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Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.

Publication ,  Journal Article
Smith, MS; Kessler, JA; Rankin, CD; Pagano, JS; Kurtzberg, J; Carter, SG
Published in: Antimicrob Agents Chemother
January 1993

3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.

Duke Scholars

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

January 1993

Volume

37

Issue

1

Start / End Page

144 / 147

Location

United States

Related Subject Headings

  • Zidovudine
  • Virus Replication
  • Viral Plaque Assay
  • Microbiology
  • Humans
  • HIV-1
  • Drug Synergism
  • Dideoxynucleosides
  • Cell Line
  • Antiviral Agents
 

Citation

APA
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ICMJE
MLA
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Smith, M. S., Kessler, J. A., Rankin, C. D., Pagano, J. S., Kurtzberg, J., & Carter, S. G. (1993). Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1. Antimicrob Agents Chemother, 37(1), 144–147. https://doi.org/10.1128/AAC.37.1.144
Smith, M. S., J. A. Kessler, C. D. Rankin, J. S. Pagano, J. Kurtzberg, and S. G. Carter. “Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.Antimicrob Agents Chemother 37, no. 1 (January 1993): 144–47. https://doi.org/10.1128/AAC.37.1.144.
Smith MS, Kessler JA, Rankin CD, Pagano JS, Kurtzberg J, Carter SG. Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1993 Jan;37(1):144–7.
Smith, M. S., et al. “Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.Antimicrob Agents Chemother, vol. 37, no. 1, Jan. 1993, pp. 144–47. Pubmed, doi:10.1128/AAC.37.1.144.
Smith MS, Kessler JA, Rankin CD, Pagano JS, Kurtzberg J, Carter SG. Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1993 Jan;37(1):144–147.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

January 1993

Volume

37

Issue

1

Start / End Page

144 / 147

Location

United States

Related Subject Headings

  • Zidovudine
  • Virus Replication
  • Viral Plaque Assay
  • Microbiology
  • Humans
  • HIV-1
  • Drug Synergism
  • Dideoxynucleosides
  • Cell Line
  • Antiviral Agents