Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp

Journal Article (Journal Article)

A novel platelet activating factor (PAF) antagonist, Sch 47918, was isolated from the fermentation broth of the fungus, Phoma sp. The structure of this compound was elucidated by spectroscopic methods. The proposed structure and stereochemistry of Sch 47918 were confirmed by single-crystal X-ray diffraction analysis. Sch 47918 was found to be active at IC50 = 6.96 μM in the in vitro PAF-induced human platelet aggregation assay. © 1992, American Chemical Society. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Chu, M; Patel, MG; Gullo, VP; Truumees, I; Paur, MS; Mcphail, AT

Published Date

  • October 1, 1992

Published In

Volume / Issue

  • 57 / 22

Start / End Page

  • 5817 - 5818

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo00048a008

Citation Source

  • Scopus