B. Newgard, and Hans E. Hohmeier. “Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.” Mol Endocrinol 22, no. 5 (May 2008): 1251–59. https://doi.org/10.1210/me.2007-0500.
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    • Schisler, Jonathan C., Patrick T. Fueger, Daniella A. Babu, Hans E. Hohmeier, Jeffery S. Tessem, Danhong Lu, Thomas C. Becker, et al. “Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.” Mol Cell Biol 28, no. 10 (May 2008): 3465–76. https://doi.org/10.1128/MCB.01791-07.
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    • Hardy, Olga T., Hans E. Hohmeier, Thomas C. Becker, Elisabetta Manduchi, Nicolai M. Doliba, Rana K. Gupta, Peter White, et al. “Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.” Mol Endocrinol 21, no. 3 (March 2007): 765–73. https://doi.org/10.1210/me.2006-0411.
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    • Chen, Shuyuan, Jia-huan Ding, Raffi Bekeredjian, Bing-zhi Yang, Ralph V. Shohet, Stephen A. Johnston, Hans E. Hohmeier, Christopher B. Newgard, and Paul A. Grayburn. “Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.” Proc Natl Acad Sci U S A 103, no. 22 (May 30, 2006): 8469–74. https://doi.org/10.1073/pnas.0602921103.
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    • Collier, J Jason, Patrick T. Fueger, Hans E. Hohmeier, and Christopher B. Newgard. “Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.” Diabetes 55, no. 5 (May 2006): 1398–1406. https://doi.org/10.2337/db05-1000.
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    • Hohmeier, Hans E., and Christopher B. Newgard. “Islets for all?” Nat Biotechnol 23, no. 10 (October 2005): 1231–32. https://doi.org/10.1038/nbt1005-1231.
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    • Hohmeier, Hans E., and Christopher B. Newgard. “Cell lines derived from pancreatic islets.” Mol Cell Endocrinol 228, no. 1–2 (December 30, 2004): 121–28. https://doi.org/10.1016/j.mce.2004.04.017.
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    • Yang, Shumin, Ulrika Fransson, Lillian Fagerhus, Lena Stenson Holst, Hans E. Hohmeier, Erik Renström, and Hindrik Mulder. “Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).” Mol Endocrinol 18, no. 9 (September 2004): 2312–20. https://doi.org/10.1210/me.2004-0148.
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    • Newgard, Christopher B., Hans E. Hohmeier, Danhong Lu, Mette Valentin Jensen, Veronique V. Tran, Guoxun Chen, Shawn Burgess, and A Dean Sherry. “Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.” Cell Biochem Biophys 40, no. 3 Suppl (2004): 159–68. https://doi.org/10.1385/cbb:40:3:159.
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    • Hohmeier, H. E., V. V. Tran, G. Chen, R. Gasa, and C. B. Newgard. “Inflammatory mechanisms in diabetes: lessons from the beta-cell.” Int J Obes Relat Metab Disord 27 Suppl 3 (December 2003): S12–16. https://doi.org/10.1038/sj.ijo.0802493.
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    • Tran, Veronique Vien, Guoxun Chen, Christopher B. Newgard, and Hans E. Hohmeier. “Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy.” Diabetes 52, no. 6 (June 2003): 1423–32. https://doi.org/10.2337/diabetes.52.6.1423.
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    • Chen, G., H. E. Hohmeier, and C. B. Newgard. “Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines.” J Biol Chem 276, no. 1 (January 5, 2001): 766–72. https://doi.org/10.1074/jbc.M008330200.
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    • Chen, G., H. E. Hohmeier, R. Gasa, V. V. Tran, and C. B. Newgard. “Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.” Diabetes 49, no. 4 (April 2000): 562–70. https://doi.org/10.2337/diabetes.49.4.562.
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    • Hohmeier, H. E., H. Mulder, G. Chen, R. Henkel-Rieger, M. Prentki, and C. B. Newgard. “Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.” Diabetes 49, no. 3 (March 2000): 424–30. https://doi.org/10.2337/diabetes.49.3.424.
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    • Hohmeier, H. E., A. Thigpen, V. V. Tran, R. Davis, and C. B. Newgard. “Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production.” J Clin Invest 101, no. 9 (May 1, 1998): 1811–20. https://doi.org/10.1172/JCI1489.
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    • Newgard, C. B., S. Clark, H. BeltrandelRio, H. E. Hohmeier, C. Quaade, and K. Normington. “Engineered cell lines for insulin replacement in diabetes: current status and future prospects.” Diabetologia 40 Suppl 2 (July 1997): S42–47. https://doi.org/10.1007/s001250051398.
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    • Hohmeier, H. E., H. BeltrandelRio, S. A. Clark, R. Henkel-Rieger, K. Normington, and C. B. Newgard. “Regulation of insulin secretion from novel engineered insulinoma cell lines.” Diabetes 46, no. 6 (June 1997): 968–77. https://doi.org/10.2337/diab.46.6.968.
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    • Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “Insulinsezernierende Zellen zur Therapie des Diabetes mellitus.” Naturwissenschaften 83, no. 1 (December 1, 1996): 1–5.
    • Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “[Insulin producing cells as therapy in diabetes mellitus].” Naturwissenschaften 83, no. 1 (January 1996): 1–5.
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    • König, U., H. Götz, G. Walter, D. Babel, H. E. Hohmeier, F. P. Thinnes, and N. Hilschmann. “[Studies on human porin. V. The expression of "porin31HL" in the plasmalemma is not by cell transformation].” Biol Chem Hoppe Seyler 372, no. 8 (August 1991): 565–72.
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    • König, U., H. Götz, G. Walter, D. Babel, H. E. Hohmeier, F. P. Thinnes, and N. Hilschmann. “Studies on human porin. V. The expression of "porin31HL" in the plasmalemma is not by cell transformation.” Biological Chemistry Hoppe Seyler 372, no. 8 (1991): 565–72.

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