Donald Patrick McDonnell
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine
The research in our group is focused on the development and application of mechanism based approaches to identify novel therapeutics for use in the treatment and prevention of hormonally responsive cancers. Specifically we are interested in the pharmaceutical exploitation of the estrogen and androgen receptors as therapeutic targets in breast and prostate cancers and in defining how these receptors influence the pathogenesis of these diseases. These efforts have led to the discovery of several drugs that are currently being evaluated in the clinic as cancer therapeutics, and to the identification of potential biomarkers and predictors of response that can help to target the use of these new drugs. Most recently we have explored approaches to treat triple negative breast cancer and have identified an important pathway that links obesity/dyslipidemia and cancer risk.
Current Appointments & Affiliations
- Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2002
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2000
- Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1994
Contact Information
- C238a Lev Sci Res Ctr, Durham, NC 27708
- Duke Box 3813, Durham, NC 27710
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donald.mcdonnell@duke.edu
(919) 684-6035
- Background
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Education, Training, & Certifications
- Ph.D., Baylor College of Medicine 1988
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Previous Appointments & Affiliations
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018 - 2021
- Chair, Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011 - 2020
- Associate Professor of Pharmacology & Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 1997 - 2000
- Associate Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 1997
- Recognition
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In the News
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MAR 17, 2022 Duke Cancer Institute -
OCT 13, 2021 Duke Health News -
AUG 26, 2021 Duke Health News -
OCT 22, 2019 Duke Health News -
JUN 18, 2019 Duke Health News -
MAY 3, 2018 Duke Magazine -
FEB 21, 2017 Duke Health News -
OCT 15, 2014 Duke Today -
OCT 15, 2014 -
DEC 3, 2013 -
DEC 3, 2013 Duke Today -
DEC 2, 2013 BBC News -
DEC 2, 2013 The News & Observer -
DEC 2, 2013 -
DEC 2, 2013 Duke Today -
AUG 1, 2013 WRAL.com -
JUN 28, 2013 Fox News -
JUN 18, 2013 -
JUN 17, 2013 London Daily Express
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Awards & Honors
- Robert R. Ruffolo Career Achievement Award in Pharmacology. ASPET. 2017
- Member. National Academy of Medicine. 2016
- Distinguished Alumni Award. Baylor College of Medicine. 2013
- Roy O. Greep Award. The Endocrine Society. 2013
- AAAS Fellows. American Association for the Advancement of Science, The. 2011
- MERIT Award. National Institutes of Health. 2005
- Expertise
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Subject Headings
- 3T3 Cells
- 8-Bromo Cyclic Adenosine Monophosphate
- ADP-ribosyl Cyclase 1
- Acetates
- Acetyl Coenzyme A
- Acetyltransferases
- Adolescent
- Adult
- Age Factors
- Aging
- Aldehyde Dehydrogenase
- Allosteric Regulation
- Amino Acid Motifs
- Amino Acid Sequence
- Androgen Receptor Antagonists
- Androgens
- Antigens, CD
- Antigens, Nuclear
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Apoptosis
- Aromatase
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Atlases as Topic
- Autocrine Communication
- Benzhydryl Compounds
- Benzoates
- Binding Sites
- Biological Transport
- Biomimetic Materials
- Blotting, Western
- Bone and Bones
- Breast
- Breast Neoplasms
- Bruch Membrane
- COS Cells
- Cadherins
- Calcium
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Carcinoma, Hepatocellular
- Cardiovascular System
- Cell Line, Tumor
- Cell Nucleus
- Cell Proliferation
- Cercopithecus aethiops
- Chemokine CXCL12
- Child
- Cholestanetriol 26-Monooxygenase
- Cholesterol
- Cholesterol Side-Chain Cleavage Enzyme
- Chromans
- Chromatin
- Chromatin Immunoprecipitation
- Chrysenes
- Cinnamates
- Cluster Analysis
- Combinatorial Chemistry Techniques
- Consensus Sequence
- Cytoprotection
- DNA Primers
- DNA-Binding Proteins
- Dehydroepiandrosterone
- Dieldrin
- Diethylstilbestrol
- Dose-Response Relationship, Drug
- Down-Regulation
- Drug Design
- Drug Discovery
- Drug Evaluation, Preclinical
- Drug Interactions
- Drug Partial Agonism
- Drug Resistance
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Drug Synergism
- E2F1 Transcription Factor
- Enhancer Elements, Genetic
- Enzyme Activation
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Estradiol
- Estradiol Antagonists
- Estradiol Congeners
- Estrenes
- Estriol
- Estrogen Antagonists
- Estrogen Receptor Modulators
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Estrogen Replacement Therapy
- Estrogens
- Estrogens, Non-Steroidal
- Estrone
- Extracellular Matrix
- Female
- Flow Cytometry
- Furylfuramide
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Expression Regulation, Neoplastic
- Gene Library
- Genes, Reporter
- Glucose
- Glucose Transporter Type 1
- Gonadal Steroid Hormones
- Green Fluorescent Proteins
- HCT116 Cells
- HEK293 Cells
- Haplorhini
- HeLa Cells
- Heat-Shock Proteins
- Hematopoiesis
- Hepatocyte Nuclear Factor 4
- Hexokinase
- Histone Acetyltransferases
- Histone Deacetylase Inhibitors
- Homeodomain Proteins
- Hormone Antagonists
- Humans
- Hydroxycholesterols
- Hydroxymethylglutaryl-CoA Synthase
- Immunoblotting
- Immunohistochemistry
- Immunosuppressive Agents
- Indoles
- Induced Pluripotent Stem Cells
- Inflammatory Breast Neoplasms
- Insecticides
- Insulin-Like Growth Factor I
- Interleukin-1beta
- Intracellular Signaling Peptides and Proteins
- Kruppel-Like Transcription Factors
- Leupeptins
- Ligands
- Lipofuscin
- Lipoproteins, LDL
- Locus Coeruleus
- MCF-7 Cells
- MSX1 Transcription Factor
- Macrophages
- Macular Degeneration
- Male
- Mammary Glands, Human
- Metribolone
- Mice
- Mice, Congenic
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, Knockout
- Mice, Nude
- Mice, SCID
- Mice, Transgenic
- Microscopy, Electron
- Middle Aged
- Mifepristone
- Mitochondria
- Mitogen-Activated Protein Kinases
- Molecular Conformation
- Molecular Sequence Data
- Molecular Targeted Therapy
- Multiple Myeloma
- Mutagenesis, Site-Directed
- NF-kappa B
- Norepinephrine
- Nuclear Receptor Co-Repressor 1
- Nuclear Receptor Co-Repressor 2
- Nuclear Receptor Coactivator 1
- Nuclear Receptor Coactivator 2
- Nuclear Receptor Coactivators
- Organ Size
- Orphan Nuclear Receptors
- Osteoblasts
- Osteoclasts
- Osteogenesis
- Osteoporosis
- Ovariectomy
- Oxidation-Reduction
- PPAR gamma
- Peptide Library
- Peroxidase
- Peroxisome Proliferator-Activated Receptors
- Phenols
- Pigment Epithelium of Eye
- Plicamycin
- Polymerase Chain Reaction
- Progesterone
- Progestins
- Promegestone
- Promoter Regions, Genetic
- Prostate-Specific Antigen
- Prostatic Neoplasms
- Protein Conformation
- Protein Kinase Inhibitors
- Protein Kinases
- Protein Stability
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Protein-Serine-Threonine Kinases
- Proteins
- Proteolysis
- RNA Interference
- RNA, Messenger
- RNA, Small Interfering
- RNA-Binding Proteins
- Raloxifene
- Rats
- Rats, Sprague-Dawley
- Rats, Wistar
- Reactive Oxygen Species
- Receptor Cross-Talk
- Receptor, IGF Type 1
- Receptor, erbB-2
- Receptors, Androgen
- Receptors, Aryl Hydrocarbon
- Receptors, CXCR4
- Receptors, Calcitriol
- Receptors, Cytoplasmic and Nuclear
- Receptors, Estrogen
- Receptors, Glucocorticoid
- Receptors, Progesterone
- Receptors, Retinoic Acid
- Receptors, Steroid
- Recombinant Fusion Proteins
- Recombinant Proteins
- Repetitive Sequences, Nucleic Acid
- Repressor Proteins
- Response Elements
- Retinal Dehydrogenase
- Retinal Pigment Epithelium
- Retinoblastoma Protein
- Retinoid X Receptor alpha
- Retinoid X Receptors
- Retinoids
- Reverse Transcriptase Polymerase Chain Reaction
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Selective Estrogen Receptor Modulators
- Sequence Deletion
- Species Specificity
- Stem Cell Transplantation
- Steroid 17-alpha-Hydroxylase
- Steroid Hydroxylases
- Steroids
- Stilbenes
- Structure-Activity Relationship
- T-Lymphocytes
- Tacrolimus Binding Proteins
- Tamoxifen
- Thiazolidinediones
- Tight Junctions
- Toxaphene
- Trans-Activators
- Transcription Factor AP-1
- Transcription Factors
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Translocation, Genetic
- Tretinoin
- Tumor Burden
- Two-Hybrid System Techniques
- Ubiquitin-Protein Ligase Complexes
- Ubiquitin-Protein Ligases
- Up-Regulation
- Uterus
- Vascular Endothelial Growth Factor A
- Wnt Proteins
- Young Adult
- beta Catenin
- Research
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Selected Grants
- Elucidation of the mechanisms by which cells recognize and respond to different levels of androgens awarded by National Institutes of Health 2022 - 2027
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer awarded by National Institutes of Health 2019 - 2025
- Exploitation of a new targetable node in the AR signaling pathway in prostate cancer awarded by Department of Defense 2022 - 2025
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Uncovering novel gene regulatory mechanisms underlying glucocorticoid response phenotypes through targeted mutagenesis of an essential transcription factor awarded by National Institutes of Health 2022 - 2025
- Institutional Summer Undergraduate Research Fellowship (SURF) awarded by American Society for Pharmacology and Experimental Therapeutics 2018 - 2025
- Development of Novel ERRalpha Antagonists as Breast Cancer Therapeutics awarded by National Institutes of Health 2022 - 2024
- A DUAL ROLE OF INTEGRIN ALPHA-3 IN BREAST CANCER CNS METASTASIS & CHEMORESISTANCE (F31) awarded by National Institutes of Health 2021 - 2024
- Duke University Program in Environmental Health awarded by National Institutes of Health 2019 - 2024
- Endocrinology and Metabolism Training Program (T32) awarded by National Institutes of Health 2019 - 2024
- Understanding metabolic vulnerabilities in cancer and the impact the tumor microenvironment has on cancer progression awarded by National Institutes of Health 2020 - 2024
- Targeting the GRHL2/AGR2/LYPD3 axis in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2018 - 2024
- The role of CaMKK2 in tumor-infiltrating natural killer cells awarded by National Institutes of Health 2021 - 2024
- Functional and Mechanistic Dissection of GPCR Endosomal Signaling Dynamics awarded by National Institutes of Health 2022 - 2024
- CaMKK2 inhibition as an approach to increase tumor immunity in breast cancers awarded by Department of Defense 2020 - 2023
- Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors awarded by Department of Defense 2018 - 2023
- HOXB13 as a therapeutic target in prostate cancer awarded by Prostate Cancer Foundation 2020 - 2023
- Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy awarded by National Institutes of Health 2021 - 2022
- Regulatory principles of the Warburg Effect awarded by American Cancer Society, Inc. 2017 - 2022
- Defining the Rules of Breast Cancer Cell Traffic Through Bone awarded by National Institutes of Health 2017 - 2022
- Identification of Novel Targets in Treatment Resistant Prostate Cancer awarded by Celgene Corporation 2017 - 2022
- Role of ER RNA Binding Domain in Breast Cancer awarded by Ribometrix LLC 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2022
- Targeting tumor-specific apoptosis regulation in advanced ER+ breast cancer awarded by Department of Defense 2019 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Pharmacological targeting of estrogen receptor to enhance melanoma immunity awarded by The Melanoma Research Foundation 2019 - 2021
- Understanding methionine metabolism and its therapeutic potential in cancer awarded by National Institutes of Health 2019 - 2021
- Identification of actionable networks promoting breast cancer progression and brain metastasis awarded by Department of Defense 2018 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Developing in vivo active probes for CAMKK2 to treat cancer awarded by University of North Carolina - Chapel Hill 2017 - 2020
- Immune modulation of CaMKK2 in the ovarian tumor microenvironment awarded by American Association of Obstetricians and Gynecologists Foundation 2019 - 2020
- RIP140 as a mediator of Estrogen Receptor action in tumor associated macrophages awarded by National Institutes of Health 2017 - 2020
- Targeting precursor neural (N)-cadherin to eliminate chemotherapy-resistant triple-negative breast tumor cells awarded by Department of Defense 2017 - 2020
- Role of Cholesterol Efflux Blockade in Mycobacterial Infection In Vivo awarded by National Institutes of Health 2017 - 2020
- ER and LXR as mediators of the pathobiology of hypercholesterolemia awarded by National Institutes of Health 1997 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Hypercholesterolemia as a modifier of the tumor microenvironment in breast cancer awarded by Department of Defense 2016 - 2019
- Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
- Development of mechanistically distinct androgen receptor antagonists and degraders for the treatment of advanced castration resistant prostate cancer awarded by Department of Defense 2015 - 2019
- Effects of dietary methionine restriction on tumor growth and epigenetics awarded by American Cancer Society, Inc. 2018 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- The Role of Epigenetic Plasticity in Breast Cancer Recurrence awarded by National Institutes of Health 2018 - 2019
- Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
- Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- A Novel Function for ALK4 in Suppressing Breast Cancer Progression awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- Developing small-molecule probes of protein arginine methyltransferases awarded by National Institutes of Health 2015 - 2018
- Seahorse XFe96 Extracellular Flux Analyzer awarded by North Carolina Biotechnology Center 2017 - 2018
- Targeting the synthetic essential kinases of breast cancers awarded by Department of Defense 2015 - 2018
- Optimization of ERalpa-LBD-based CAR-T switch awarded by Cell Design Labs, Inc 2017 - 2018
- The role of ERRalpha/PGC-1 in disease pathogenesis awarded by National Institutes of Health 2006 - 2018
- CaMKK2: a druggable target that regulates macrophage function in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2013 - 2017
- Control of the apoptosome in epithelial ovarian cancer to enhance chemotherapy awarded by National Institutes of Health 2014 - 2017
- Evaluation of the therapeutic potential of combining VT464 and G1T38 in treatment-resistant prostate and breast cancer models awarded by Innocrin Pharmaceutical, Inc. 2016 - 2017
- Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis awarded by National Institutes of Health 2011 - 2017
- Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration awarded by National Institutes of Health 2011 - 2017
- Metabolism of Effector T cells as a Target in SLE awarded by Vanderbilt University 2015 - 2017
- BC123577: Targeting Epigenetics Therapy for Estrogen Receptor Negative Breast Cancers awarded by United States Army Medical Research and Materiel Command 2013 - 2016
- Targeting the CDK 4/6 axis in Castration Resistant Prostate Cancer awarded by G1 Therapeutics Inc. 2015 - 2016
- Targeting aerobic glycolysis in T-ALL awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Identification of a novel target for treating breast cancer metastasis awarded by American Cancer Society, Inc. 2014 - 2016
- Evaluation of VT-464 in AR positive and ER positive breast cancer models awarded by Innocrin Pharmaceutical, Inc. 2015 - 2016
- Androgen receptor degradation as a therapeutic modality in castrate resistant prostate cancer awarded by Arvinas Inc. 2015
- T cell metabolism as a determinant of differentiation in allergic asthma awarded by National Institutes of Health 2011 - 2015
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Determination of the antiandrogenic properties of VT-464, a novel CYP17 lyase inhibitor awarded by Viamet Pharmaceuticals 2014 - 2015
- B cell metabolism in activation and autoantibody production awarded by National Institutes of Health 2013 - 2015
- Molecular pharmacology of bazedoxifene and pipendoxifene in breast cancer awarded by Pfizer, Inc. 2013 - 2014
- 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis awarded by National Institutes of Health 2013 - 2014
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- Molecular Determinants of Androgen Receptor Pharmacology awarded by National Institutes of Health 2003 - 2013
- Nonclassical signaling of the androgen receptor polyproline domain awarded by National Institutes of Health 2009 - 2010
- G Protein Involvement in Oncogenesis and Metastasis awarded by National Institutes of Health 2004 - 2009
- Integrated instrument systems for maintenance and delivery of RNAi libraries awarded by National Institutes of Health 2008 - 2009
- The Androgen Receptor: Cofactor Interface awarded by National Institutes of Health 2002 - 2005
- Development and Use of Systems to Study Estrogen Action awarded by National Institutes of Health 2002
- RAR-Beta Mediated Apoptosis in Breast Cancer Cells awarded by National Institutes of Health 1995 - 2000
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External Relationships
- Bristol-Myers Squibb
- RAPPTA Therapeutics
- Radius Health
- Sermonix Pharmaceuticals
- X-Rad Therapeutics
- Zentalis (was called Zeno)
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Chakraborty, Binita, Jovita Byemerwa, Taylor Krebs, Felicia Lim, Ching-Yi Chang, and Donald P. McDonnell. “Estrogen Receptor Signaling in the Immune System.” Endocr Rev 44, no. 1 (January 12, 2023): 117–41. https://doi.org/10.1210/endrev/bnac017.Full Text Link to Item
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Juras, Patrick K., Luigi Racioppi, Debarati Mukherjee, Sandeep Artham, Xia Gao, Laura Akullian D’Agostino, Ching-Yi Chang, and Donald P. McDonnell. “Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells.” Cancer Immunol Res 11, no. 1 (January 3, 2023): 109–22. https://doi.org/10.1158/2326-6066.CIR-22-0391.Full Text Link to Item
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Artham, Sandeep, Ching-Yi Chang, and Donald P. McDonnell. “Eosinophilia in cancer and its regulation by sex hormones.” Trends Endocrinol Metab 34, no. 1 (January 2023): 5–20. https://doi.org/10.1016/j.tem.2022.11.002.Full Text Link to Item
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Tsuji, Junko, Tianyu Li, Albert Grinshpun, Tim Coorens, Douglas Russo, Leilani Anderson, Rebecca Rees, et al. “Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor-Positive Breast Cancer.” Clin Cancer Res 28, no. 23 (December 1, 2022): 5066–78. https://doi.org/10.1158/1078-0432.CCR-22-2305.Full Text Link to Item
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Tomaszewski, William H., Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, et al. “Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.” Nat Commun 13, no. 1 (October 29, 2022): 6483. https://doi.org/10.1038/s41467-022-34175-y.Full Text Link to Item
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Sha, Yonggang, Jian Wu, Barry Paul, Yue Zhao, Parker Mathews, Zhiguo Li, John Norris, Endi Wang, Donald P. McDonnell, and Yubin Kang. “PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo.” Cancer Lett 545 (October 1, 2022): 215832. https://doi.org/10.1016/j.canlet.2022.215832.Full Text Link to Item
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Russell, Shonagh, Felicia Lim, Pamela N. Peters, Suzanne E. Wardell, Regina Whitaker, Ching-Yi Chang, Rebecca A. Previs, and Donald P. McDonnell. “Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer.” Cancers (Basel) 14, no. 17 (August 30, 2022). https://doi.org/10.3390/cancers14174219.Full Text Open Access Copy Link to Item
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Sammeta, Vamshikrishna Reddy, John D. Norris, Sandeep Artham, Chad D. Torrice, Jovita Byemerwa, Carstyn Joiner, Sean W. Fanning, Donald P. McDonnell, and Timothy M. Willson. “A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-d]pyrimidine Core.” Acs Med Chem Lett 13, no. 7 (July 14, 2022): 1151–58. https://doi.org/10.1021/acsmedchemlett.2c00180.Full Text Link to Item
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Haines, Corinne N., Suzanne E. Wardell, and Donald P. McDonnell. “Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer.” Essays Biochem 65, no. 6 (December 17, 2021): 985–1001. https://doi.org/10.1042/EBC20200174.Full Text Link to Item
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Chakraborty, Binita, Jovita Byemerwa, Jonathan Shepherd, Corinne N. Haines, Robert Baldi, Weida Gong, Wen Liu, et al. “Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma.” J Clin Invest 131, no. 23 (December 1, 2021). https://doi.org/10.1172/JCI151347.Full Text Open Access Copy Link to Item
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Lowder, Leah L., Matthew Powell, Sean E. Miller, Rigel J. Kishton, Charles B. Kelly, Connor B. Cribb, Kelly Mastro-Kishton, et al. “Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells.” J Med Chem 64, no. 17 (September 9, 2021): 12651–69. https://doi.org/10.1021/acs.jmedchem.1c00615.Full Text Link to Item
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Liu, Wen, Binita Chakraborty, Rachid Safi, Dmitri Kazmin, Ching-Yi Chang, and Donald P. McDonnell. “Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer.” Nat Commun 12, no. 1 (August 24, 2021): 5103. https://doi.org/10.1038/s41467-021-25354-4.Full Text Link to Item
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McDonnell, Donald P., Suzanne E. Wardell, Ching-Yi Chang, and John D. Norris. “Next-Generation Endocrine Therapies for Breast Cancer.” J Clin Oncol 39, no. 12 (April 20, 2021): 1383–88. https://doi.org/10.1200/JCO.20.03565.Full Text Link to Item
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Andreano, Kaitlyn J., Jennifer G. Baker, Sunghee Park, Rachid Safi, Sandeep Artham, Steffi Oesterreich, Rinath Jeselsohn, et al. “The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor.” Mol Cancer Ther 19, no. 7 (July 2020): 1395–1405. https://doi.org/10.1158/1535-7163.MCT-19-1148.Full Text Link to Item
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Wardell, Suzanne E., Alexander P. Yllanes, Christina A. Chao, Yeeun Bae, Kaitlyn J. Andreano, Taylor K. Desautels, Kendall A. Heetderks, Jeremy T. Blitzer, John D. Norris, and Donald P. McDonnell. “Correction to: Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy.” Breast Cancer Res Treat 179, no. 3 (February 2020): 769. https://doi.org/10.1007/s10549-019-05498-0.Full Text Link to Item
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Wardell, Suzanne E., Alexander P. Yllanes, Christina A. Chao, Yeeun Bae, Kaitlyn J. Andreano, Taylor K. Desautels, Kendall A. Heetderks, Jeremy T. Blitzer, John D. Norris, and Donald P. McDonnell. “Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy.” Breast Cancer Res Treat 179, no. 1 (January 2020): 67–77. https://doi.org/10.1007/s10549-019-05454-y.Full Text Link to Item
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Ochsner, Scott A., David Abraham, Kirt Martin, Wei Ding, Apollo McOwiti, Wasula Kankanamge, Zichen Wang, et al. “The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways.” Sci Data 6, no. 1 (October 31, 2019): 252. https://doi.org/10.1038/s41597-019-0193-4.Full Text Link to Item
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Cocce, Kimberly J., Jeff S. Jasper, Taylor K. Desautels, Logan Everett, Suzanne Wardell, Thomas Westerling, Robert Baldi, et al. “The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.” Cell Rep 29, no. 4 (October 22, 2019): 889-903.e10. https://doi.org/10.1016/j.celrep.2019.09.032.Full Text Link to Item
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Gaillard, Stéphanie L., Kaitlyn J. Andreano, Laurie M. Gay, Meghan Steiner, Matthew S. Jorgensen, Brittany Anne Davidson, Laura J. Havrilesky, et al. “Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.” Gynecol Oncol 154, no. 1 (July 2019): 199–206. https://doi.org/10.1016/j.ygyno.2019.04.010.Full Text Link to Item
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Park, Sunghee, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-Yi Chang, and Donald P. McDonnell. “Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.” Cell Rep 27, no. 12 (June 18, 2019): 3587-3601.e4. https://doi.org/10.1016/j.celrep.2019.05.066.Full Text Link to Item
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Racioppi, Luigi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, et al. “CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.” Nature Communications 10, no. 1 (June 2019): 2450. https://doi.org/10.1038/s41467-019-10424-5.Full Text
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Coons, Laurel A., Adam B. Burkholder, Sylvia C. Hewitt, Donald P. McDonnell, and Kenneth S. Korach. “Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome.” Iscience 15 (May 31, 2019): 552–91. https://doi.org/10.1016/j.isci.2019.04.006.Full Text Link to Item
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Johng, Dorhyun, Gonzalo Torga, Charles M. Ewing, Kideok Jin, John D. Norris, Donald P. McDonnell, and William B. Isaacs. “HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer.” Prostate 79, no. 4 (March 2019): 414–24. https://doi.org/10.1002/pros.23747.Full Text Link to Item
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Wardell, Suzanne E., John D. Norris, and Donald P. McDonnell. “Targeting mutant estrogen receptors.” Elife 8 (January 16, 2019). https://doi.org/10.7554/eLife.44181.Full Text Link to Item
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Chang, Po-Yin, David Feldman, Marcia L. Stefanick, Donald P. McDonnell, Bonne M. Thompson, Jeffrey G. McDonald, and Jennifer S. Lee. “27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative.” J Bone Miner Res 34, no. 1 (January 2019): 59–66. https://doi.org/10.1002/jbmr.3576.Full Text Link to Item
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Singh, Brijesh K., Rohit A. Sinha, Madhulika Tripathi, Arturo Mendoza, Kenji Ohba, Jann A. C. Sy, Sherwin Y. Xie, et al. “Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.” Sci Signal 11, no. 536 (June 26, 2018). https://doi.org/10.1126/scisignal.aam5855.Full Text Link to Item
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Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-Ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell, and Kris C. Wood. “Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors.” Nat Commun 9, no. 1 (April 26, 2018): 1677. https://doi.org/10.1038/s41467-018-04033-x.Full Text Link to Item
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Tria, George S., Tinya Abrams, Jason Baird, Heather E. Burks, Brant Firestone, L Alex Gaither, Lawrence G. Hamann, et al. “Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.” J Med Chem 61, no. 7 (April 12, 2018): 2837–64. https://doi.org/10.1021/acs.jmedchem.7b01682.Full Text Link to Item
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McLeod, Abigail B., James P. Stice, Suzanne E. Wardell, Holly M. Alley, Ching-Yi Chang, and Donald P. McDonnell. “Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.” Prostate 78, no. 4 (March 2018): 266–77. https://doi.org/10.1002/pros.23467.Full Text Link to Item
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McDonnell, Donald P., John D. Norris, and Ching-Yi Chang. “Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.” Cancer Cell 33, no. 2 (February 12, 2018): 153–55. https://doi.org/10.1016/j.ccell.2018.01.014.Full Text Open Access Copy Link to Item
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Salami, Jemilat, Shanique Alabi, Ryan R. Willard, Nick J. Vitale, Jing Wang, Hanqing Dong, Meizhong Jin, et al. “Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance.” Commun Biol 1 (2018): 100. https://doi.org/10.1038/s42003-018-0105-8.Full Text Link to Item
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Baek, Amy E., Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, et al. “The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.” Nat Commun 8, no. 1 (October 11, 2017): 864. https://doi.org/10.1038/s41467-017-00910-z.Full Text Link to Item
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Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.” Cell Metab 26, no. 4 (October 3, 2017): 648-659.e8. https://doi.org/10.1016/j.cmet.2017.08.017.Full Text Link to Item
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Coons, Laurel A., Sylvia C. Hewitt, Adam B. Burkholder, Donald P. McDonnell, and Kenneth S. Korach. “DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin.” Endocrinology 158, no. 10 (October 1, 2017): 3212–34. https://doi.org/10.1210/en.2017-00468.Full Text Link to Item
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Tang, X., C. -. K. Ding, J. Wu, J. Sjol, S. Wardell, I. Spasojevic, D. George, et al. “Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.” Oncogene 36, no. 30 (July 27, 2017): 4235–42. https://doi.org/10.1038/onc.2016.394.Full Text Link to Item
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Tang, X., C. -. K. Ding, J. Wu, J. Sjol, S. Wardell, I. Spasojevic, D. George, et al. “Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.” Oncogene 36, no. 30 (July 27, 2017): 4379. https://doi.org/10.1038/onc.2017.192.Full Text Link to Item
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Kimbung, Siker, Ching-Yi Chang, Pär-Ola Bendahl, Laura Dubois, J Will Thompson, Donald P. McDonnell, and Signe Borgquist. “Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.” Endocr Relat Cancer 24, no. 7 (July 2017): 339–49. https://doi.org/10.1530/ERC-16-0533.Full Text Link to Item
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Stice, James P., Suzanne E. Wardell, John D. Norris, Alexander P. Yllanes, Holly M. Alley, Victoria O. Haney, Hannah S. White, et al. “CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.” Mol Cancer Res 15, no. 6 (June 2017): 660–69. https://doi.org/10.1158/1541-7786.MCR-17-0028.Full Text Link to Item
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Norris, John D., Stephanie J. Ellison, Jennifer G. Baker, David B. Stagg, Suzanne E. Wardell, Sunghee Park, Holly M. Alley, et al. “Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer.” J Clin Invest 127, no. 6 (June 1, 2017): 2326–38. https://doi.org/10.1172/JCI87328.Full Text Link to Item
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Burks, Heather E., Tinya Abrams, Christina A. Kirby, Jason Baird, Alexander Fekete, Lawrence G. Hamann, Sunkyu Kim, et al. “Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.” J Med Chem 60, no. 7 (April 13, 2017): 2790–2818. https://doi.org/10.1021/acs.jmedchem.6b01468.Full Text Link to Item
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Alfaqih, Mahmoud A., Erik R. Nelson, Wen Liu, Rachid Safi, Jeffery S. Jasper, Everardo Macias, Joseph Geradts, et al. “CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.” Cancer Res 77, no. 7 (April 1, 2017): 1662–73. https://doi.org/10.1158/0008-5472.CAN-16-2738.Full Text Link to Item
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Christenson, Jessica L., Kiel T. Butterfield, Nicole S. Spoelstra, John D. Norris, Jatinder S. Josan, Julie A. Pollock, Donald P. McDonnell, Benita S. Katzenellenbogen, John A. Katzenellenbogen, and Jennifer K. Richer. “MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.” Horm Cancer 8, no. 2 (April 2017): 69–77. https://doi.org/10.1007/s12672-017-0285-6.Full Text Link to Item
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Alexander, Peter B., Rui Chen, Chang Gong, Lifeng Yuan, Jeff S. Jasper, Yi Ding, Geoffrey J. Markowitz, et al. “Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.” J Biol Chem 292, no. 2 (January 13, 2017): 748–59. https://doi.org/10.1074/jbc.M116.754960.Full Text Open Access Copy Link to Item
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Nelson, Erik R., Shenduo Li, Margaret Kennedy, Sturgis Payne, Kelly Kilibarda, Jeffrey Groth, Michelle Bowie, et al. “Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.” Oncotarget 7, no. 51 (December 20, 2016): 84030–42. https://doi.org/10.18632/oncotarget.12767.Full Text Link to Item
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Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, et al. “PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.” Sci Transl Med 8, no. 369 (December 14, 2016): 369ra175. https://doi.org/10.1126/scitranslmed.aae0348.Full Text Open Access Copy Link to Item
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Pollock, Julie A., Suzanne E. Wardell, Alexander A. Parent, David B. Stagg, Stephanie J. Ellison, Holly M. Alley, Christina A. Chao, et al. “Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.” Nat Chem Biol 12, no. 10 (October 2016): 795–801. https://doi.org/10.1038/nchembio.2131.Full Text Link to Item
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Wood, Kris C., Grace R. Anderson, Suzanne E. Wardell, Jeff S. Jasper, Elizabeth M. Stein, Colin A. Martz, Holly M. Alley, et al. “Identification and Therapeutic Inhibition of Pathways Driving Resistance to Targeted Breast Cancer Therapies.” Journal of Womens Health 25, no. 9 (September 1, 2016): 976–976.Link to Item
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Park, Sunghee, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, et al. “ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.” Cell Rep 15, no. 2 (April 12, 2016): 323–35. https://doi.org/10.1016/j.celrep.2016.03.026.Full Text Link to Item
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Xu, Xin, Yun Zhang, Jeff Jasper, Erik Lykken, Peter B. Alexander, Geoffrey J. Markowitz, Donald P. McDonnell, Qi-Jing Li, and Xiao-Fan Wang. “MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.” Oncotarget 7, no. 15 (April 12, 2016): 20381–94. https://doi.org/10.18632/oncotarget.7953.Full Text Link to Item
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Alexander, Stephen Ph, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, et al. “The Concise Guide to PHARMACOLOGY 2015/16: Overview.” Br J Pharmacol 172, no. 24 (December 2015): 5729–43. https://doi.org/10.1111/bph.13347.Full Text Link to Item
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Wardell, Suzanne E., Matthew J. Ellis, Holly M. Alley, Koleen Eisele, Todd VanArsdale, Stephen G. Dann, Kim T. Arndt, et al. “Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.” Clin Cancer Res 21, no. 22 (November 15, 2015): 5121–30. https://doi.org/10.1158/1078-0432.CCR-15-0360.Full Text Link to Item
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Blessing, Alicia M., Sathya Ganesan, Kimal Rajapakshe, Ying Ying Sung, Lakshmi Reddy Bollu, Yan Shi, Edwin Cheung, et al. “Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.” Mol Endocrinol 29, no. 10 (October 2015): 1426–39. https://doi.org/10.1210/me.2015-1079.Full Text Link to Item
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Wardell, Suzanne E., Erik R. Nelson, Christina A. Chao, Holly M. Alley, and Donald P. McDonnell. “Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.” Endocr Relat Cancer 22, no. 5 (October 2015): 713–24. https://doi.org/10.1530/ERC-15-0287.Full Text Link to Item
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Gustafson, Jeffrey L., Taavi K. Neklesa, Carly S. Cox, Anke G. Roth, Dennis L. Buckley, Hyun Seop Tae, Thomas B. Sundberg, et al. “Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.” Angew Chem Int Ed Engl 54, no. 33 (August 10, 2015): 9659–62. https://doi.org/10.1002/anie.201503720.Full Text Link to Item
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Lontay, Beata, Khaldon Bodoor, Adrienn Sipos, Douglas H. Weitzel, David Loiselle, Rachid Safi, Donghai Zheng, et al. “Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.” J Biol Chem 290, no. 29 (July 17, 2015): 17985–98. https://doi.org/10.1074/jbc.M115.658120.Full Text Link to Item
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McDonnell, Donald P., Suzanne E. Wardell, and John D. Norris. “Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer.” J Med Chem 58, no. 12 (June 25, 2015): 4883–87. https://doi.org/10.1021/acs.jmedchem.5b00760.Full Text Link to Item
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Allensworth, Jennifer L., Myron K. Evans, François Bertucci, Amy J. Aldrich, Richard A. Festa, Pascal Finetti, Naoto T. Ueno, et al. “Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.” Mol Oncol 9, no. 6 (June 2015): 1155–68. https://doi.org/10.1016/j.molonc.2015.02.007.Full Text Link to Item
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Choudhary, Mayur, Dmitri Kazmin, Peng Hu, Russell S. Thomas, Donald P. McDonnell, and Goldis Malek. “Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways.” J Pathol 235, no. 1 (January 2015): 101–12. https://doi.org/10.1002/path.4433.Full Text Link to Item
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Martz, Colin A., Kathleen A. Ottina, Katherine R. Singleton, Jeff S. Jasper, Suzanne E. Wardell, Ashley Peraza-Penton, Gray R. Anderson, et al. “Systematic identification of signaling pathways with potential to confer anticancer drug resistance.” Sci Signal 7, no. 357 (December 23, 2014): ra121. https://doi.org/10.1126/scisignal.aaa1877.Full Text Link to Item
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Nelson, Erik R., Ching-yi Chang, and Donald P. McDonnell. “Cholesterol and breast cancer pathophysiology.” Trends Endocrinol Metab 25, no. 12 (December 2014): 649–55. https://doi.org/10.1016/j.tem.2014.10.001.Full Text Link to Item
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McDonnell, D. P., C. -. Y. Chang, and E. R. Nelson. “The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.” Climacteric 17 Suppl 2, no. 0 2 (December 2014): 60–65. https://doi.org/10.3109/13697137.2014.966949.Full Text Link to Item
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Wright, Tricia M., Suzanne E. Wardell, Jeff S. Jasper, James P. Stice, Rachid Safi, Erik R. Nelson, and Donald P. McDonnell. “Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.” Mol Cancer Res 12, no. 12 (December 2014): 1829–39. https://doi.org/10.1158/1541-7786.MCR-14-0195.Full Text Link to Item
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Wardell, Suzanne E., Erik R. Nelson, and Donald P. McDonnell. “From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).” Steroids 90 (November 2014): 30–38. https://doi.org/10.1016/j.steroids.2014.07.013.Full Text Link to Item
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Safi, Rachid, Erik R. Nelson, Satish K. Chitneni, Katherine J. Franz, Daniel J. George, Michael R. Zalutsky, and Donald P. McDonnell. “Copper signaling axis as a target for prostate cancer therapeutics.” Cancer Res 74, no. 20 (October 15, 2014): 5819–31. https://doi.org/10.1158/0008-5472.CAN-13-3527.Full Text Open Access Copy Link to Item
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Gustafsson, Jan-Ake, Benita Katzenellenbogen, J Larry Jameson, Jesse Roth, Shlomo Melmed, Donald McDonnell, Leonard Wartofsky, et al. “Endocrine Society 2014 Laureate Awards.” Horm Cancer 5, no. 5 (October 2014): 339–55. https://doi.org/10.1007/s12672-014-0193-y.Full Text Link to Item
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McDonnell, Donald P., Sunghee Park, Matthew T. Goulet, Jeff Jasper, Suzanne E. Wardell, Ching-Yi Chang, John D. Norris, John R. Guyton, and Erik R. Nelson. “Obesity, cholesterol metabolism, and breast cancer pathogenesis.” Cancer Res 74, no. 18 (September 15, 2014): 4976–82. https://doi.org/10.1158/0008-5472.CAN-14-1756.Full Text Link to Item
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Yang, Jun, Peter J. Fuller, James Morgan, Hirotaka Shibata, Donald P. McDonnell, Colin D. Clyne, and Morag J. Young. “Use of phage display to identify novel mineralocorticoid receptor-interacting proteins.” Mol Endocrinol 28, no. 9 (September 2014): 1571–84. https://doi.org/10.1210/me.2014-1101.Full Text Link to Item
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Stossi, Fabio, Michael J. Bolt, Radhika D. Dandekar, Vasanta Putluri, Akash K. Kaushik, Ching-yi Chang, Maureen M. Mancini, Arun Sreekumar, Donald P. McDonnell, and Michael Alan Mancini. “Bisphenol AP Is a Novel AR Down-Regulator in Castrate Resistant Prostate Cancer Cells Via Modulation of Nuclear Receptors' Networks.” Endocrine Reviews 35, no. 3 (June 1, 2014).Link to Item
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Scholtz, Elizabeth L., Shweta Krishnan, Barry A. Ball, C Jo Corbin, Benjamin C. Moeller, Scott D. Stanley, Karen J. McDowell, Austin L. Hughes, Donald P. McDonnell, and Alan J. Conley. “Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone.” Proc Natl Acad Sci U S A 111, no. 9 (March 4, 2014): 3365–70. https://doi.org/10.1073/pnas.1318163111.Full Text Link to Item
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Shatnawi, A., J. D. Norris, C. Chaveroux, J. S. Jasper, A. B. Sherk, D. P. McDonnell, and V. Giguère. “ELF3 is a repressor of androgen receptor action in prostate cancer cells.” Oncogene 33, no. 7 (February 13, 2014): 862–71. https://doi.org/10.1038/onc.2013.15.Full Text Link to Item
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Weiser, Patrick T., Ching-Yi Chang, Donald P. McDonnell, and Robert N. Hanson. “4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.” Bioorg Med Chem 22, no. 2 (January 15, 2014): 917–26. https://doi.org/10.1016/j.bmc.2013.10.051.Full Text Link to Item
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Nelson, Erik R., Suzanne E. Wardell, Jeff S. Jasper, Sunghee Park, Sunil Suchindran, Matthew K. Howe, Nicole J. Carver, et al. “27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.” Science 342, no. 6162 (November 29, 2013): 1094–98. https://doi.org/10.1126/science.1241908.Full Text Link to Item
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Hu, Peng, Rolf Herrmann, Amanda Bednar, Peter Saloupis, Mary A. Dwyer, Ping Yang, Xiaoping Qi, et al. “Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.” Proc Natl Acad Sci U S A 110, no. 43 (October 22, 2013): E4069–78. https://doi.org/10.1073/pnas.1307574110.Full Text Link to Item
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Wardell, Suzanne E., Erik R. Nelson, Christina A. Chao, and Donald P. McDonnell. “Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.” Clin Cancer Res 19, no. 9 (May 1, 2013): 2420–31. https://doi.org/10.1158/1078-0432.CCR-12-3771.Full Text Link to Item
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Nelson, Erik R., Suzanne E. Wardell, and Donald P. McDonnell. “The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.” Bone 53, no. 1 (March 2013): 42–50. https://doi.org/10.1016/j.bone.2012.11.011.Full Text Link to Item
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Shi, Yan, Jenny J. Han, Jayantha B. Tennakoon, Fabiola F. Mehta, Fatima A. Merchant, Alan R. Burns, Matthew K. Howe, Donald P. McDonnell, and Daniel E. Frigo. “Androgens promote prostate cancer cell growth through induction of autophagy.” Mol Endocrinol 27, no. 2 (February 2013): 280–95. https://doi.org/10.1210/me.2012-1260.Full Text Link to Item
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Nelson, Erik Russell, Suzanne E. Wardell, Matthew K. Howe, Nicole J. Carver, Michihisa Umetani, and Donald P. McDonnell. “Abstract PR3: The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis.” Cancer Research 73, no. 3_Supplement (February 1, 2013): PR3–PR3. https://doi.org/10.1158/1538-7445.tim2013-pr3.Full Text
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Wardell, S. E., D. P. McDonnell, and E. R. Nelson. “Regulation of Bone Cell Function by Estrogens,” January 1, 2013, 329–44. https://doi.org/10.1016/B978-0-12-415853-5.00014-5.Full Text
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Augello, Michael A., Craig J. Burd, Ruth Birbe, Christopher McNair, Adam Ertel, Michael S. Magee, Daniel E. Frigo, et al. “Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes.” J Clin Invest 123, no. 1 (January 2013): 493–508. https://doi.org/10.1172/JCI64750.Full Text Link to Item
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Chang, Ching-yi, and Donald P. McDonnell. “Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer.” Clin Cancer Res 18, no. 22 (November 15, 2012): 6089–95. https://doi.org/10.1158/1078-0432.CCR-11-3221.Full Text Link to Item
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Weiser, Patrick T., Anna B. Williams, Ching-Yi Chang, Donald P. McDonnell, and Robert N. Hanson. “3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.” Bioorg Med Chem Lett 22, no. 21 (November 1, 2012): 6587–90. https://doi.org/10.1016/j.bmcl.2012.09.007.Full Text Link to Item
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Pollock, Julie A., Michelle D. Larrea, Jeff S. Jasper, Donald P. McDonnell, and Dewey G. McCafferty. “Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.” Acs Chem Biol 7, no. 7 (July 20, 2012): 1221–31. https://doi.org/10.1021/cb300108c.Full Text Link to Item
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Wardell, Suzanne E., Dmitri Kazmin, and Donald P. McDonnell. “Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.” Mol Endocrinol 26, no. 7 (July 2012): 1235–48. https://doi.org/10.1210/me.2012-1031.Full Text Link to Item
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Malek, Goldis, Mary Dwyer, and Donald McDonnell. “Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD.” Adv Exp Med Biol 723 (2012): 51–59. https://doi.org/10.1007/978-1-4614-0631-0_8.Full Text Link to Item
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Nelson, Erik R., Carolyn D. DuSell, Xiaojuan Wang, Matthew K. Howe, Glenda Evans, Ryan D. Michalek, Michihisa Umetani, et al. “The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.” Endocrinology 152, no. 12 (December 2011): 4691–4705. https://doi.org/10.1210/en.2011-1298.Full Text Link to Item
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Michalek, Ryan D., Valerie A. Gerriets, Amanda G. Nichols, Makoto Inoue, Dmitri Kazmin, Ching-Yi Chang, Mary A. Dwyer, et al. “Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18348–53. https://doi.org/10.1073/pnas.1108856108.Full Text Link to Item
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Chang, Ching-yi, Dmitri Kazmin, Jeff S. Jasper, Rebecca Kunder, William J. Zuercher, and Donald P. McDonnell. “The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.” Cancer Cell 20, no. 4 (October 18, 2011): 500–510. https://doi.org/10.1016/j.ccr.2011.08.023.Full Text Link to Item
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Bodoor, Khaldon, Beata Lontay, Rachid Safi, Douglas H. Weitzel, David Loiselle, Zhengzheng Wei, Szabolcs Lengyel, Donald P. McDonnell, and Timothy A. Haystead. “Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy.” J Biol Chem 286, no. 36 (September 9, 2011): 31839–51. https://doi.org/10.1074/jbc.M111.270397.Full Text Link to Item
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Wardell, Suzanne E., Jeffrey R. Marks, and Donald P. McDonnell. “The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy.” Biochem Pharmacol 82, no. 2 (July 15, 2011): 122–30. https://doi.org/10.1016/j.bcp.2011.03.031.Full Text Link to Item
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Dwyer, Mary A., Dmitri Kazmin, Peng Hu, Donald P. McDonnell, and Goldis Malek. “Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration.” Mol Endocrinol 25, no. 2 (February 2011): 360–72. https://doi.org/10.1210/me.2010-0392.Full Text Link to Item
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Frigo, Daniel E., Matthew K. Howe, Bryan M. Wittmann, Abigail M. Brunner, Ian Cushman, Qianben Wang, Myles Brown, Anthony R. Means, and Donald P. McDonnell. “CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.” Cancer Res 71, no. 2 (January 15, 2011): 528–37. https://doi.org/10.1158/0008-5472.CAN-10-2581.Full Text Link to Item
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Yang, Jun, Ching-yi Chang, Rachid Safi, James Morgan, Donald P. McDonnell, Peter J. Fuller, Colin D. Clyne, and Morag J. Young. “Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.” Mol Endocrinol 25, no. 1 (January 2011): 32–43. https://doi.org/10.1210/me.2010-0193.Full Text Link to Item
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Kobayashi, Sakiko, James P. Stice, Dmitri Kazmin, Bryan M. Wittmann, Erin A. Kimbrel, Dean P. Edwards, Ching-Yi Chang, and Donald P. McDonnell. “Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.” Mol Endocrinol 24, no. 12 (December 2010): 2292–2302. https://doi.org/10.1210/me.2010-0289.Full Text Link to Item
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McDonnell, Donald P., and Suzanne E. Wardell. “The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer.” Curr Opin Pharmacol 10, no. 6 (December 2010): 620–28. https://doi.org/10.1016/j.coph.2010.09.007.Full Text Link to Item
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Dwyer, Mary A., James D. Joseph, Hilary E. Wade, Matthew L. Eaton, Rebecca S. Kunder, Dmitri Kazmin, Ching-yi Chang, and Donald P. McDonnell. “WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.” Cancer Res 70, no. 22 (November 15, 2010): 9298–9308. https://doi.org/10.1158/0008-5472.CAN-10-0226.Full Text Link to Item
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Orr, Christopher R., Heather L. Montie, Yuhong Liu, Elena Bolzoni, Shannon C. Jenkins, Elizabeth M. Wilson, James D. Joseph, Donald P. McDonnell, and Diane E. Merry. “An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.” J Biol Chem 285, no. 46 (November 12, 2010): 35567–77. https://doi.org/10.1074/jbc.M110.146845.Full Text Link to Item
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DuSell, Carolyn D., Erik R. Nelson, Xiaojuan Wang, Jennifer Abdo, Ulrike I. Mödder, Michihisa Umetani, Diane Gesty-Palmer, Norman B. Javitt, Sundeep Khosla, and Donald P. McDonnell. “The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.” Endocrinology 151, no. 8 (August 2010): 3675–85. https://doi.org/10.1210/en.2010-0080.Full Text Link to Item
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Zhou, X Edward, Kelly Suino-Powell, Phumzile L. Ludidi, Donald P. McDonnell, and H Eric Xu. “Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs.” Protein Expr Purif 71, no. 1 (May 2010): 21–27. https://doi.org/10.1016/j.pep.2009.12.002.Full Text Link to Item
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Wade, Hilary E., Sakiko Kobayashi, Matthew L. Eaton, Michelle S. Jansen, Edward K. Lobenhofer, Mathieu Lupien, Timothy R. Geistlinger, et al. “Multimodal regulation of E2F1 gene expression by progestins.” Mol Cell Biol 30, no. 8 (April 2010): 1866–77. https://doi.org/10.1128/MCB.01060-09.Full Text Link to Item
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Muramoto, Garrett G., J Lauren Russell, Rachid Safi, Alice B. Salter, Heather A. Himburg, Pamela Daher, Sarah K. Meadows, et al. “Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity.” Stem Cells 28, no. 3 (March 31, 2010): 523–34. https://doi.org/10.1002/stem.299.Full Text Link to Item
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McDonnell, Donald P. “The homeodomain protein HOXB13 specifies the cellular response to androgens.” Endocrine Journal 57 (March 1, 2010): S258–59.Link to Item
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Alaynick, William A., James M. Way, Stephanie A. Wilson, William G. Benson, Liming Pei, Michael Downes, Ruth Yu, et al. “ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.” Mol Endocrinol 24, no. 2 (February 2010): 299–309. https://doi.org/10.1210/me.2009-0114.Full Text Link to Item
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Hall, Julie M., Melissa A. Barhoover, Dmitri Kazmin, Donald P. McDonnell, William F. Greenlee, and Russell S. Thomas. “Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation.” Mol Endocrinol 24, no. 2 (February 2010): 359–69. https://doi.org/10.1210/me.2009-0346.Full Text Link to Item
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Chute, John P., Joel R. Ross, and Donald P. McDonnell. “Minireview: Nuclear receptors, hematopoiesis, and stem cells.” Mol Endocrinol 24, no. 1 (January 2010): 1–10. https://doi.org/10.1210/me.2009-0332.Full Text Link to Item
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DuSell, Carolyn D., Erik R. Nelson, Bryan M. Wittmann, Jackie A. Fretz, Dmitri Kazmin, Russell S. Thomas, J Wesley Pike, and Donald P. McDonnell. “Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.” Mol Endocrinol 24, no. 1 (January 2010): 33–46. https://doi.org/10.1210/me.2009-0339.Full Text Link to Item
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Norris, John D., Ching-Yi Chang, Bryan M. Wittmann, Rebecca S. Kunder, Huaxia Cui, Daju Fan, James D. Joseph, and Donald P. McDonnell. “The homeodomain protein HOXB13 regulates the cellular response to androgens.” Mol Cell 36, no. 3 (November 13, 2009): 405–16. https://doi.org/10.1016/j.molcel.2009.10.020.Full Text Link to Item
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Frigo, Daniel E., Andrea B. Sherk, Bryan M. Wittmann, John D. Norris, Qianben Wang, James D. Joseph, Aidan P. Toner, Myles Brown, and Donald P. McDonnell. “Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.” Mol Endocrinol 23, no. 9 (September 2009): 1385–96. https://doi.org/10.1210/me.2009-0010.Full Text Link to Item
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Grasfeder, Linda L., Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-Yi Chang, and Donald P. McDonnell. “Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.” Mol Endocrinol 23, no. 8 (August 2009): 1171–82. https://doi.org/10.1210/me.2009-0024.Full Text Link to Item
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Joseph, James D., Bryan M. Wittmann, Mary A. Dwyer, Huaxia Cui, Delita A. Dye, Donald P. McDonnell, and John D. Norris. “Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.” Proc Natl Acad Sci U S A 106, no. 29 (July 21, 2009): 12178–83. https://doi.org/10.1073/pnas.0900185106.Full Text Link to Item
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Collins, N. H., E. C. Lessey, C. D. DuSell, D. P. McDonnell, L. Fowler, W. A. Palomino, M. J. Illera, et al. “Characterization of antiestrogenic activity of the Chinese herb, Prunella vulgaris, using in vitro and in vivo (mouse xenograft) models (Biology of Reproduction 2009, 80, (375-383) DOI: 10.1095/biolreprod.107.065375).” Biology of Reproduction 80, no. 6 (June 1, 2009): 1306. https://doi.org/10.1095/biolreprod.109.078303.Full Text
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Norris, John David, James David Joseph, Andrea Barreto Sherk, Dalia Juzumiene, Philip Stewart Turnbull, Stephen William Rafferty, Huaxia Cui, et al. “Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.” Chem Biol 16, no. 4 (April 24, 2009): 452–60. https://doi.org/10.1016/j.chembiol.2009.01.016.Full Text Link to Item
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Clyne, Colin D., Ching-Yi Chang, Rachid Safi, Peter J. Fuller, Donald P. McDonnell, and Morag J. Young. “Purification and characterization of recombinant human mineralocorticoid receptor.” Mol Cell Endocrinol 302, no. 1 (April 10, 2009): 81–85. https://doi.org/10.1016/j.mce.2008.11.030.Full Text Link to Item
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Stein, Rebecca A., Stéphanie Gaillard, and Donald P. McDonnell. “Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells.” J Steroid Biochem Mol Biol 114, no. 1–2 (March 2009): 106–12. https://doi.org/10.1016/j.jsbmb.2009.02.010.Full Text Link to Item
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Wardell, Suzanne E., Olga R. Ilkayeva, Heather L. Wieman, Daniel E. Frigo, Jeffrey C. Rathmell, Christopher B. Newgard, and Donald P. McDonnell. “Glucose metabolism as a target of histone deacetylase inhibitors.” Mol Endocrinol 23, no. 3 (March 2009): 388–401. https://doi.org/10.1210/me.2008-0179.Full Text Link to Item
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Collins, Nancy H., Elizabeth C. Lessey, Carolyn D. DuSell, Donald P. McDonnell, Lindsay Fowler, Wilder A. Palomino, Maria J. Illera, et al. “Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models.” Biol Reprod 80, no. 2 (February 2009): 375–83. https://doi.org/10.1095/biolreprod.107.065375.Full Text Link to Item
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Safi, Rachid, Garrett G. Muramoto, Alice B. Salter, Sarah Meadows, Heather Himburg, Lauren Russell, Pamela Daher, et al. “Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.” Mol Endocrinol 23, no. 2 (February 2009): 188–201. https://doi.org/10.1210/me.2008-0121.Full Text Link to Item
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Stein, Rebecca A., Ching-Yi Chang, Dmitri A. Kazmin, James Way, Thies Schroeder, Melanie Wergin, Mark W. Dewhirst, and Donald P. McDonnell. “Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.” Cancer Res 68, no. 21 (November 1, 2008): 8805–12. https://doi.org/10.1158/0008-5472.CAN-08-1594.Full Text Link to Item
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DuSell, Carolyn D., and Donald P. McDonnell. “27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.” Trends Pharmacol Sci 29, no. 10 (October 2008): 510–14. https://doi.org/10.1016/j.tips.2008.07.003.Full Text Link to Item
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Sherk, Andrea B., Daniel E. Frigo, Christine G. Schnackenberg, Jeffrey D. Bray, Nicholas J. Laping, Walter Trizna, Marlys Hammond, et al. “Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.” Cancer Res 68, no. 18 (September 15, 2008): 7475–83. https://doi.org/10.1158/0008-5472.CAN-08-1047.Full Text Link to Item
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Frigo, Daniel E., and Donald P. McDonnell. “Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation.” Mol Cancer Ther 7, no. 3 (March 2008): 659–69. https://doi.org/10.1158/1535-7163.MCT-07-0480.Full Text Link to Item
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DuSell, Carolyn D., Michihisa Umetani, Philip W. Shaul, David J. Mangelsdorf, and Donald P. McDonnell. “27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.” Mol Endocrinol 22, no. 1 (January 2008): 65–77. https://doi.org/10.1210/me.2007-0383.Full Text Link to Item
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McDonnell, D. P. “The commercialism of academic research.” Nature Medicine 14, no. 10 (January 1, 2008): 1014–1014. https://doi.org/10.1038/nm1008-1014.Full Text
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Hyatt, Stephen M., Elizabeth L. Lockamy, Rebecca A. Stein, Donald P. McDonnell, Aaron B. Miller, Lisa A. Orband-Miller, Timothy M. Willson, and William J. Zuercher. “On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.” J Med Chem 50, no. 26 (December 27, 2007): 6722–24. https://doi.org/10.1021/jm7012387.Full Text Link to Item
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Sherk, A. B., and D. P. McDonnell. “Molecular pharmacology of estrogen and progesterone receptors,” December 1, 2007, 17–28. https://doi.org/10.1016/B978-012369443-0/50004-1.Full Text
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Mettu, Niharika B., Thomas B. Stanley, Mary A. Dwyer, Michelle S. Jansen, John E. Allen, Julie M. Hall, and Donald P. McDonnell. “The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors.” Mol Endocrinol 21, no. 10 (October 2007): 2361–77. https://doi.org/10.1210/me.2007-0201.Full Text Link to Item
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Wittmann, Bryan M., Andrea Sherk, and Donald P. McDonnell. “Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.” Cancer Res 67, no. 19 (October 1, 2007): 9549–60. https://doi.org/10.1158/0008-5472.CAN-07-1590.Full Text Link to Item
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Hall, Julie M., and Donald P. McDonnell. “The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages.” Mol Endocrinol 21, no. 8 (August 2007): 1756–68. https://doi.org/10.1210/me.2007-0060.Full Text Link to Item
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Zella, Lee A., Ching-Yi Chang, Donald P. McDonnell, and J Wesley Pike. “The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs.” Arch Biochem Biophys 460, no. 2 (April 15, 2007): 206–12. https://doi.org/10.1016/j.abb.2006.12.016.Full Text Link to Item
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Heldring, Nina, Tanya Pawson, Donald McDonnell, Eckardt Treuter, Jan-Ake Gustafsson, and Ashley C. W. Pike. “Structural insights into corepressor recognition by antagonist-bound estrogen receptors.” J Biol Chem 282, no. 14 (April 6, 2007): 10449–55. https://doi.org/10.1074/jbc.M611424200.Full Text Link to Item
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Gaillard, Stéphanie, Mary A. Dwyer, and Donald P. McDonnell. “Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions.” Mol Endocrinol 21, no. 1 (January 2007): 62–76. https://doi.org/10.1210/me.2006-0179.Full Text Link to Item
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Zhang, Yi, Ke Ma, Prabodh Sadana, Farhana Chowdhury, Stephanie Gaillard, Fang Wang, Donald P. McDonnell, Terry G. Unterman, Marshall B. Elam, and Edwards A. Park. “Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.” J Biol Chem 281, no. 52 (December 29, 2006): 39897–906. https://doi.org/10.1074/jbc.M608657200.Full Text Link to Item
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Gaillard, Stéphanie, Linda L. Grasfeder, Christiane L. Haeffele, Edward K. Lobenhofer, Tzu-Ming Chu, Russ Wolfinger, Dmitri Kazmin, et al. “Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.” Mol Cell 24, no. 5 (December 8, 2006): 797–803. https://doi.org/10.1016/j.molcel.2006.10.012.Full Text Link to Item
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McDonnell, Donald P. “Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators.” Faseb J 20, no. 14 (December 2006): 2432–34. https://doi.org/10.1096/fj.06-1202ufm.Full Text Link to Item
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Stein, R. A., and D. P. McDonnell. “Estrogen-related receptor alpha as a therapeutic target in cancer.” Endocr Relat Cancer 13 Suppl 1 (December 2006): S25–32. https://doi.org/10.1677/erc.1.01292.Full Text Link to Item
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Lu, Nick Z., Suzanne E. Wardell, Kerry L. Burnstein, Donald Defranco, Peter J. Fuller, Vincent Giguere, Richard B. Hochberg, et al. “International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.” Pharmacol Rev 58, no. 4 (December 2006): 782–97. https://doi.org/10.1124/pr.58.4.9.Full Text Link to Item
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Mettu, N. B., M. S. Jansen, M. A. Dwyer, J. M. Hall, T. B. Stanley, and D. P. McDonnell. “The use of conformational peptide probes to aid in the identification of novel PPAR selective modulators.” Inflammation Research 55 (October 1, 2006): S126–27.Link to Item
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Cidlowski, J., M. Birnbaumer, D. DeFranco, M. Hunzicker-Dunn, D. McDonnell, P. Pilch, M. J. Tsai, and M. Haworth. “Research resource articles - A new feature for Molecular Endocrinology.” Molecular Endocrinology 20, no. 9 (August 31, 2006): 1971. https://doi.org/10.1210/me.2006-8931.Full Text
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Chute, John P., Garrett G. Muramoto, John Whitesides, Michael Colvin, Rachid Safi, Nelson J. Chao, and Donald P. McDonnell. “Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.” Proc Natl Acad Sci U S A 103, no. 31 (August 1, 2006): 11707–12. https://doi.org/10.1073/pnas.0603806103.Full Text Link to Item
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Noble, Schroeder M., Virginia E. Carnahan, Linda B. Moore, Tom Luntz, Hongbing Wang, Olivia R. Ittoop, Julie B. Stimmel, et al. “Human PXR forms a tryptophan zipper-mediated homodimer.” Biochemistry 45, no. 28 (July 18, 2006): 8579–89. https://doi.org/10.1021/bi0602821.Full Text Link to Item
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Kazmin, Dmitri, Tatiana Prytkova, C Edgar Cook, Russell Wolfinger, Tzu-Ming Chu, David Beratan, J. D. Norris, Ching-yi Chang, and Donald P. McDonnell. “Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.” Mol Endocrinol 20, no. 6 (June 2006): 1201–17. https://doi.org/10.1210/me.2005-0309.Full Text Link to Item
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Stein, R., J. M. Way, D. P. McDonnell, and W. J. Zuercher. “Estrogen-related receptor α as a therapeutic target.” Drugs of the Future 31, no. 5 (May 1, 2006): 427–36. https://doi.org/10.1358/dof.2006.031.05.994706.Full Text
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Chao, Esther Y. H., Jon L. Collins, Stéphanie Gaillard, Aaron B. Miller, Liping Wang, Lisa A. Orband-Miller, Robert T. Nolte, Donald P. McDonnell, Timothy M. Willson, and William J. Zuercher. “Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.” Bioorg Med Chem Lett 16, no. 4 (February 15, 2006): 821–24. https://doi.org/10.1016/j.bmcl.2005.11.030.Full Text Link to Item
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Solomon, Isaac H., Janet M. Hager, Rachid Safi, Donald P. McDonnell, Matthew R. Redinbo, and Eric A. Ortlund. “Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.” J Mol Biol 354, no. 5 (December 16, 2005): 1091–1102. https://doi.org/10.1016/j.jmb.2005.10.009.Full Text Link to Item
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Safi, Rachid, Agnes Kovacic, Stéphanie Gaillard, Yoko Murata, Evan R. Simpson, Donald P. McDonnell, and Colin D. Clyne. “Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.” Cancer Res 65, no. 24 (December 15, 2005): 11762–70. https://doi.org/10.1158/0008-5472.CAN-05-2792.Full Text Link to Item
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Hall, Julie M., and Donald P. McDonnell. “Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.” Mol Interv 5, no. 6 (December 2005): 343–57. https://doi.org/10.1124/mi.5.6.7.Full Text Link to Item
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Chang, Ching-Yi, Jennifer Abdo, Tanya Hartney, and Donald P. McDonnell. “Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display.” Mol Endocrinol 19, no. 10 (October 2005): 2478–90. https://doi.org/10.1210/me.2005-0072.Full Text Link to Item
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Wu, Ya-Ling, Xiaojing Yang, Zhong Ren, Donald P. McDonnell, John D. Norris, Timothy M. Willson, and Geoffrey L. Greene. “Structural basis for an unexpected mode of SERM-mediated ER antagonism.” Mol Cell 18, no. 4 (May 13, 2005): 413–24. https://doi.org/10.1016/j.molcel.2005.04.014.Full Text Link to Item
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Zuercher, William J., Stéphanie Gaillard, Lisa A. Orband-Miller, Esther Y. H. Chao, Barry G. Shearer, David G. Jones, Aaron B. Miller, Jon L. Collins, Donald P. McDonnell, and Timothy M. Willson. “Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.” J Med Chem 48, no. 9 (May 5, 2005): 3107–9. https://doi.org/10.1021/jm050161j.Full Text Link to Item
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Chang, Ching-yi, and Donald P. McDonnell. “Androgen receptor-cofactor interactions as targets for new drug discovery.” Trends Pharmacol Sci 26, no. 5 (May 2005): 225–28. https://doi.org/10.1016/j.tips.2005.03.002.Full Text Link to Item
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Ortlund, Eric A., Yoonkwang Lee, Isaac H. Solomon, Janet M. Hager, Rachid Safi, Yunhee Choi, Ziqiang Guan, et al. “Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.” Nat Struct Mol Biol 12, no. 4 (April 2005): 357–63. https://doi.org/10.1038/nsmb910.Full Text Link to Item
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Shaffer, Paul L., Donald P. McDonnell, and Daniel T. Gewirth. “Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor.” Biochemistry 44, no. 7 (February 22, 2005): 2678–85. https://doi.org/10.1021/bi0477182.Full Text Link to Item
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Colditz, Graham A. “Estrogen, estrogen plus progestin therapy, and risk of breast cancer.” Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 909s-917s.Link to Item
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Come, S. E., A. U. Buzdar, J. N. Ingle, C. L. Arteaga, A. M. Brodie, G. A. Colditz, S. R. D. Johnston, et al. “Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Conference summary statement.” Clinical Cancer Research 11, no. 2 II (January 15, 2005).
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Come, Steven E., Aman U. Buzdar, James N. Ingle, Carlos L. Arteaga, Angela M. Brodie, Graham A. Colditz, Stephen R. D. Johnston, et al. “Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement.” Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 861s-864s.Link to Item
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Kristensen, Vessela N., Therese Sørlie, Jurgen Geisler, Anita Langerød, Noriko Yoshimura, Rolf Kåresen, Nobuhiro Harada, P. E. Lønning, and Anne-Lise Børresen-Dale. “Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.” Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 878s-883s.Link to Item
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McDonnell, D. P., D. Yee, R. Santen, K. Osborne, and A. Brodie. “The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer.” Clinical Cancer Research 11, no. 2 II (January 15, 2005).
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McDonnell, Donald P. “The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer.” Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 871s-877s.Link to Item
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Yue, Wei, Ji-Ping Wang, Yuebai Li, Wayne P. Bocchinfuso, Kenneth S. Korach, Prabu D. Devanesan, Eleanor Rogan, Ercole Cavalieri, and Richard J. Santen. “Tamoxifen versus aromatase inhibitors for breast cancer prevention.” Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 925s-930s.Link to Item
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Juzumiene, Dalia, Ching-yi Chang, Daju Fan, Tanya Hartney, John D. Norris, and Donald P. McDonnell. “Single-step purification of full-length human androgen receptor.” Nucl Recept Signal 3 (2005): e001. https://doi.org/10.1621/nrs.03001.Full Text Link to Item
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McDonnell, Donald P. “The molecular determinants of estrogen receptor pharmacology.” Maturitas 48 Suppl 1 (August 30, 2004): S7-12. https://doi.org/10.1016/j.maturitas.2004.03.006.Full Text Link to Item
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Shao, Wenlin, Erika Krasnickas Keeton, Donald P. McDonnell, and Myles Brown. “Coactivator AIB1 links estrogen receptor transcriptional activity and stability.” Proc Natl Acad Sci U S A 101, no. 32 (August 10, 2004): 11599–604. https://doi.org/10.1073/pnas.0402997101.Full Text Link to Item
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Turgeon, Judith L., Donald P. McDonnell, Kathryn A. Martin, and Phyllis M. Wise. “Hormone therapy: physiological complexity belies therapeutic simplicity.” Science 304, no. 5675 (May 28, 2004): 1269–73. https://doi.org/10.1126/science.1096725.Full Text Link to Item
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Jansen, Michelle S., Susan C. Nagel, Phillippa J. Miranda, Edward K. Lobenhofer, Cynthia A. Afshari, and Donald P. McDonnell. “Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.” Proc Natl Acad Sci U S A 101, no. 18 (May 4, 2004): 7199–7204. https://doi.org/10.1073/pnas.0402014101.Full Text Link to Item
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Kurebayashi, Shogo, Takeshi Nakajima, Seong-Chul Kim, Ching-Yi Chang, Donald P. McDonnell, Jean-Paul Renaud, and Anton M. Jetten. “Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma.” Biochem Biophys Res Commun 315, no. 4 (March 19, 2004): 919–27. https://doi.org/10.1016/j.bbrc.2004.01.131.Full Text Link to Item
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Glass, Christopher K., and Donald P. McDonnell. “The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology.” Mol Cell 13, no. 4 (February 27, 2004): 459–67. https://doi.org/10.1016/s1097-2765(04)00093-0.Full Text Link to Item
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McDonnell, D. P. “E10. Interpreting the results of the women's health initiative within the context of our current understanding of oestrogen and progesterone action.” European Journal of Cancer, Supplement 2, no. 9 SPEC. ISS. (January 1, 2004): 35–40. https://doi.org/10.1016/j.ejcsup.2004.08.050.Full Text
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Tirado, Oscar M., David M. Selva, Núria Toràn, Carlos A. Suárez-Quian, Michelle Jansen, Donald P. McDonnell, Jaume Reventós, and Francina Munell. “Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration.” J Androl 25, no. 1 (2004): 84–94. https://doi.org/10.1002/j.1939-4640.2004.tb02762.x.Full Text Link to Item
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Sathya, Ganesan, Ching-yi Chang, Dmitri Kazmin, C Edgar Cook, and Donald P. McDonnell. “Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion.” Cancer Res 63, no. 22 (November 15, 2003): 8029–36.Link to Item
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McDonnell, Donald P. “Mining the complexities of the estrogen signaling pathways for novel therapeutics.” Endocrinology 144, no. 10 (October 2003): 4237–40. https://doi.org/10.1210/en.2003-0900.Full Text Link to Item
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Herrington, D. M., T. D. Howard, B. Brosnihan, G. A. Hawkins, D. M. Reboussin, J. F. Xu, S. Q. L. Zheng, et al. “Randomized controlled trial evidence that estrogen replacement therapy reduces the progression of subclinical atherosclerosis in healthy postmenopausal women without preexisting cardiovascular disease - Response.” Circulation 108, no. 1 (July 8, 2003): E5–E5.Link to Item
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Rincavage, Heather L., Donald P. McDonnell, and Cynthia M. Kuhn. “Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.” Endocrinology 144, no. 7 (July 2003): 2829–35. https://doi.org/10.1210/en.2002-221120.Full Text Link to Item
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Pike, J Wesley, Peterman Pathrose, Olga Barmina, Ching-Yi Chang, Donald P. McDonnell, Hironori Yamamoto, and Nirupama K. Shevde. “Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription.” J Cell Biochem 88, no. 2 (February 1, 2003): 252–58. https://doi.org/10.1002/jcb.10336.Full Text Link to Item
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Kimbrel, E. A., and D. P. McDonnell. “Function and mode of action of nuclear receptors: Estrogen, progesterone, and vitamin D.” Pure and Applied Chemistry 75, no. 11–12 (January 1, 2003): 1671–83. https://doi.org/10.1351/pac200375111671.Full Text
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McDonnell, D. P., and P. Miranda. “The impact of the women's health initiative on the search for improved treatments for the conditions associated with long-term oestrogen deprivation.” Journal of the British Menopause Society 9, no. SUPPL. 2 (January 1, 2003): 4–10. https://doi.org/10.1258/136218003323023364.Full Text
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Chang, Ching-yi, John D. Norris, Michelle Jansen, Huey-Jing Huang, and Donald P. McDonnell. “Application of random peptide phage display to the study of nuclear hormone receptors.” Methods Enzymol 364 (2003): 118–42. https://doi.org/10.1016/s0076-6879(03)64007-3.Full Text Link to Item
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Pathrose, Peterson, Olga Barmina, Ching-Yi Chang, Donald P. McDonnell, Nirupama K. Shevde, and J Wesley Pike. “Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.” J Bone Miner Res 17, no. 12 (December 2002): 2196–2205. https://doi.org/10.1359/jbmr.2002.17.12.2196.Full Text Link to Item
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Safe, Stephen H., Lea Pallaroni, Kyungsil Yoon, Kevin Gaido, Susan Ross, and Donald McDonnell. “Problems for risk assessment of endocrine-active estrogenic compounds.” Environ Health Perspect 110 Suppl 6, no. Suppl 6 (December 2002): 925–29. https://doi.org/10.1289/ehp.02110s6925.Full Text Link to Item
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Huang, Huey-Jing, John D. Norris, and Donald P. McDonnell. “Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists.” Mol Endocrinol 16, no. 8 (August 2002): 1778–92. https://doi.org/10.1210/me.2002-0089.Full Text Link to Item
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Sathya, Ganesan, Michelle S. Jansen, Susan C. Nagel, C Edgar Cook, and Donald P. McDonnell. “Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins.” Endocrinology 143, no. 8 (August 2002): 3071–82. https://doi.org/10.1210/endo.143.8.8942.Full Text Link to Item
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Sathya, Ganesan, Michelle S. Jansen, Susan C. Nagel, C Edgar Cook, and Donald P. McDonnell. “Identification and Characterization of Novel Estrogen Receptor-β-Sparing Antiprogestins.” Endocrinology 143, no. 8 (August 1, 2002): 3071–82. https://doi.org/10.1210/endo.143.8.8942.Full Text Link to Item
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McDonnell, Donald P., Ashini Wijayaratne, Ching-yi Chang, and John D. Norris. “Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.” Am J Cardiol 90, no. 1A (July 3, 2002): 35F-43F. https://doi.org/10.1016/s0002-9149(01)02221-4.Full Text Link to Item
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Li, Xiaolin, Erin A. Kimbrel, Daniel J. Kenan, and Donald P. McDonnell. “Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.” Mol Endocrinol 16, no. 7 (July 2002): 1482–91. https://doi.org/10.1210/mend.16.7.0860.Full Text Link to Item
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Li, Xiaolin, and Donald P. McDonnell. “The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.” Mol Cell Biol 22, no. 11 (June 2002): 3663–73. https://doi.org/10.1128/MCB.22.11.3663-3673.2002.Full Text Link to Item
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McDonnell, Donald P., and John D. Norris. “Connections and regulation of the human estrogen receptor.” Science 296, no. 5573 (May 31, 2002): 1642–44. https://doi.org/10.1126/science.1071884.Full Text Link to Item
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Herrington, David M., Timothy D. Howard, K Bridget Brosnihan, Donald P. McDonnell, Xiaolin Li, Gregory A. Hawkins, David M. Reboussin, et al. “Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein.” Circulation 105, no. 16 (April 23, 2002): 1879–82. https://doi.org/10.1161/01.cir.0000016173.98826.88.Full Text Link to Item
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Chang, Ching-Yi, and Donald P. McDonnell. “Evaluation of ligand-dependent changes in AR structure using peptide probes.” Mol Endocrinol 16, no. 4 (April 2002): 647–60. https://doi.org/10.1210/mend.16.4.0818.Full Text Link to Item
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Hall, Julie M., Donald P. McDonnell, and Kenneth S. Korach. “Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.” Mol Endocrinol 16, no. 3 (March 2002): 469–86. https://doi.org/10.1210/mend.16.3.0814.Full Text Link to Item
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Norris, John D., Daju Fan, Andrea Sherk, and Donald P. McDonnell. “A negative coregulator for the human ER.” Mol Endocrinol 16, no. 3 (March 2002): 459–68. https://doi.org/10.1210/mend.16.3.0787.Full Text Link to Item
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Weatherman, R. V., C. -. Y. Chang, N. J. Clegg, D. C. Carroll, R. N. Day, J. D. Baxter, D. P. McDonnell, T. S. Scanlan, and F. Schaufele. “Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer.” Mol Endocrinol 16, no. 3 (March 2002): 487–96. https://doi.org/10.1210/mend.16.3.0813.Full Text Link to Item
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McDonnell, Donald P., Caroline E. Connor, Ashini Wijayaratne, Ching-Yi Chang, and John D. Norris. “Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.” Recent Prog Horm Res 57 (2002): 295–316. https://doi.org/10.1210/rp.57.1.295.Full Text Link to Item
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Chang, C. Y., P. J. Walther, and D. P. McDonnell. “Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer.” Cancer Res 61, no. 24 (December 15, 2001): 8712–17.Link to Item
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McDonnell, D. P., C. Y. Chang, and J. D. Norris. “Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM.” Ann N Y Acad Sci 949 (December 2001): 16–35. https://doi.org/10.1111/j.1749-6632.2001.tb03999.x.Full Text Link to Item
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Nagel, S. C., J. L. Hagelbarger, and D. P. McDonnell. “Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.” Endocrinology 142, no. 11 (November 2001): 4721–28. https://doi.org/10.1210/endo.142.11.8471.Full Text Link to Item
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Wijayaratne, A. L., and D. P. McDonnell. “The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators.” J Biol Chem 276, no. 38 (September 21, 2001): 35684–92. https://doi.org/10.1074/jbc.M101097200.Full Text Link to Item
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Pathrose, P., C. Y. Chang, D. P. McDonnell, and J. W. Pike. “Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic peptide antagonists that target the activation domain of retinoid X receptor.” Journal of Bone and Mineral Research 16 (September 1, 2001): S184–S184.Link to Item
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Hamilton, M. H., I. Tcherepanova, J. M. Huibregtse, and D. P. McDonnell. “Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates.” J Biol Chem 276, no. 28 (July 13, 2001): 26324–31. https://doi.org/10.1074/jbc.M101205200.Full Text Link to Item
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McDonnell, D. P., C. E. Connor, J. Hall, C. Y. Chang, M. S. Jansen, and J. D. Norris. “The molecular pharmacology of estrogen receptor agonists, antagonists and SERMs.” Bone 28, no. 5 (May 1, 2001): S68–S68.Link to Item
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Connor, C. E., J. D. Norris, G. Broadwater, T. M. Willson, M. M. Gottardis, M. W. Dewhirst, and D. P. McDonnell. “Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.” Cancer Res 61, no. 7 (April 1, 2001): 2917–22.Link to Item
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Norris, J. D., C. Chang, and D. P. McDonnell. “Estrogen receptor-cofactor interactions as targets for novel drug discovery.” Ernst Schering Res Found Workshop, no. 34 (2001): 181–201. https://doi.org/10.1007/978-3-662-04645-6_10.Full Text Link to Item
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Safe, S. H., L. Pallaroni, K. Yoon, K. Gaido, S. Ross, B. Saville, and D. McDonnellc. “Toxicology of environmental estrogens.” Reprod Fertil Dev 13, no. 4 (2001): 307–15. https://doi.org/10.1071/rd00108.Full Text Link to Item
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Hall, J. M., C. Y. Chang, and D. P. McDonnell. “Development of peptide antagonists that target estrogen receptor beta-coactivator interactions.” Mol Endocrinol 14, no. 12 (December 2000): 2010–23. https://doi.org/10.1210/mend.14.12.0561.Full Text Link to Item
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Schaufele, F., C. Y. Chang, W. Liu, J. D. Baxter, S. K. Nordeen, Y. Wan, R. N. Day, and D. P. McDonnell. “Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor.” Mol Endocrinol 14, no. 12 (December 2000): 2024–39. https://doi.org/10.1210/mend.14.12.0572.Full Text Link to Item
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McDonnell, D. P., C. Y. Chang, and J. D. Norris. “Development of peptide antagonists that target estrogen receptor-cofactor interactions.” J Steroid Biochem Mol Biol 74, no. 5 (November 30, 2000): 327–35. https://doi.org/10.1016/s0960-0760(00)00109-6.Full Text Link to Item
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Gaido, K. W., S. C. Maness, D. P. McDonnell, S. S. Dehal, D. Kupfer, and S. Safe. “Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.” Mol Pharmacol 58, no. 4 (October 2000): 852–58.Link to Item
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Tcherepanova, I., P. Puigserver, J. D. Norris, B. M. Spiegelman, and D. P. McDonnell. “Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.” J Biol Chem 275, no. 21 (May 26, 2000): 16302–8. https://doi.org/10.1074/jbc.M001364200.Full Text Link to Item
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Giangrande, P. H., E. A. Kimbrel, D. P. Edwards, and D. P. McDonnell. “The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.” Mol Cell Biol 20, no. 9 (May 2000): 3102–15. https://doi.org/10.1128/MCB.20.9.3102-3115.2000.Full Text Link to Item
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McDonnell, D. P. “Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen.” J Soc Gynecol Investig 7, no. 1 Suppl (2000): S10–15. https://doi.org/10.1016/s1071-5576(99)00055-6.Full Text Link to Item
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Chang, C. Y., J. D. Norris, H. Grøn, L. A. Paige, P. T. Hamilton, D. J. Kenan, D. Fowlkes, and D. P. McDonnell. “Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.” Mol Cell Biol 19, no. 12 (December 1999): 8226–39. https://doi.org/10.1128/MCB.19.12.8226.Full Text Link to Item
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Gaido, K. W., L. S. Leonard, S. C. Maness, J. M. Hall, D. P. McDonnell, B. Saville, and S. Safe. “Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.” Endocrinology 140, no. 12 (December 1999): 5746–53. https://doi.org/10.1210/endo.140.12.7191.Full Text Link to Item
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Gaido, Kevin W., Linda S. Leonard, Susan C. Maness, Julie M. Hall, Donald P. McDonnell, Brad Saville, and Stephen Safe. “Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors α and β1.” Endocrinology 140, no. 12 (December 1, 1999): 5746–53. https://doi.org/10.1210/endo.140.12.7191.Full Text Link to Item
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Hall, J. M., and D. P. McDonnell. “The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.” Endocrinology 140, no. 12 (December 1999): 5566–78. https://doi.org/10.1210/endo.140.12.7179.Full Text Link to Item
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Hall, Julie M., and Donald P. McDonnell. “The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1.” Endocrinology 140, no. 12 (December 1, 1999): 5566–78. https://doi.org/10.1210/endo.140.12.7179.Full Text Link to Item
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Wijayaratne, A. L., S. C. Nagel, L. A. Paige, D. J. Christensen, J. D. Norris, D. M. Fowlkes, and D. P. McDonnell. “Comparative analyses of mechanistic differences among antiestrogens.” Endocrinology 140, no. 12 (December 1999): 5828–40. https://doi.org/10.1210/endo.140.12.7164.Full Text Link to Item
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Wijayaratne, Ashini L., Susan C. Nagel, Lisa A. Paige, Dale J. Christensen, John D. Norris, Dana M. Fowlkes, and Donald P. McDonnell. “Comparative Analyses of Mechanistic Differences Among Antiestrogens1.” Endocrinology 140, no. 12 (December 1, 1999): 5828–40. https://doi.org/10.1210/endo.140.12.7164.Full Text Link to Item
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Beaudenon, S. L., M. R. Huacani, G. Wang, D. P. McDonnell, and J. M. Huibregtse. “Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae.” Mol Cell Biol 19, no. 10 (October 1999): 6972–79. https://doi.org/10.1128/MCB.19.10.6972.Full Text Link to Item
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McDonnell, D. P. “The Molecular Pharmacology of SERMs.” Trends Endocrinol Metab 10, no. 8 (October 1999): 301–11. https://doi.org/10.1016/s1043-2760(99)00177-0.Full Text Link to Item
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Norris, J. D., L. A. Paige, D. J. Christensen, C. Y. Chang, M. R. Huacani, D. Fan, P. T. Hamilton, D. M. Fowlkes, and D. P. McDonnell. “Peptide antagonists of the human estrogen receptor.” Science 285, no. 5428 (July 30, 1999): 744–46. https://doi.org/10.1126/science.285.5428.744.Full Text Link to Item
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Tetel, M. J., P. H. Giangrande, S. A. Leonhardt, D. P. McDonnell, and D. P. Edwards. “Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.” Mol Endocrinol 13, no. 6 (June 1999): 910–24. https://doi.org/10.1210/mend.13.6.0300.Full Text Link to Item
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Improta-Brears, T., A. R. Whorton, F. Codazzi, J. D. York, T. Meyer, and D. P. McDonnell. “Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.” Proc Natl Acad Sci U S A 96, no. 8 (April 13, 1999): 4686–91. https://doi.org/10.1073/pnas.96.8.4686.Full Text Link to Item
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Paige, L. A., D. J. Christensen, H. Grøn, J. D. Norris, E. B. Gottlin, K. M. Padilla, C. Y. Chang, et al. “Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.” Proc Natl Acad Sci U S A 96, no. 7 (March 30, 1999): 3999–4004. https://doi.org/10.1073/pnas.96.7.3999.Full Text Link to Item
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Wagner, B. L., G. Pollio, P. Giangrande, J. C. Webster, M. Breslin, D. E. Mais, C. E. Cook, W. V. Vedeckis, J. A. Cidlowski, and D. P. McDonnell. “The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins.” Endocrinology 140, no. 3 (March 1, 1999): 1449–58. https://doi.org/10.1210/endo.140.3.6581.Full Text Link to Item
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Giangrande, P. H., and D. P. McDonnell. “The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.” Recent Prog Horm Res 54 (1999): 291–313.Link to Item
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McDonnell, D. P. “Wyeth lederle recent advances in conjugated estrogens estrogen action 1998: new insights. new drugs, new issues.” International Journal of Fertility and Menopausal Studies 43, no. 4 (December 1, 1998): 222.
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Gould, J. C., L. S. Leonard, S. C. Maness, B. L. Wagner, K. Conner, T. Zacharewski, S. Safe, D. P. McDonnell, and K. W. Gaido. “Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.” Mol Cell Endocrinol 142, no. 1–2 (July 25, 1998): 203–14. https://doi.org/10.1016/s0303-7207(98)00084-7.Full Text Link to Item
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Maness, S. C., D. P. McDonnell, and K. W. Gaido. “Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.” Toxicol Appl Pharmacol 151, no. 1 (July 1998): 135–42. https://doi.org/10.1006/taap.1998.8431.Full Text Link to Item
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Ramamoorthy, K., F. Wang, I. C. Chen, S. Safe, J. D. Norris, D. P. McDonnell, K. W. Gaido, et al. “Potency of combined estrogenic pesticides: Synergy between synthetic oestrogens?” Chemtracts 11, no. 4 (April 1, 1998): 306–8.
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Norris, J. D., D. Fan, M. R. Stallcup, and D. P. McDonnell. “Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology.” J Biol Chem 273, no. 12 (March 20, 1998): 6679–88. https://doi.org/10.1074/jbc.273.12.6679.Full Text Link to Item
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Wagner, B. L., J. D. Norris, T. A. Knotts, N. L. Weigel, and D. P. McDonnell. “The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.” Mol Cell Biol 18, no. 3 (March 1998): 1369–78. https://doi.org/10.1128/MCB.18.3.1369.Full Text Link to Item
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McDonnell, D. P. “Definition of the molecular mechanism of action of tissue-selective oestrogen-receptor modulators.” Biochem Soc Trans 26, no. 1 (February 1998): 54–60. https://doi.org/10.1042/bst0260054.Full Text Link to Item
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Giangrande, P. H., G. Pollio, and D. P. McDonnell. “Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor.” J Biol Chem 272, no. 52 (December 26, 1997): 32889–900. https://doi.org/10.1074/jbc.272.52.32889.Full Text Link to Item
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Ramamoorthy, K., C. Vyhlidal, F. Wang, I. Chen, S. Safe, D. P. McDonnell, L. S. Leonard, and K. W. Gaido. “Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.” Toxicol Appl Pharmacol 147, no. 1 (November 1997): 93–100. https://doi.org/10.1006/taap.1997.8281.Full Text Link to Item
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Willson, T. M., J. D. Norris, B. L. Wagner, I. Asplin, P. Baer, H. R. Brown, S. A. Jones, et al. “Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.” Endocrinology 138, no. 9 (September 1997): 3901–11. https://doi.org/10.1210/endo.138.9.5358.Full Text Link to Item
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Coldham, N. G., M. Dave, S. Sivapathasundaram, D. P. McDonnell, C. Connor, and M. J. Sauer. “Evaluation of a recombinant yeast cell estrogen screening assay.” Environ Health Perspect 105, no. 7 (July 1997): 734–42. https://doi.org/10.1289/ehp.97105734.Full Text Link to Item
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Norris, J. D., D. Fan, S. A. Kerner, and D. P. McDonnell. “Identification of a third autonomous activation domain within the human estrogen receptor.” Mol Endocrinol 11, no. 6 (June 1997): 747–54. https://doi.org/10.1210/mend.11.6.0008.Full Text Link to Item
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Ramamoorthy, K., F. Wang, I. C. Chen, J. D. Norris, D. P. McDonnell, L. S. Leonard, K. W. Gaido, W. P. Bocchinfuso, K. S. Korach, and S. Safe. “Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.” Endocrinology 138, no. 4 (April 1997): 1520–27. https://doi.org/10.1210/endo.138.4.5056.Full Text Link to Item
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Gaido, K. W., L. S. Leonard, S. Lovell, J. C. Gould, D. Babaï, C. J. Portier, and D. P. McDonnell. “Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.” Toxicol Appl Pharmacol 143, no. 1 (March 1997): 205–12. https://doi.org/10.1006/taap.1996.8069.Full Text Link to Item
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Ramamoorthy, K., F. Wang, I. C. Chen, S. Safe, J. D. Norris, D. P. McDonnell, K. W. Gaido, W. P. Bocchinfuso, and K. S. Korach. “Potency of combined estrogenic pesticides.” Science 275, no. 5298 (January 17, 1997): 405–6. https://doi.org/10.1126/science.275.5298.405.Full Text Link to Item
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Marks, J. R., G. Huper, J. P. Vaughn, P. L. Davis, J. Norris, D. P. McDonnell, R. W. Wiseman, P. A. Futreal, and J. D. Iglehart. “BRCA1 expression is not directly responsive to estrogen.” Oncogene 14, no. 1 (January 9, 1997): 115–21. https://doi.org/10.1038/sj.onc.1200808.Full Text Link to Item
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Norris, J., D. Fan, and D. P. McDonnell. “Erratum: Identification of the sequences within the human coplement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity (Molecular Endocrinology (1996) 10 (1605-1616)).” Molecular Endocrinology 11, no. 3 (January 1, 1997): 341.
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McDonnell, D. P., and J. D. Norris. “Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone.” Osteoporos Int 7 Suppl 1 (1997): S29–34. https://doi.org/10.1007/BF01674810.Full Text Link to Item
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Fan, J. D., B. L. Wagner, and D. P. McDonnell. “Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.” Mol Endocrinol 10, no. 12 (December 1996): 1605–16. https://doi.org/10.1210/mend.10.12.8961270.Full Text Link to Item
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Wagner, B. L., G. Pollio, S. Leonhardt, M. C. Wani, D. Y. Lee, M. O. Imhof, D. P. Edwards, C. E. Cook, and D. P. McDonnell. “16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.” Proc Natl Acad Sci U S A 93, no. 16 (August 6, 1996): 8739–44. https://doi.org/10.1073/pnas.93.16.8739.Full Text Link to Item
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Imhof, M. O., and D. P. McDonnell. “Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors.” Mol Cell Biol 16, no. 6 (June 1996): 2594–2605. https://doi.org/10.1128/MCB.16.6.2594.Full Text Link to Item
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Vegeto, E., B. L. Wagner, M. O. Imhof, and D. P. McDonnell. “The molecular pharmacology of ovarian steroid receptors.” Vitam Horm 52 (1996): 99–128. https://doi.org/10.1016/s0083-6729(08)60408-2.Full Text Link to Item
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Gardener, J., and D. McDonnell. “Impact of process changes on the physical properties and formability of silver metal oxide contact materials.” Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts, December 1, 1995, 373–80.
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Norris, J., D. Fan, C. Aleman, J. R. Marks, P. A. Futreal, R. W. Wiseman, J. D. Iglehart, P. L. Deininger, and D. P. McDonnell. “Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers.” J Biol Chem 270, no. 39 (September 29, 1995): 22777–82. https://doi.org/10.1074/jbc.270.39.22777.Full Text Link to Item
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McDonnell, D. P., S. L. Dana, P. A. Hoener, B. A. Lieberman, M. O. Imhof, and R. B. Stein. “Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor.” Ann N Y Acad Sci 761 (June 12, 1995): 121–37. https://doi.org/10.1111/j.1749-6632.1995.tb31374.x.Full Text Link to Item
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Clemm, D. L., B. L. Macy, D. Santiso-Mere, and D. P. McDonnell. “Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.” J Steroid Biochem Mol Biol 53, no. 1–6 (June 1995): 487–95. https://doi.org/10.1016/0960-0760(95)00095-h.Full Text Link to Item
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McDonnell, D. P., D. L. Clemm, T. Hermann, M. E. Goldman, and J. W. Pike. “Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.” Mol Endocrinol 9, no. 6 (June 1995): 659–69. https://doi.org/10.1210/mend.9.6.8592512.Full Text Link to Item
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Wen, D. X., and D. P. McDonnell. “Advances in our understanding of ligand-activated nuclear receptors.” Current Opinion in Biotechnology 6, no. 5 (January 1, 1995): 582–89. https://doi.org/10.1016/0958-1669(95)80096-4.Full Text
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McDonnell, D. P. “Unraveling the human progesterone receptor signal transduction pathway Insights into antiprogestin action.” Trends Endocrinol Metab 6, no. 4 (1995): 133–38. https://doi.org/10.1016/1043-2760(95)00065-p.Full Text Link to Item
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McDonnell, D. “Comparison of the switching behavior of internally oxidized and powder metallurgical silver metal oxide contact materials.” Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts, December 1, 1994, 253–60.
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Klein, K. O., J. Baron, M. J. Colli, D. P. McDonnell, and G. B. Cutler. “Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay.” J Clin Invest 94, no. 6 (December 1994): 2475–80. https://doi.org/10.1172/JCI117616.Full Text Link to Item
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Wen, D. X., Y. F. Xu, D. E. Mais, M. E. Goldman, and D. P. McDonnell. “The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.” Mol Cell Biol 14, no. 12 (December 1994): 8356–64. https://doi.org/10.1128/mcb.14.12.8356-8364.1994.Full Text Link to Item
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Mukherjee, R., L. Jow, D. Noonan, and D. P. McDonnell. “Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators.” J Steroid Biochem Mol Biol 51, no. 3–4 (November 1994): 157–66. https://doi.org/10.1016/0960-0760(94)90089-2.Full Text Link to Item
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McDonnell, D. P., D. L. Clemm, and M. O. Imhof. “Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.” Semin Cancer Biol 5, no. 5 (October 1994): 327–36.Link to Item
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Tai, P. K., M. W. Albers, D. P. McDonnell, H. Chang, S. L. Schreiber, and L. E. Faber. “Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.” Biochemistry 33, no. 35 (September 6, 1994): 10666–71. https://doi.org/10.1021/bi00201a014.Full Text Link to Item
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Dana, S. L., P. A. Hoener, D. A. Wheeler, C. B. Lawrence, and D. P. McDonnell. “Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.” Mol Endocrinol 8, no. 9 (September 1994): 1193–1207. https://doi.org/10.1210/mend.8.9.7838152.Full Text Link to Item
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Crombie, D. L., R. Mukherjee, D. P. McDonnell, J. S. Hayes, and M. W. Wang. “Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment.” J Steroid Biochem Mol Biol 49, no. 2–3 (June 1994): 123–29. https://doi.org/10.1016/0960-0760(94)90002-7.Full Text Link to Item
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McDonnell, D. P., and M. E. Goldman. “RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.” J Biol Chem 269, no. 16 (April 22, 1994): 11945–49.Link to Item
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McDonnell, D. P., M. M. Shahbaz, E. Vegeto, and M. E. Goldman. “The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity.” J Steroid Biochem Mol Biol 48, no. 5–6 (April 1994): 425–32. https://doi.org/10.1016/0960-0760(94)90190-2.Full Text Link to Item
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Kepa, J. K., C. I. Neeley, B. M. Jacobsen, J. M. Bruder, D. P. McDonnell, K. K. Leslie, and M. E. Wierman. “Estrogen receptor mediated repression of rat gonadotropin releasing hormone (GnRH) promoter activity in hypothalamic cells.” Endocrine 2, no. 10 (January 1, 1994): 947–56.
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Tzukerman, M. T., A. Esty, D. Santiso-Mere, P. Danielian, M. G. Parker, R. B. Stein, J. W. Pike, and D. P. McDonnell. “Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.” Mol Endocrinol 8, no. 1 (January 1994): 21–30. https://doi.org/10.1210/mend.8.1.8152428.Full Text Link to Item
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McDonnell, D. P., B. Clevenger, S. Dana, D. Santiso-Mere, M. T. Tzukerman, and M. A. Gleeson. “The mechanism of action of steroid hormones: a new twist to an old tale.” J Clin Pharmacol 33, no. 12 (December 1993): 1165–72. https://doi.org/10.1002/j.1552-4604.1993.tb03916.x.Full Text Link to Item
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McDonnell, D., J. Gardener, and J. Gondusky. “Comparison of the switching behavior of silver metal oxide contact materials.” Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts, December 1, 1993, 37–43.
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McDonnell, D. P., E. Vegeto, and M. A. Gleeson. “Nuclear hormone receptors as targets for new drug discovery.” Biotechnology (N Y) 11, no. 11 (November 1993): 1256–61. https://doi.org/10.1038/nbt1193-1256.Full Text Link to Item
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Andrews, E., R. Jansen, A. M. Crane, S. Cholin, D. McDonnell, and F. D. Ledley. “Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae.” Biochem Med Metab Biol 50, no. 2 (October 1993): 135–44. https://doi.org/10.1006/bmmb.1993.1055.Full Text Link to Item
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Vegeto, E., M. M. Shahbaz, D. X. Wen, M. E. Goldman, B. W. O’Malley, and D. P. McDonnell. “Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.” Mol Endocrinol 7, no. 10 (October 1993): 1244–55. https://doi.org/10.1210/mend.7.10.8264658.Full Text Link to Item
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Poletti, A., O. M. Conneely, D. P. McDonnell, W. T. Schrader, B. W. O’Malley, and N. L. Weigel. “Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.” Biochemistry 32, no. 37 (September 21, 1993): 9563–69. https://doi.org/10.1021/bi00088a007.Full Text Link to Item
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Santiso-Mere, D., T. Sone, G. M. Hilliard, J. W. Pike, and D. P. McDonnell. “Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems.” Mol Endocrinol 7, no. 7 (July 1993): 833–39. https://doi.org/10.1210/mend.7.7.8413308.Full Text Link to Item
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Nawaz, Z., G. M. Stancel, D. P. McDonnell, and S. M. Hyder. “Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis?” Mol Carcinog 7, no. 2 (1993): 76–82. https://doi.org/10.1002/mc.2940070204.Full Text Link to Item
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McDonnell, D. P., E. Vegeto, and B. W. O’Malley. “Identification of a negative regulatory function for steroid receptors.” Proc Natl Acad Sci U S A 89, no. 22 (November 15, 1992): 10563–67. https://doi.org/10.1073/pnas.89.22.10563.Full Text Link to Item
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Hyder, S. M., G. M. Stancel, Z. Nawaz, D. P. McDonnell, and D. S. Loose-Mitchell. “Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.” J Biol Chem 267, no. 25 (September 5, 1992): 18047–54.Link to Item
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Pham, T. A., Y. P. Hwung, D. Santiso-Mere, D. P. McDonnell, and B. W. O’Malley. “Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.” Mol Endocrinol 6, no. 7 (July 1992): 1043–50. https://doi.org/10.1210/mend.6.7.1508220.Full Text Link to Item
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Wooge, C. H., G. M. Nilsson, A. Heierson, D. P. McDonnell, and B. S. Katzenellenbogen. “Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells.” Mol Endocrinol 6, no. 6 (June 1992): 861–69. https://doi.org/10.1210/mend.6.6.1495491.Full Text Link to Item
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Vegeto, E., G. F. Allan, W. T. Schrader, M. J. Tsai, D. P. McDonnell, and B. W. O’Malley. “The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.” Cell 69, no. 4 (May 15, 1992): 703–13. https://doi.org/10.1016/0092-8674(92)90234-4.Full Text Link to Item
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Poletti, A., N. L. Weigel, D. P. McDonnell, W. T. Schrader, B. W. O’Malley, and O. M. Conneely. “A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae.” Gene 114, no. 1 (May 1, 1992): 51–58. https://doi.org/10.1016/0378-1119(92)90706-u.Full Text Link to Item
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Pham, T. A., D. P. McDonnell, M. J. Tsai, and B. W. O’Malley. “Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes.” Biochemistry 31, no. 5 (February 11, 1992): 1570–78. https://doi.org/10.1021/bi00120a039.Full Text Link to Item
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Fuqua, S. A. W., S. D. Fitzgerald, D. C. Allred, R. M. Elledge, Z. Nawaz, D. P. McDonnell, B. W. O’Malley, G. L. Greene, and W. L. McGuire. “Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.” Cancer Research 52, no. 2 (1992): 483–86.
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Nawaz, Z., M. J. Tsai, D. P. McDonnell, and B. W. O’Malley. “Identification of novel steroid-response elements.” Gene Expr 2, no. 1 (1992): 39–47.Link to Item
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Pham, T. A., Y. P. Hwung, D. P. McDonnell, and B. W. O’Malley. “Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo.” J Biol Chem 266, no. 27 (September 25, 1991): 18179–87.Link to Item
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McDonnell, D. P., Z. Nawaz, and B. W. O’Malley. “In situ distinction between steroid receptor binding and transactivation at a target gene.” Mol Cell Biol 11, no. 9 (September 1991): 4350–55. https://doi.org/10.1128/mcb.11.9.4350-4355.1991.Full Text Link to Item
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McDonnell, D. P., Z. Nawaz, C. Densmore, N. L. Weigel, T. A. Pham, J. H. Clark, and B. W. O’Malley. “High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.” J Steroid Biochem Mol Biol 39, no. 3 (September 1991): 291–97. https://doi.org/10.1016/0960-0760(91)90038-7.Full Text Link to Item
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Pham, T. A., J. F. Elliston, Z. Nawaz, D. P. McDonnell, M. J. Tsai, and B. W. O’Malley. “Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.” Proc Natl Acad Sci U S A 88, no. 8 (April 15, 1991): 3125–29. https://doi.org/10.1073/pnas.88.8.3125.Full Text Link to Item
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Fuqua, S. A. W., S. D. Fitzgerald, G. C. Chamness, A. K. Tandon, D. P. McDonnell, Z. Nawaz, B. W. O’Malley, and W. L. McGuire. “Variant human breast tumor estrogen receptor with constitutive transcriptional activity.” Cancer Research 51, no. 1 (1991): 105–9.
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Sone, T., D. P. McDonnell, B. W. O’Malley, and J. W. Pike. “Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies.” J Biol Chem 265, no. 35 (December 15, 1990): 21997–3.Link to Item
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Liao, J., K. Ozono, T. Sone, D. P. McDonnell, and J. W. Pike. “Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.” Proc Natl Acad Sci U S A 87, no. 24 (December 1990): 9751–55. https://doi.org/10.1073/pnas.87.24.9751.Full Text Link to Item
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Power, R. F., O. M. Conneely, D. P. McDonnell, J. H. Clark, T. R. Butt, W. T. Schrader, and B. W. O’Malley. “High level expression of a truncated chicken progesterone receptor in Escherichia coli.” J Biol Chem 265, no. 3 (January 25, 1990): 1419–24.Link to Item
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Mak, P., D. P. McDonnell, N. L. Weigel, W. T. Schrader, and B. W. O’Malley. “Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae).” J Biol Chem 264, no. 36 (December 25, 1989): 21613–18.Link to Item
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McDonnell, D. P., J. W. Pike, D. J. Drutz, T. R. Butt, and B. W. O’Malley. “Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.” Mol Cell Biol 9, no. 8 (August 1989): 3517–23. https://doi.org/10.1128/mcb.9.8.3517-3523.1989.Full Text Link to Item
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McDonnell, D. P., R. A. Scott, S. A. Kerner, B. W. O’Malley, and J. W. Pike. “Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression.” Mol Endocrinol 3, no. 4 (April 1989): 635–44. https://doi.org/10.1210/mend-3-4-635.Full Text Link to Item
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Hughes, M., P. Malloy, D. Kieback, D. McDonnell, D. Feldman, J. W. Pike, and B. O’Malley. “Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets.” Adv Exp Med Biol 255 (1989): 491–503. https://doi.org/10.1007/978-1-4684-5679-0_52.Full Text Link to Item
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Baker, A. R., D. P. McDonnell, M. Hughes, T. M. Crisp, D. J. Mangelsdorf, M. R. Haussler, J. W. Pike, J. Shine, and B. W. O’Malley. “Cloning and expression of full-length cDNA encoding human vitamin D receptor.” Proc Natl Acad Sci U S A 85, no. 10 (May 1988): 3294–98. https://doi.org/10.1073/pnas.85.10.3294.Full Text Link to Item
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Haussler, M. R., D. J. Mangelsdorf, B. S. Komm, C. M. Terpening, K. Yamaoka, E. A. Allegretto, A. R. Baker, J. Shine, D. P. McDonnell, and M. Hughes. “Molecular biology of the vitamin D hormone.” Recent Prog Horm Res 44 (1988): 263–305. https://doi.org/10.1016/b978-0-12-571144-9.50013-2.Full Text Link to Item
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McDonnell, D. P., J. W. Pike, and B. W. O’Malley. “The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor.” J Steroid Biochem 30, no. 1–6 (1988): 41–46. https://doi.org/10.1016/0022-4731(88)90074-x.Full Text Link to Item
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Mangelsdorf, D. J., B. S. Komm, D. P. McDonnell, J. W. Pike, and M. R. Haussler. “Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone.” Biochemistry 26, no. 25 (December 15, 1987): 8332–38. https://doi.org/10.1021/bi00399a046.Full Text Link to Item
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McDonnell, D. P., D. J. Mangelsdorf, J. W. Pike, M. R. Haussler, and B. W. O’Malley. “Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.” Science 235, no. 4793 (March 6, 1987): 1214–17. https://doi.org/10.1126/science.3029866.Full Text Link to Item
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Maxwell, B. L., D. P. McDonnell, O. M. Conneely, T. Z. Schulz, G. L. Greene, and B. W. O’Malley. “Structural organization and regulation of the chicken estrogen receptor.” Mol Endocrinol 1, no. 1 (January 1987): 25–35. https://doi.org/10.1210/mend-1-1-25.Full Text Link to Item
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Lawrence, C. B., D. P. McDonnell, and W. J. Ramsey. “Analysis of repetitive sequence elements containing tRNA-like sequences.” Nucleic Acids Res 13, no. 12 (June 25, 1985): 4239–52. https://doi.org/10.1093/nar/13.12.4239.Full Text Link to Item
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Book Sections
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Grasfeder, L. L., and D. P. McDonnell. “Nuclear receptor cofactor interactions as targets for new drug discovery.” In NR Coregulators and Human Diseases, 572–99, 2008. https://doi.org/10.1142/9789812819178_0019.Full Text
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Conference Papers
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Mukherjee, Debarati, Robert Baldi, Ching-Yi Chang, Luigi Racioppi, and Donald P. McDonnell. “Impact of CaMKK2 inhibition in tumor-associated myeloid cells on CD8+cytotoxic T-cell recruitment into mammary tumors.” In Cancer Immunology Research, 8:56–57. AMER ASSOC CANCER RESEARCH, 2020.Link to Item
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Sammons, Sarah, Grace Anderson, Suzanne Wardell, Donald P. McDonnell, Paul Kelly Marcom, and Kris Wood. “Combination mTORC1/2 and BCL- XL inhibition in endocrine and CDK4/6-resistant estrogen receptor-positive breast cancer.” In Journal of Clinical Oncology, 37:e14653–e14653. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.e14653.Full Text
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Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product.” In Cancer Research, 78:5496–5496. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-5496.Full Text
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Gaillard, Stephanie, Laurie M. Gay, Meghan Steiner, Kaitlyn Andreano, Brittany Anne Davidson, Laura Jean Havrilesky, Angeles Alvarez Secord, et al. “Assessment of activating estrogen receptor 1 (ESR1) mutations in gynecologic malignancies.” In Journal of Clinical Oncology, 36:5590–5590. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.5590.Full Text
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Kimbung, S., C. -. Y. Chang, P. -. O. Bendahl, L. Dubois, W. J. Thompson, D. P. McDonnell, and S. Borgquist. “Impact of the sterol 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol on tumor-pathological features, prognosis and response to statin treatment in breast cancer.” In Annals of Oncology, Vol. 28. OXFORD UNIV PRESS, 2017.Link to Item
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Quayle, L., S. Park, D. P. McDonnell, P. D. Ottewell, and I. Holen. “Abstract P3-07-14: Targeting ERR-α regulated lactate metabolism eliminates drug-resistant breast cancer cells.” In Cancer Research, Vol. 77. American Association for Cancer Research (AACR), 2017. https://doi.org/10.1158/1538-7445.sabcs16-p3-07-14.Full Text
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Alfaqih, M., E. R. Nelson, W. Liu, R. Safi, J. S. Jasper, E. Macias, J. Geradts, C. Y. Chang, D. P. McDonnell, and S. Freedland. “CYP27A1/27HC/SREBP2 axis is a novel therapeutic target in prostate cancer.” In European Journal of Cancer, 69:S42–43. Elsevier BV, 2016. https://doi.org/10.1016/s0959-8049(16)32708-3.Full Text
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Ellison, S. J., J. D. Norris, S. Wardell, J. R. Eisner, W. J. Hoekstra, D. B. Stagg, H. M. Alley, W. R. Moore, and D. P. McDonnell. “Abstract P3-14-04: Effects of the dual selective CYP17 lyase inhibitor and androgen receptor (AR) antagonist, VT-464, on AR+ and ER+ tumor models in vitro and in vivo.” In Cancer Research, Vol. 76. American Association for Cancer Research (AACR), 2016. https://doi.org/10.1158/1538-7445.sabcs15-p3-14-04.Full Text
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Alwarawrah, Yazan, Philip Hughes, Rachid Safi, Donald P. McDonnell, Neil L. Spector, and Timothy A. Haystead. “Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106.” In Cancer Research, 75:2703–2703. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1538-7445.am2015-2703.Full Text
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Moore, William R., John D. Norris, Suzanne Wardell, Joel Robert Eisner, William J. Hoekstra, Robert J. Schotzinger, and Donald P. McDonnell. “Direct effects of the selective CYP17 lyase (L) inhibitor, VT-464, on the androgen receptor (AR) and its oral activity in an F876L tumor mouse xenograft model.” In Journal of Clinical Oncology, 33:263–263. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.7_suppl.263.Full Text
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Alfaqih, Mahmoud A., Erik R. Nelson, Rachid Safi, Jeff Jasper, Ching-yi Chang, Stephen J. Freedland, and Donald P. McDonnell. “Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer.” In Cancer Research, 74:3311–3311. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1538-7445.am2014-3311.Full Text
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Stevens, Ellen V., Regina Whitaker, Audrey Guinet, Ching-Yi Chang, Carole Grenier, Jeffrey Marks, Donald P. McDonnell, Susan K. Murphy, Andrew Berchuck, and Stephanie Gaillard. “Abstract 4570: Role of ERRalpha in ovarian cancer.” In Cancer Research, 74:4570–4570. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1538-7445.am2014-4570.Full Text
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Katzenellenbogen, John A., Julie A. Pollock, Alexander A. Parent, Suzanne Elizabeth Wardell, Donald P. McDonnell, and John D. Norris. “Structurally Novel Antagonists of Androgen Receptors with Elevated Potency for Antiandrogen-Resistant Receptor Mutants in Prostate Cancer: Tetra-Aryl-Substituted Cyclobutanes.” In Endocrine Reviews, Vol. 35. ENDOCRINE SOC, 2014.Link to Item
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Katzenellenbogen, John A., Julie A. Pollock, Alexander A. Parent, Suzanne Elizabeth Wardell, Donald P. McDonnell, and John D. Norris. “Structurally Novel Antagonists of Androgen Receptors with Elevated Potency for Antiandrogen-Resistant Receptor Mutants in Prostate Cancer: Tetra-Aryl-Substituted Cyclobutanes.” In Endocrine Reviews, Vol. 35. ENDOCRINE SOC, 2014.Link to Item
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Pollock, Julie A., Michelle D. Larrea, Donald P. McDonnell, and Dewey G. McCafferty. “Examination of the effects of small molecule inhibitors of human histone lysine-specific demethylase I in breast cancer cells.” In Abstracts of Papers of the American Chemical Society, Vol. 241. AMER CHEMICAL SOC, 2011.Link to Item
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Yang, J., C. D. Clyne, R. Safi, C. Y. Chang, P. J. Fuller, D. P. McDonnell, and M. J. Young. “The Mineralocorticoid Receptor: Exploring Ligand-Specificity Using Peptide Phage Display.” In Endocrine Reviews, Vol. 31. ENDOCRINE SOC, 2010.Link to Item
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Dwyer, M., D. P. McDonnell, P. Hu, S. Cousins, and G. Malek. “Oxidant Activation of the Transcription Factor Aryl Hydrocarbon Receptor Effects Mitochondrial Function in Retinal Pigment Epithelial Cells.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.Link to Item
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Malek, G., P. Hu, M. Dwyer, S. W. Cousins, and D. P. McDonnell. “Expression Profiling of Nuclear Receptors in Human Retinal Pigment Epithelial Cells: Relevance to Age-Related Macular Degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.Link to Item
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McDonnell, Donald P. “Definition of Functionally Important Mechanistic Differences among Selective Estrogen Receptor Modulators.” In Menopause the Journal of the North American Menopause Society, 15:1199–1199. LIPPINCOTT WILLIAMS & WILKINS, 2008.Link to Item
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McDonnell, D. P. “SARMS, SERMS, SGRM.” In Osteoporosis International, 17:S128–S128. SPRINGER LONDON LTD, 2006.Link to Item
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McDonnell, D. P. “The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer.” In Clinical Cancer Research, 11:871S-877S. AMER ASSOC CANCER RESEARCH, 2005.Link to Item
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Simpson, E. R., D. P. McDonnell, A. Kovacic, C. D. Clyne, and R. Safi. “Regulation of aromatase expression in the breast by LRH-1: a new potential target for breast cancer therapy.” In Breast Cancer Research and Treatment, 94:S236–S236. SPRINGER, 2005.Link to Item
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McDonnell, D. P. “Progesterone, estrogen and androgen receptor signaling pathways are complex and provide a wealth of opportunities for new drug discovery.” In Abstracts of Papers of the American Chemical Society, 227:U45–U45. AMER CHEMICAL SOC, 2004.Link to Item
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McDonnell, D. P. “Mining the complexities of nuclear receptor signaling for new drug targets.” In Biology of Reproduction, 81–81. SOC STUDY REPRODUCTION, 2004.Link to Item
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Blackwell, K. L., M. W. Dewhirst, D. P. McDonnell, H. Dressman, S. A. Snyder, and J. R. Marks. “MTA-1 (metastasis associated protein-1) is upregulated in tamoxifen-resistant breast cancer.” In Breast Cancer Research and Treatment, 82:S88–S88. KLUWER ACADEMIC PUBL, 2003.Link to Item
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Chang, C. Y., M. Jansen, G. Sathya, and D. P. McDonnell. “Aromasin and its 17-hydro metabolite manifest androgenic activity which may be responsible for its bone protective effect.” In Breast Cancer Research and Treatment, 82:S103–S103. KLUWER ACADEMIC PUBL, 2003.Link to Item
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McDonnell, Donald P. “Selective Estrogen Receptor Modulators (SERMs): A First Step in the Development of Perfect Hormone Replacement Therapy Regimen.” In Journal of the Society for Gynecologic Investigation, 7:S10–15. Springer Science and Business Media LLC, 2000. https://doi.org/10.1177/1071557600007001s05.Full Text
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McDonnell, D. P., B. A. Lieberman, and J. Norris. “Development of tissue-selective estrogen receptor modulators.” In Organ Selective Actions of Steroid Hormones, edited by D. T. Baird, G. Schutz, and R. Krattenmacher, 16:1–28. SPRINGER-VERLAG BERLIN, 1995.Link to Item
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