Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.

Published

Journal Article

3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.

Full Text

Duke Authors

Cited Authors

  • Smith, MS; Kessler, JA; Rankin, CD; Pagano, JS; Kurtzberg, J; Carter, SG

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 144 - 147

PubMed ID

  • 8431013

Pubmed Central ID

  • 8431013

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/aac.37.1.144

Language

  • eng