Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Biochemistry, UT Southwestern Medical School 1995 - 1997
  • Postdoctoral Fellow, Immunology, UT Southwestern Medical School 1991 - 1995
  • Ph.D., Georg August Universitat Gottingen (Germany) 1992
  • M.D., University of Hannover (Germany) 1986
• 

  Duke Appointment History

  • Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006 - 2017
  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
• Research
• 

  Selected Grants

  • Networks of nutritional stress in human pancreatic islet cells awarded by Merck Sharp & Dohme 2018 - 2019
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2019
  • Biochemical Mechanisms of NNMT Inhibitors awarded by Eli Lilly and Company 2017 - 2018
  • HIRN UCSD awarded by University of California - San Diego 2017 - 2018
  • Physiology of SC-derived Human Beta Cells awarded by  Harvard University 2016 - 2017
  • Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication awarded by Mount Sinai School of Medicine 2013 - 2015
  • Engineering of Immunoprotection in B-Cell Lines awarded by National Institutes of Health 2002 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hohmeier, HE, An, J, and Newgard, CB. "Improving human β-cell maturation in vitro." Nature Cell Biology 21, no. 2 (February 2019): 119-121.  Full Text
    • Hayes, HL, Peterson, BS, Haldeman, JM, Newgard, CB, Hohmeier, HE, and Stephens, SB. "Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival." Plos One 12, no. 2 (January 2017): e0172567-null.  Full Text
    • Hayes, HL, Zhang, L, Becker, TC, Haldeman, JM, Stephens, SB, Arlotto, M, Moss, LG, Newgard, CB, and Hohmeier, HE. "A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation." Molecular and Cellular Biology 36, no. 23 (December 2016): 2918-2930.  Full Text
    • Shang, J, Li, J, Keller, MP, Hohmeier, HE, Wang, Y, Feng, Y, Zhou, HH, Shen, X, Rabaglia, M, Soni, M, Attie, AD, Newgard, CB, Thornberry, NA, Howard, AD, and Zhou, Y-P. "Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells." Molecular Endocrinology (Baltimore, Md.) 29, no. 9 (September 2015): 1243-1253.  Full Text
    • Lorenzo, DN, Healy, JA, Hostettler, J, Davis, J, Yang, J, Wang, C, Hohmeier, HE, Zhang, M, and Bennett, V. "Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency." The Journal of Clinical Investigation 125, no. 8 (August 2015): 3087-3102.  Full Text
    • Tessem, JS, Moss, LG, Chao, LC, Arlotto, M, Lu, D, Jensen, MV, Stephens, SB, Tontonoz, P, Hohmeier, HE, and Newgard, CB. "Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors." Proceedings of the National Academy of Sciences of the United States of America 111, no. 14 (April 2014): 5242-5247.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 Activates Islet  - and  -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 15, 2013): 4017-4029.  Full Text
    • Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 2013): 4017-4029.  Full Text
    • Jensen, MV, Haldeman, JM, Zhang, H, Lu, D, Huising, MO, Vale, WW, Hohmeier, HE, Rosenberg, P, and Newgard, CB. "Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 288, no. 32 (August 2013): 23128-23140.  Full Text
    • Li, XN, Herrington, J, Petrov, A, Ge, L, Eiermann, G, Xiong, Y, Jensen, MV, Hohmeier, HE, Newgard, CB, Garcia, ML, Wagner, M, Zhang, BB, Thornberry, NA, Howard, AD, Kaczorowski, GJ, and Zhou, Y-P. "The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets." The Journal of Pharmacology and Experimental Therapeutics 344, no. 2 (February 2013): 407-416.  Full Text
    • Stephens, SB, Schisler, JC, Hohmeier, HE, An, J, Sun, AY, Pitt, GS, and Newgard, CB. "A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function." Cell Metabolism 16, no. 1 (July 2012): 33-43.  Full Text
    • Lemaire, K, Moura, RF, Granvik, M, Igoillo-Esteve, M, Hohmeier, HE, Hendrickx, N, Newgard, CB, Waelkens, E, Cnop, M, and Schuit, F. "Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis." Plos One 6, no. 4 (April 6, 2011): e18517-null.  Full Text
    • Healy, JA, Nilsson, KR, Hohmeier, HE, Berglund, J, Davis, J, Hoffman, J, Kohler, M, Li, L-S, Berggren, P-O, Newgard, CB, and Bennett, V. "Cholinergic augmentation of insulin release requires ankyrin-B." Science Signaling 3, no. 113 (March 16, 2010): ra19-null.  Full Text
    • Malakauskas, SM, Kourany, WM, Zhang, XY, Lu, D, Stevens, RD, Koves, TR, Hohmeier, HE, Muoio, DM, Newgard, CB, and Le, TH. "Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha." Molecular Endocrinology (Baltimore, Md.) 23, no. 6 (June 2009): 881-892.  Full Text
    • Schnedl, WJ, Piswanger-Soelkner, C, Wallner, SJ, Reittner, P, Krause, R, Lipp, RW, and Hohmeier, HE. "Agenesis of the dorsal pancreas and associated diseases." Digestive Diseases and Sciences 54, no. 3 (2009): 481-487.  Full Text
    • Ronnebaum, SM, Jensen, MV, Hohmeier, HE, Burgess, SC, Zhou, Y-P, Qian, S, MacNeil, D, Howard, A, Thornberry, N, Ilkayeva, O, Lu, D, Sherry, AD, and Newgard, CB. "Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets." The Journal of Biological Chemistry 283, no. 43 (October 2008): 28909-28917.  Full Text
    • Fueger, PT, Schisler, JC, Lu, D, Babu, DA, Mirmira, RG, Newgard, CB, and Hohmeier, HE. "Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function." Mol Endocrinol 22, no. 5 (May 2008): 1251-1259.  Full Text  Link to Item
    • Schisler, JC, Fueger, PT, Babu, DA, Hohmeier, HE, Tessem, JS, Lu, D, Becker, TC, Naziruddin, B, Levy, M, Mirmira, RG, and Newgard, CB. "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." Molecular and Cellular Biology 28, no. 10 (May 2008): 3465-3476.  Full Text
    • Hardy, OT, Hohmeier, HE, Becker, TC, Manduchi, E, Doliba, NM, Gupta, RK, White, P, Stoeckert, CJ, Matschinsky, FM, Newgard, CB, and Kaestner, KH. "Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents." Molecular Endocrinology (Baltimore, Md.) 21, no. 3 (March 2007): 765-773.  Full Text
    • Chen, S, Ding, J-H, Bekeredjian, R, Yang, B-Z, Shohet, RV, Johnston, SA, Hohmeier, HE, Newgard, CB, and Grayburn, PA. "Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology." Proceedings of the National Academy of Sciences of the United States of America 103, no. 22 (May 18, 2006): 8469-8474.  Full Text
    • Collier, JJ, Fueger, PT, Hohmeier, HE, and Newgard, CB. "Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines." Diabetes 55, no. 5 (May 2006): 1398-1406.  Full Text
    • Hohmeier, HE, and Newgard, CB. "Islets for all?." Nature Biotechnology 23, no. 10 (October 2005): 1231-1232.  Full Text
    • Hohmeier, HE, and Newgard, CB. "Cell lines derived from pancreatic islets." Mol Cell Endocrinol 228, no. 1-2 (December 30, 2004): 121-128. (Review)  Full Text  Link to Item
    • Yang, S, Fransson, U, Fagerhus, L, Holst, LS, Hohmeier, HE, Renström, E, and Mulder, H. "Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13)." Molecular Endocrinology (Baltimore, Md.) 18, no. 9 (September 2004): 2312-2320.  Full Text
    • Newgard, CB, Hohmeier, HE, Lu, D, Jensen, MV, Tran, VV, Chen, G, Burgess, S, and Sherry, AD. "Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies." Cell Biochemistry and Biophysics 40, no. 3 Suppl (January 2004): 159-168. (Review)  Full Text
    • Hohmeier, HE, Tran, VV, Chen, G, Gasa, R, and Newgard, CB. "Inflammatory mechanisms in diabetes: lessons from the beta-cell." Int J Obes Relat Metab Disord 27 Suppl 3 (December 2003): S12-S16. (Review)  Full Text  Link to Item
    • Tran, VV, Chen, G, Newgard, CB, and Hohmeier, HE. "Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy." Diabetes 52, no. 6 (June 2003): 1423-1432.  Link to Item
    • Chen, G, Hohmeier, HE, and Newgard, CB. "Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines." The Journal of Biological Chemistry 276, no. 1 (January 2001): 766-772.  Full Text
    • Chen, G, Hohmeier, HE, Gasa, R, Tran, VV, and Newgard, CB. "Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity." Diabetes 49, no. 4 (April 2000): 562-570.  Link to Item
    • Hohmeier, HE, Mulder, H, Chen, G, Henkel-Rieger, R, Prentki, M, and Newgard, CB. "Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion." Diabetes 49, no. 3 (March 2000): 424-430.  Full Text
    • Hohmeier, HE, Thigpen, A, Tran, VV, Davis, R, and Newgard, CB. "Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production." J Clin Invest 101, no. 9 (May 1, 1998): 1811-1820.  Full Text  Link to Item
    • Newgard, CB, Clark, S, BeltrandelRio, H, Hohmeier, HE, Quaade, C, and Normington, K. "Engineered cell lines for insulin replacement in diabetes: current status and future prospects." Diabetologia 40 Suppl 2 (July 1997): S42-S47. (Review)  Full Text
    • Hohmeier, HE, BeltrandelRio, H, Clark, SA, Henkel-Rieger, R, Normington, K, and Newgard, CB. "Regulation of insulin secretion from novel engineered insulinoma cell lines." Diabetes 46, no. 6 (June 1997): 968-977.  Full Text
    • Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulin secretory cells for the therapy of diabetes mellitus." Naturwissenschaften 83, no. 1 (1996): 1-5.  Full Text
    • Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulinsezernierende Zellen zur Therapie des Diabetes mellitus." Naturwissenschaften 83, no. 1 (January 1996): 1-5.  Full Text
    • Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulinsezernierende Zellen zur Therapie des Diabetes mellitus." Naturwissenschaften 83, no. 1 (January 1, 1996): 1-5.  Full Text
    • König, U, Götz, H, Babel, D, Hohmeier, HE, Thinnes, FP, and Hilschmann, N. "Studies on human porin. V. The expression of “Porin 31H L” in the plasmalemm is not caused by cell transformation." Biological Chemistry Hoppe-Seyler 372, no. 2 (January 1, 1991): 565-572.  Full Text
    • König, U, Götz, H, Walter, G, Babel, D, Hohmeier, HE, Thinnes, FP, and Hilschmann, N. "Studies on human porin. V. The expression of "porin31HL" in the plasmalemma is not by cell transformation." Biological Chemistry Hoppe-Seyler 372, no. 8 (1991): 565-572.

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