Connections and regulation of the human estrogen receptor.
Journal Article (Journal Article;Review)
Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. Recent progress in the study of the molecular mechanism of action of estrogen(s) has revealed why different cells can respond to the same hormone in a different manner. Three of these findings are of particular importance: (i) There are two genetically and functionally distinct estrogen receptors that have distinct expression patterns in vivo; (ii) the positive and negative transcriptional activities of these receptors require them to engage transcription cofactors (coactivators or corepressors) in target cells; and (iii) not all cofactors are functionally equivalent, nor are they expressed in the same manner in all cells. Thus, although the estrogen receptor is required for a cell to respond to an estrogenic stimulus, the nature and extent of that response are determined by the proteins, pathways, and processes with which the receptor interacts.
- McDonnell, DP; Norris, JD
- May 31, 2002
Volume / Issue
- 296 / 5573
Start / End Page
- 1642 - 1644
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States