Connections and regulation of the human estrogen receptor.

Journal Article (Review)

Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. Recent progress in the study of the molecular mechanism of action of estrogen(s) has revealed why different cells can respond to the same hormone in a different manner. Three of these findings are of particular importance: (i) There are two genetically and functionally distinct estrogen receptors that have distinct expression patterns in vivo; (ii) the positive and negative transcriptional activities of these receptors require them to engage transcription cofactors (coactivators or corepressors) in target cells; and (iii) not all cofactors are functionally equivalent, nor are they expressed in the same manner in all cells. Thus, although the estrogen receptor is required for a cell to respond to an estrogenic stimulus, the nature and extent of that response are determined by the proteins, pathways, and processes with which the receptor interacts.

Full Text

Duke Authors

Cited Authors

  • McDonnell, DP; Norris, JD

Published Date

  • May 31, 2002

Published In

Volume / Issue

  • 296 / 5573

Start / End Page

  • 1642 - 1644

PubMed ID

  • 12040178

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1071884

Language

  • eng

Conference Location

  • United States