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Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp

Publication ,  Journal Article
Chu, M; Patel, MG; Gullo, VP; Truumees, I; Paur, MS; Mcphail, AT
Published in: Journal of Organic Chemistry
October 1, 1992

A novel platelet activating factor (PAF) antagonist, Sch 47918, was isolated from the fermentation broth of the fungus, Phoma sp. The structure of this compound was elucidated by spectroscopic methods. The proposed structure and stereochemistry of Sch 47918 were confirmed by single-crystal X-ray diffraction analysis. Sch 47918 was found to be active at IC50 = 6.96 μM in the in vitro PAF-induced human platelet aggregation assay. © 1992, American Chemical Society. All rights reserved.

Duke Scholars

Published In

Journal of Organic Chemistry

DOI

EISSN

1520-6904

ISSN

0022-3263

Publication Date

October 1, 1992

Volume

57

Issue

22

Start / End Page

5817 / 5818

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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MLA
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Chu, M., Patel, M. G., Gullo, V. P., Truumees, I., Paur, M. S., & Mcphail, A. T. (1992). Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp. Journal of Organic Chemistry, 57(22), 5817–5818. https://doi.org/10.1021/jo00048a008
Chu, M., M. G. Patel, V. P. Gullo, I. Truumees, M. S. Paur, and A. T. Mcphail. “Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp.” Journal of Organic Chemistry 57, no. 22 (October 1, 1992): 5817–18. https://doi.org/10.1021/jo00048a008.
Chu M, Patel MG, Gullo VP, Truumees I, Paur MS, Mcphail AT. Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp. Journal of Organic Chemistry. 1992 Oct 1;57(22):5817–8.
Chu, M., et al. “Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp.” Journal of Organic Chemistry, vol. 57, no. 22, Oct. 1992, pp. 5817–18. Scopus, doi:10.1021/jo00048a008.
Chu M, Patel MG, Gullo VP, Truumees I, Paur MS, Mcphail AT. Sch 47918: A Novel PAF Antagonist from the Fungus Phoma Sp. Journal of Organic Chemistry. 1992 Oct 1;57(22):5817–5818.
Journal cover image

Published In

Journal of Organic Chemistry

DOI

EISSN

1520-6904

ISSN

0022-3263

Publication Date

October 1, 1992

Volume

57

Issue

22

Start / End Page

5817 / 5818

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry