Donald Patrick McDonnell

Donald Patrick McDonnell
Chair, Department of Pharmacology & Cancer Biology

The research in our group is focused on the development and application of mechanism based approaches to identify novel therapeutics for use in the treatment and prevention of hormonally responsive cancers. Specifically we are interested in the pharmaceutical exploitation of the estrogen and androgen receptors as therapeutic targets in breast and prostate cancers and in defining how these receptors influence the pathogenesis of these diseases. These efforts have led to the discovery of several drugs that are currently being evaluated in the clinic as cancer therapeutics, and to the identification of potential biomarkers and predictors of response that can help to target the use of these new drugs. Most recently we have explored approaches to treat triple negative breast cancer and have identified an important pathway that links obesity/dyslipidemia and cancer risk.

Current Appointments & Affiliations

Chair, Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011
Glaxo-Wellcome Professor of Molecular Cancer Biology, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2002
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2000
Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1994
Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Institutes and Provost's Academic Units 2018

Contact Information

C238A Lev Sci Res Ctr, Durham, NC 27708
Duke Box 3813, Durham, NC 27710
donald.mcdonnell@duke.edu (919) 684-6035

Background
Education, Training, & Certifications
- Ph.D., Baylor College of Medicine 1988
Duke Appointment History
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1997 - 2000
- Associate Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 1997
Recognition
In the News
- MAY 3, 2018 Duke Magazine
  
  The Campus Lab That Makes and Sells Molecules
- FEB 21, 2017 Duke Health News
  
  Prostate Cancer Cells Grow with Malfunction of Cholesterol Control in Cells
- OCT 15, 2014
  
  Prostate Cancer's Penchant for Copper May Be A Fatal Flaw
- DEC 3, 2013
  
  High Cholesterol's Link to Breast Cancer
- DEC 2, 2013 BBC News
  
  Cholesterol 'fuels' breast cancer
- DEC 2, 2013 The News & Observer
  
  Duke study: Many breast cancers may be linked with cholesterol byproduct
- DEC 2, 2013
  
  High Cholesterol Fuels the Growth and Spread of Breast Cancer
- AUG 1, 2013 WRAL.com
  
  Komen grants $3.6 million to Duke, UNC breast cancer research
- JUN 28, 2013 Fox News
  
  Osteoporosis drug blocks growth of breast cancer cells
- JUN 18, 2013
  
  Osteoporosis Drug Stops Growth of Breast Cancer Cells, Even in Resistant Tumors
- JUN 17, 2013 London Daily Express
  
  Brittle bone drug can fight off breast cancer
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2022
- Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors awarded by Department of Defense 2018 - 2022
- Defining the Rules of Breast Cancer Cell Traffic Through Bone awarded by National Institutes of Health 2017 - 2021
- Identification of actionable networks promoting breast cancer progression and brain metastasis awarded by Department of Defense 2018 - 2021
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- The Role of Epigenetic Plasticity in Breast Cancer Recurrence awarded by National Institutes of Health 2018 - 2021
- Identification of Novel Targets in Treatment Resistant Prostate Cancer awarded by Celgene Corporation 2017 - 2020
- Immune modulation of CaMKK2 in the ovarian tumor microenvironment awarded by American Association of Obstetricians and Gynecologists Foundation 2019 - 2020
- RIP140 as a mediator of Estrogen Receptor action in tumor associated macrophages awarded by National Institutes of Health 2017 - 2020
- Targeting the GRHL2/AGR2/LYPD3 axis in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2018 - 2020
- Targeting precursor neural (N)-cadherin to eliminate chemotherapy-resistant triple-negative breast tumor cells awarded by Department of Defense 2017 - 2020
- Role of Cholesterol Efflux Blockade in Mycobacterial Infection In Vivo awarded by National Institutes of Health 2017 - 2020
- ER and LXR as mediators of the pathobiology of hypercholesterolemia awarded by National Institutes of Health 1997 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Hypercholesterolemia as a modifier of the tumor microenvironment in breast cancer awarded by Department of Defense 2016 - 2019
- Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
- Developing in vivo active probes for CAMKK2 to treat cancer awarded by University of North Carolina - Chapel Hill 2017 - 2019
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
- Effects of dietary methionine restriction on tumor growth and epigenetics awarded by American Cancer Society, Inc. 2018
- Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- Development of mechanistically distinct androgen receptor antagonists and degraders for the treatment of advanced castra awarded by Department of Defense 2015 - 2018
- A Novel Function for ALK4 in Suppressing Breast Cancer Progression awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- Developing small-molecule probes for protein arginine methyltransferases awarded by National Institutes of Health 2015 - 2018
- Seahorse XFe96 Extracellular Flux Analyzer awarded by North Carolina Biotechnology Center 2017 - 2018
- Targeting the synthetic essential kinases of breast cancers awarded by Department of Defense 2015 - 2018
- Optimization of ERalpa-LBD-based CAR-T switch awarded by Cell Design Labs, Inc 2017 - 2018
- The role of ERRalpha/PGC-1 in disease pathogenesis awarded by National Institutes of Health 2006 - 2018
- CaMKK2: a druggable target that regulates macrophage function in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2013 - 2017
- Control of the apoptosome in epithelial ovarian cancer to enhance chemotherapy awarded by National Institutes of Health 2014 - 2017
- Evaluation of the therapeutic potential of combining VT464 and G1T38 in treatment-resistant prostate and breast cancer models awarded by Innocrin Pharmaceutical, Inc. 2016 - 2017
- Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis awarded by National Institutes of Health 2011 - 2017
- Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration awarded by National Institutes of Health 2011 - 2017
- Metabolism of Effector T cells as a Target in SLE awarded by Vanderbilt University 2015 - 2017
- BC123577: Targeting Epigenetics Therapy for Estrogen Receptor Negative Breast Cancers awarded by United States Army Medical Research and Materiel Command 2013 - 2016
- Targeting the CDK 4/6 axis in Castration Resistant Prostate Cancer awarded by G1 Therapeutics Inc. 2015 - 2016
- Targeting aerobic glycolysis in T-ALL awarded by National Institutes of Health 2014 - 2016
- Identification of a novel target for treating breast cancer metastasis awarded by American Cancer Society, Inc. 2014 - 2016
- Evaluation of VT-464 in AR positive and ER positive breast cancer models awarded by Innocrin Pharmaceutical, Inc. 2015 - 2016
- Androgen receptor degradation as a therapeutic modality in castrate resistant prostate cancer awarded by Arvinas Inc. 2015
- T cell metabolism as a determinant of differentiation in allergic asthma awarded by National Institutes of Health 2011 - 2015
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Determination of the antiandrogenic properties of VT-464, a novel CYP17 lyase inhibitor awarded by Viamet Pharmaceuticals 2014 - 2015
- B cell metabolism in activation and autoantibody production awarded by National Institutes of Health 2013 - 2015
- Molecular pharmacology of bazedoxifene and pipendoxifene in breast cancer awarded by Pfizer, Inc. 2013 - 2014
- 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis awarded by National Institutes of Health 2013 - 2014
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- Molecular Determinants of Androgen Receptor Pharmacology awarded by National Institutes of Health 2003 - 2013
- Nonclassical signaling of the androgen receptor polyproline domain awarded by National Institutes of Health 2009 - 2010
- G Protein Involvement in Oncogenesis and Metastasis awarded by National Institutes of Health 2004 - 2009
- Integrated instrument systems for maintenance and delivery of RNAi libraries awarded by National Institutes of Health 2008 - 2009
- The Androgen Receptor: Cofactor Interface awarded by National Institutes of Health 2002 - 2005
- Development and Use of Systems to Study Estrogen Action awarded by National Institutes of Health 2002
- RAR-Beta Mediated Apoptosis in Breast Cancer Cells awarded by National Institutes of Health 1995 - 2000
Publications & Artistic Works
Selected Publications
- Book Sections
  - Grasfeder, LL, and McDonnell, DP. "Nuclear receptor cofactor interactions as targets for new drug discovery." In NR Coregulators and Human Diseases, 572-599. January 1, 2008. Full Text
- Conference Papers
  - Kimbung, S, Chang, C-Y, Bendahl, P-O, Dubois, L, Thompson, WJ, McDonnell, DP, and Borgquist, S. "Impact of the sterol 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol on tumor-pathological features, prognosis and response to statin treatment in breast cancer." May 2017. Link to Item
  - Quayle, L, Park, S, McDonnell, D, Ottewell, P, and Holen, I. "Abstract P3-07-14: Targeting ERR-α regulated lactate metabolism eliminates drug-resistant breast cancer cells." February 15, 2017. Full Text
  - Alfaqih, M, Nelson, E, Liu, W, Safi, R, Jasper, J, Macias, E, Geradts, J, Chang, C, McDonnell, D, and Freedland, S. "CYP27A1/27HC/SREBP2 axis is a novel therapeutic target in prostate cancer." December 2016. Full Text
  - Ellison, S, Norris, J, Wardell, S, Eisner, J, Hoekstra, W, Stagg, D, Alley, H, Moore, W, and McDonnell, D. "Abstract P3-14-04: Effects of the dual selective CYP17 lyase inhibitor and androgen receptor (AR) antagonist, VT-464, on AR+ and ER+ tumor models in vitro and in vivo." February 15, 2016. Full Text
  - Alwarawrah, Y, Hughes, P, Safi, R, McDonnell, DP, Spector, NL, and Haystead, TA. "Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106." August 1, 2015. Full Text
  - Moore, WR, Norris, JD, Wardell, S, Eisner, JR, Hoekstra, WJ, Schotzinger, RJ, and McDonnell, DP. "Direct effects of the selective CYP17 lyase (L) inhibitor, VT-464, on the androgen receptor (AR) and its oral activity in an F876L tumor mouse xenograft model." March 2015. Full Text
  - Alfaqih, MA, Nelson, ER, Safi, R, Jasper, J, Chang, C-Y, Freedland, SJ, and McDonnell, DP. "Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer." October 1, 2014. Full Text
  - Stevens, EV, Whitaker, R, Guinet, A, Chang, C-Y, Grenier, C, Marks, J, McDonnell, DP, Murphy, SK, Berchuck, A, and Gaillard, S. "Abstract 4570: Role of ERRalpha in ovarian cancer." October 1, 2014. Full Text
  - Katzenellenbogen, JA, Pollock, JA, Parent, AA, Wardell, SE, McDonnell, DP, and Norris, JD. "Structurally Novel Antagonists of Androgen Receptors with Elevated Potency for Antiandrogen-Resistant Receptor Mutants in Prostate Cancer: Tetra-Aryl-Substituted Cyclobutanes." June 2014. Link to Item
  - Katzenellenbogen, JA, Pollock, JA, Parent, AA, Wardell, SE, McDonnell, DP, and Norris, JD. "Structurally Novel Antagonists of Androgen Receptors with Elevated Potency for Antiandrogen-Resistant Receptor Mutants in Prostate Cancer: Tetra-Aryl-Substituted Cyclobutanes." June 2014. Link to Item
  - Pollock, JA, Larrea, MD, McDonnell, DP, and McCafferty, DG. "Examination of the effects of small molecule inhibitors of human histone lysine-specific demethylase I in breast cancer cells." March 27, 2011. Link to Item
  - Yang, J, Clyne, CD, Safi, R, Chang, CY, Fuller, PJ, McDonnell, DP, and Young, MJ. "The Mineralocorticoid Receptor: Exploring Ligand-Specificity Using Peptide Phage Display." June 2010. Link to Item
  - Dwyer, M, McDonnell, DP, Hu, P, Cousins, S, and Malek, G. "Oxidant Activation of the Transcription Factor Aryl Hydrocarbon Receptor Effects Mitochondrial Function in Retinal Pigment Epithelial Cells." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010. Link to Item
  - Malek, G, Hu, P, Dwyer, M, Cousins, SW, and McDonnell, DP. "Expression Profiling of Nuclear Receptors in Human Retinal Pigment Epithelial Cells: Relevance to Age-Related Macular Degeneration." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010. Link to Item
  - McDonnell, DP. "Definition of Functionally Important Mechanistic Differences among Selective Estrogen Receptor Modulators." 2008. Link to Item
  - McDonnell, DP. "SARMS, SERMS, SGRM." May 2006. Link to Item
  - McDonnell, DP. "The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer." January 15, 2005. Link to Item
  - Simpson, ER, McDonnell, DP, Kovacic, A, Clyne, CD, and Safi, R. "Regulation of aromatase expression in the breast by LRH-1: a new potential target for breast cancer therapy." 2005. Link to Item
  - McDonnell, DP. "Progesterone, estrogen and androgen receptor signaling pathways are complex and provide a wealth of opportunities for new drug discovery." March 28, 2004. Link to Item
  - McDonnell, DP. "Mining the complexities of nuclear receptor signaling for new drug targets." 2004. Link to Item
  - Blackwell, KL, Dewhirst, MW, McDonnell, DP, Dressman, H, Snyder, SA, and Marks, JR. "MTA-1 (metastasis associated protein-1) is upregulated in tamoxifen-resistant breast cancer." 2003. Link to Item
  - Chang, CY, Jansen, M, Sathya, G, and McDonnell, DP. "Aromasin and its 17-hydro metabolite manifest androgenic activity which may be responsible for its bone protective effect." 2003. Link to Item
  - McDonnell, DP. "Selective Estrogen Receptor Modulators (SERMs): A First Step in the Development of Perfect Hormone Replacement Therapy Regimen." January 2000. Full Text
  - McDonnell, DP, Lieberman, BA, and Norris, J. "Development of tissue-selective estrogen receptor modulators." 1995. Link to Item
- Journal Articles
  - Chang, P-Y, Feldman, D, Stefanick, ML, McDonnell, DP, Thompson, BM, McDonald, JG, and Lee, JS. "27-hydroxycholesterol, an endogenous SERM, and risk of fracture in postmenopausal women: A nested case-cohort study in the Women's Health Initiative." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research (August 23, 2018). Full Text
  - Singh, BK, Sinha, RA, Tripathi, M, Mendoza, A, Ohba, K, Sy, JAC, Xie, SY, Zhou, J, Ho, JP, Chang, C-Y, Wu, Y, Giguère, V, Bay, B-H, Vanacker, J-M, Ghosh, S, Gauthier, K, Hollenberg, AN, McDonnell, DP, and Yen, PM. "Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function." Science Signaling 11, no. 536 (June 26, 2018). Full Text
  - Anderson, GR, Wardell, SE, Cakir, M, Yip, C, Ahn, Y-R, Ali, M, Yllanes, AP, Chao, CA, McDonnell, DP, and Wood, KC. "Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors." Nature Communications 9, no. 1 (April 26, 2018): 1677-null. Full Text
  - Tria, GS, Abrams, T, Baird, J, Burks, HE, Firestone, B, Gaither, LA, Hamann, LG, He, G, Kirby, CA, Kim, S, Lombardo, F, Macchi, KJ, McDonnell, DP, Mishina, Y, Norris, JD, Nunez, J, Springer, C, Sun, Y, Thomsen, NM, Wang, C, Wang, J, Yu, B, Tiong-Yip, C-L, and Peukert, S. "Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer." Journal of medicinal chemistry (March 22, 2018). Full Text
  - McLeod, AB, Stice, JP, Wardell, SE, Alley, HM, Chang, C-Y, and McDonnell, DP. "Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer." The Prostate 78, no. 4 (March 2018): 266-277. Full Text
  - McDonnell, DP, Norris, JD, and Chang, C-Y. "Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery." Cancer Cell 33, no. 2 (February 2018): 153-155. Full Text Open Access Copy
  - Salami, J, Alabi, S, Willard, RR, Vitale, NJ, Wang, J, Dong, H, Jin, M, McDonnell, DP, Crew, AP, Neklesa, TK, and Crews, CM. "Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance." Communications Biology 1 (January 2018): 100-null. Full Text
  - Baek, AE, Yu, Y-RA, He, S, Wardell, SE, Chang, C-Y, Kwon, S, Pillai, RV, McDowell, HB, Thompson, JW, Dubois, LG, Sullivan, PM, Kemper, JK, Gunn, MD, McDonnell, DP, and Nelson, ER. "The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells." Nature Communications 8, no. 1 (October 11, 2017): 864-null. Full Text
  - Coons, LA, Hewitt, SC, Burkholder, AB, McDonnell, DP, and Korach, KS. "DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin." Endocrinology 158, no. 10 (October 2017): 3212-3234. Full Text
  - Liberti, MV, Dai, Z, Wardell, SE, Baccile, JA, Liu, X, Gao, X, Baldi, R, Mehrmohamadi, M, Johnson, MO, Madhukar, NS, Shestov, AA, Chio, IIC, Elemento, O, Rathmell, JC, Schroeder, FC, McDonnell, DP, and Locasale, JW. "A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product." Cell Metabolism 26, no. 4 (October 2017): 648-659.e8. Full Text
  - Kimbung, S, Chang, C-Y, Bendahl, P-O, Dubois, L, Thompson, JW, McDonnell, DP, and Borgquist, S. "Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer." Endocrine-related cancer 24, no. 7 (July 2017): 339-349. Full Text
  - Tang, X, Ding, C-K, Wu, J, Sjol, J, Wardell, S, Spasojevic, I, George, D, McDonnell, DP, Hsu, DS, Chang, JT, and Chi, J-T. "Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling." Oncogene 36, no. 30 (July 2017): 4235-4242. Full Text
  - Norris, JD, Ellison, SJ, Baker, JG, Stagg, DB, Wardell, SE, Park, S, Alley, HM, Baldi, RM, Yllanes, A, Andreano, KJ, Stice, JP, Lawrence, SA, Eisner, JR, Price, DK, Moore, WR, Figg, WD, and McDonnell, DP. "Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer." The Journal of Clinical Investigation 127, no. 6 (June 2017): 2326-2338. Full Text
  - Stice, JP, Wardell, SE, Norris, JD, Yllanes, AP, Alley, HM, Haney, VO, White, HS, Safi, R, Winter, PS, Cocce, KJ, Kishton, RJ, Lawrence, SA, Strum, JC, and McDonnell, DP. "CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC." Molecular cancer research : MCR 15, no. 6 (June 2017): 660-669. Full Text
  - Alfaqih, MA, Nelson, ER, Liu, W, Safi, R, Jasper, JS, Macias, E, Geradts, J, Thompson, JW, Dubois, LG, Freeman, MR, Chang, C-Y, Chi, J-T, McDonnell, DP, and Freedland, SJ. "CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer." Cancer Research 77, no. 7 (April 2017): 1662-1673. Full Text
  - Burks, HE, Abrams, T, Kirby, CA, Baird, J, Fekete, A, Hamann, LG, Kim, S, Lombardo, F, Loo, A, Lubicka, D, Macchi, K, McDonnell, DP, Mishina, Y, Norris, JD, Nunez, J, Saran, C, Sun, Y, Thomsen, NM, Wang, C, Wang, J, and Peukert, S. "Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer." Journal of Medicinal Chemistry 60, no. 7 (April 2017): 2790-2818. Full Text
  - Christenson, JL, Butterfield, KT, Spoelstra, NS, Norris, JD, Josan, JS, Pollock, JA, McDonnell, DP, Katzenellenbogen, BS, Katzenellenbogen, JA, and Richer, JK. "MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression." Hormones & Cancer 8, no. 2 (April 2017): 69-77. Full Text
  - Alexander, PB, Chen, R, Gong, C, Yuan, L, Jasper, JS, Ding, Y, Markowitz, GJ, Yang, P, Xu, X, McDonnell, DP, Song, E, and Wang, X-F. "Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer." The Journal of Biological Chemistry 292, no. 2 (January 2017): 748-759. Full Text Open Access Copy
  - Anderson, GR, Wardell, SE, Cakir, M, Crawford, L, Leeds, JC, Nussbaum, DP, Shankar, PS, Soderquist, RS, Stein, EM, Tingley, JP, Winter, PS, Zieser-Misenheimer, EK, Alley, HM, Yllanes, A, Haney, V, Blackwell, KL, McCall, SJ, McDonnell, DP, and Wood, KC. "PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation." Science Translational Medicine 8, no. 369 (December 2016): 369ra175-null. Full Text Open Access Copy
  - Nelson, ER, Li, S, Kennedy, M, Payne, S, Kilibarda, K, Groth, J, Bowie, M, Parilla-Castellar, E, de Ridder, G, Marcom, PK, Lyes, M, Peterson, BL, Cook, M, Pizzo, SV, McDonnell, DP, and Bachelder, RE. "Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface." Oncotarget 7, no. 51 (December 2016): 84030-84042. Full Text
  - Pollock, JA, Wardell, SE, Parent, AA, Stagg, DB, Ellison, SJ, Alley, HM, Chao, CA, Lawrence, SA, Stice, JP, Spasojevic, I, Baker, JG, Kim, SH, McDonnell, DP, Katzenellenbogen, JA, and Norris, JD. "Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer." Nature Chemical Biology 12, no. 10 (October 2016): 795-801. Full Text
  - Wood, KC, Anderson, GR, Wardell, SE, Jasper, JS, Stein, EM, Martz, CA, Alley, HM, Haney, V, Yllanes, A, Blackwell, KL, McCall, SJ, and McDonnell, DP. "Identification and Therapeutic Inhibition of Pathways Driving Resistance to Targeted Breast Cancer Therapies." JOURNAL OF WOMENS HEALTH 25, no. 9 (September 2016): 976-976. Link to Item
  - Park, S, Chang, C-Y, Safi, R, Liu, X, Baldi, R, Jasper, JS, Anderson, GR, Liu, T, Rathmell, JC, Dewhirst, MW, Wood, KC, Locasale, JW, and McDonnell, DP. "ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer." Cell Reports 15, no. 2 (April 2016): 323-335. Full Text
  - Xu, X, Zhang, Y, Jasper, J, Lykken, E, Alexander, PB, Markowitz, GJ, McDonnell, DP, Li, Q-J, and Wang, X-F. "MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer." Oncotarget 7, no. 15 (April 2016): 20381-20394. Full Text
  - Wardell, SE, Ellis, MJ, Alley, HM, Eisele, K, VanArsdale, T, Dann, SG, Arndt, KT, Primeau, T, Griffin, E, Shao, J, Crowder, R, Lai, J-P, Norris, JD, McDonnell, DP, and Li, S. "Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 21, no. 22 (November 2015): 5121-5130. Full Text
  - Blessing, AM, Ganesan, S, Rajapakshe, K, Ying Sung, Y, Reddy Bollu, L, Shi, Y, Cheung, E, Coarfa, C, Chang, JT, McDonnell, DP, and Frigo, DE. "Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus." Molecular endocrinology (Baltimore, Md.) 29, no. 10 (October 2015): 1426-1439. Full Text
  - Wardell, SE, Nelson, ER, Chao, CA, Alley, HM, and McDonnell, DP. "Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader." Endocrine Related Cancer 22, no. 5 (October 2015): 713-724. Full Text
  - Gustafson, JL, Neklesa, TK, Cox, CS, Roth, AG, Buckley, DL, Tae, HS, Sundberg, TB, Stagg, DB, Hines, J, McDonnell, DP, Norris, JD, and Crews, CM. "Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging." Angewandte Chemie (International Ed. in English) 54, no. 33 (August 2015): 9659-9662. Full Text
  - Gustafson, JL, Neklesa, TK, Cox, CS, Roth, AG, Buckley, DL, Tae, HS, Sundberg, TB, Stagg, DB, Hines, J, McDonnell, DP, Norris, JD, and Crews, CM. "Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging." Angewandte Chemie International Edition 54, no. 33 (August 1, 2015): 9659-9662. Full Text
  - Lontay, B, Bodoor, K, Sipos, A, Weitzel, DH, Loiselle, D, Safi, R, Zheng, D, Devente, J, Hickner, RC, McDonnell, DP, Ribar, T, and Haystead, TA. "Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice." The Journal of Biological Chemistry 290, no. 29 (July 2015): 17985-17998. Full Text
  - McDonnell, DP, Wardell, SE, and Norris, JD. "Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer." Journal of Medicinal Chemistry 58, no. 12 (June 3, 2015): 4883-4887. Full Text
  - Allensworth, JL, Evans, MK, Bertucci, F, Aldrich, AJ, Festa, RA, Finetti, P, Ueno, NT, Safi, R, McDonnell, DP, Thiele, DJ, Van Laere, S, and Devi, GR. "Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer." Molecular oncology 9, no. 6 (June 2015): 1155-1168. Full Text
  - Allensworth, JL, Evans, MK, Bertucci, F, Aldrich, AJ, Festa, RA, Finetti, P, Ueno, NT, Safi, R, McDonnell, DP, Thiele, DJ, Van Laere, S, and Devi, GR. "Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer." Molecular Oncology 9, no. 6 (January 1, 2015): 1155-1168. Full Text
  - Choudhary, M, Kazmin, D, Hu, P, Thomas, RS, McDonnell, DP, and Malek, G. "Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways." The Journal of Pathology 235, no. 1 (January 2015): 101-112. Full Text
  - Martz, CA, Ottina, KA, Singleton, KR, Jasper, JS, Wardell, SE, Peraza-Penton, A, Anderson, GR, Winter, PS, Wang, T, Alley, HM, Kwong, LN, Cooper, ZA, Tetzlaff, M, Chen, P-L, Rathmell, JC, Flaherty, KT, Wargo, JA, McDonnell, DP, Sabatini, DM, and Wood, KC. "Systematic identification of signaling pathways with potential to confer anticancer drug resistance." Science Signaling 7, no. 357 (December 23, 2014): ra121-null. Full Text
  - McDonnell, DP, Chang, C-Y, and Nelson, ER. "The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer." Climacteric : the Journal of the International Menopause Society 17 Suppl 2 (December 2014): 60-65. Full Text
  - Nelson, ER, Chang, C-Y, and McDonnell, DP. "Cholesterol and breast cancer pathophysiology." Trends in Endocrinology and Metabolism: Tem 25, no. 12 (December 2014): 649-655. (Review) Full Text
  - Wright, TM, Wardell, SE, Jasper, JS, Stice, JP, Safi, R, Nelson, ER, and McDonnell, DP. "Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer." Molecular Cancer Research : Mcr 12, no. 12 (December 2014): 1829-1839. Full Text
  - Wardell, SE, Nelson, ER, and McDonnell, DP. "From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)." Steroids 90 (November 15, 2014): 30-38. Full Text
  - Wardell, SE, Nelson, ER, and McDonnell, DP. "From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)." Steroids 90 (November 2014): 30-38. Full Text
  - Gustafsson, J-A, Katzenellenbogen, B, Jameson, JL, Roth, J, Melmed, S, McDonnell, D, Wartofsky, L, Crowley, WF, Griz, LH, Becker, C, Moore, DD, Drucker, D, Singh, N, and O'Malley, B. "Endocrine Society 2014 Laureate Awards." Hormones & cancer 5, no. 5 (October 2014): 339-355. Full Text
  - Safi, R, Nelson, ER, Chitneni, SK, Franz, KJ, George, DJ, Zalutsky, MR, and McDonnell, DP. "Copper signaling axis as a target for prostate cancer therapeutics." Cancer Research 74, no. 20 (October 2014): 5819-5831. Full Text Open Access Copy
  - McDonnell, DP, Park, S, Goulet, MT, Jasper, J, Wardell, SE, Chang, C-Y, Norris, JD, Guyton, JR, and Nelson, ER. "Obesity, cholesterol metabolism, and breast cancer pathogenesis." Cancer Research 74, no. 18 (September 2014): 4976-4982. Full Text
  - Yang, J, Fuller, PJ, Morgan, J, Shibata, H, McDonnell, DP, Clyne, CD, and Young, MJ. "Use of phage display to identify novel mineralocorticoid receptor-interacting proteins." Molecular endocrinology (Baltimore, Md.) 28, no. 9 (September 2014): 1571-1584. Full Text
  - Stossi, F, Bolt, MJ, Dandekar, RD, Putluri, V, Kaushik, AK, Chang, C-Y, Mancini, MM, Sreekumar, A, McDonnell, DP, and Mancini, MA. "Bisphenol AP Is a Novel AR Down-Regulator in Castrate Resistant Prostate Cancer Cells Via Modulation of Nuclear Receptors' Networks." ENDOCRINE REVIEWS 35, no. 3 (June 2014). Link to Item
  - Scholtz, EL, Krishnan, S, Ball, BA, Corbin, CJ, Moeller, BC, Stanley, SD, McDowell, KJ, Hughes, AL, McDonnell, DP, and Conley, AJ. "Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone." Proceedings of the National Academy of Sciences of the United States of America 111, no. 9 (March 2014): 3365-3370. Full Text
  - Shatnawi, A, Norris, JD, Chaveroux, C, Jasper, JS, Sherk, AB, McDonnell, DP, and Giguère, V. "ELF3 is a repressor of androgen receptor action in prostate cancer cells." Oncogene 33, no. 7 (February 13, 2014): 862-871. Full Text
  - Shatnawi, A, Norris, JD, Chaveroux, C, Jasper, JS, Sherk, AB, McDonnell, DP, and Giguère, V. "ELF3 is a repressor of androgen receptor action in prostate cancer cells." Oncogene 33, no. 7 (February 2014): 862-871. Full Text
  - Weiser, PT, Chang, C-Y, McDonnell, DP, and Hanson, RN. "4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors." Bioorg Med Chem 22, no. 2 (January 15, 2014): 917-926. Full Text Link to Item
  - Weiser, PT, Chang, CY, McDonnell, DP, and Hanson, RN. "4,4′-Unsymmetrically substituted 3,3′-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors." Bioorganic and Medicinal Chemistry 22, no. 2 (January 15, 2014): 917-926. Full Text
  - Nelson, ER, Chang, CY, and McDonnell, DP. "Cholesterol and breast cancer pathophysiology." Trends in Endocrinology and Metabolism 25, no. 12 (January 1, 2014): 649-655. (Review) Full Text
  - Nelson, ER, Wardell, SE, Jasper, JS, Park, S, Suchindran, S, Howe, MK, Carver, NJ, Pillai, RV, Sullivan, PM, Sondhi, V, Umetani, M, Geradts, J, and McDonnell, DP. "27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology." Science (New York, N.Y.) 342, no. 6162 (November 2013): 1094-1098. Full Text
  - Hu, P, Herrmann, R, Bednar, A, Saloupis, P, Dwyer, MA, Yang, P, Qi, X, Thomas, RS, Jaffe, GJ, Boulton, ME, McDonnell, DP, and Malek, G. "Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology." Proceedings of the National Academy of Sciences of the United States of America 110, no. 43 (October 8, 2013): E4069-E4078. Full Text
  - Wardell, SE, Nelson, ER, Chao, CA, and McDonnell, DP. "Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 19, no. 9 (May 2013): 2420-2431. Full Text
  - Nelson, ER, Wardell, SE, and McDonnell, DP. "The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis." Bone 53, no. 1 (March 2013): 42-50. (Review) Full Text Link to Item
  - Nelson, ER, Wardell, SE, Howe, MK, Carver, NJ, Umetani, M, and McDonnell, DP. "Abstract PR3: The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis." Cancer Research 73, no. 3 Supplement (February 1, 2013): PR3-PR3. Full Text
  - Shi, Y, Han, JJ, Tennakoon, JB, Mehta, FF, Merchant, FA, Burns, AR, Howe, MK, McDonnell, DP, and Frigo, DE. "Androgens promote prostate cancer cell growth through induction of autophagy." Molecular Endocrinology (Baltimore, Md.) 27, no. 2 (February 2013): 280-295. Full Text
  - Augello, MA, Burd, CJ, Birbe, R, McNair, C, Ertel, A, Magee, MS, Frigo, DE, Wilder-Romans, K, Shilkrut, M, Han, S, Jernigan, DL, Dean, JL, Fatatis, A, McDonnell, DP, Visakorpi, T, Feng, FY, and Knudsen, KE. "Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes." The Journal of Clinical Investigation 123, no. 1 (January 2013): 493-508. Full Text
  - Wardell, SE, McDonnell, DP, and Nelson, ER. "Regulation of Bone Cell Function by Estrogens." (January 1, 2013): 329-344. (Chapter) Full Text
  - Chang, C-Y, and McDonnell, DP. "Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 18, no. 22 (November 2012): 6089-6095. Full Text
  - Pollock, JA, Larrea, MD, Jasper, JS, McDonnell, DP, and McCafferty, DG. "Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners." ACS Chem Biol 7, no. 7 (July 20, 2012): 1221-1231. Full Text Link to Item
  - Wardell, SE, Kazmin, D, and McDonnell, DP. "Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes." Molecular Endocrinology (Baltimore, Md.) 26, no. 7 (July 2012): 1235-1248. Full Text
  - Malek, G, Dwyer, M, and McDonnell, D. "Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD." Advances in Experimental Medicine and Biology 723 (January 2012): 51-59. (Review) Full Text
  - Weiser, PT, Williams, AB, Chang, C-Y, McDonnell, DP, and Hanson, RN. "3,3′-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding." Bioorganic and Medicinal Chemistry Letters 22, no. 21 (2012): 6587-6590. Full Text
  - Nelson, ER, DuSell, CD, Wang, X, Howe, MK, Evans, G, Michalek, RD, Umetani, M, Rathmell, JC, Khosla, S, Gesty-Palmer, D, and McDonnell, DP. "The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors." Endocrinology 152, no. 12 (December 2011): 4691-4705. Full Text Link to Item
  - Michalek, RD, Gerriets, VA, Nichols, AG, Inoue, M, Kazmin, D, Chang, C-Y, Dwyer, MA, Nelson, ER, Pollizzi, KN, Ilkayeva, O, Giguere, V, Zuercher, WJ, Powell, JD, Shinohara, ML, McDonnell, DP, and Rathmell, JC. "Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation." Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18348-18353. Full Text Link to Item
  - Chang, C-Y, Kazmin, D, Jasper, JS, Kunder, R, Zuercher, WJ, and McDonnell, DP. "The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer." Cancer Cell 20, no. 4 (October 2011): 500-510. Full Text
  - Bodoor, K, Lontay, B, Safi, R, Weitzel, DH, Loiselle, D, Wei, Z, Lengyel, S, McDonnell, DP, and Haystead, TA. "Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy." The Journal of Biological Chemistry 286, no. 36 (September 2011): 31839-31851. Full Text
  - Wardell, SE, Marks, JR, and McDonnell, DP. "The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy." Biochemical Pharmacology 82, no. 2 (July 2011): 122-130. Full Text
  - Dwyer, MA, Kazmin, D, Hu, P, McDonnell, DP, and Malek, G. "Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration." Molecular Endocrinology (Baltimore, Md.) 25, no. 2 (February 2011): 360-372. Full Text
  - Frigo, DE, Howe, MK, Wittmann, BM, Brunner, AM, Cushman, I, Wang, Q, Brown, M, Means, AR, and McDonnell, DP. "CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells." Cancer Research 71, no. 2 (January 2011): 528-537. Full Text
  - Yang, J, Chang, C-Y, Safi, R, Morgan, J, McDonnell, DP, Fuller, PJ, Clyne, CD, and Young, MJ. "Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display." Molecular Endocrinology 25, no. 1 (2011): 32-43. Full Text
  - Kobayashi, S, Stice, JP, Kazmin, D, Wittmann, BM, Kimbrel, EA, Edwards, DP, Chang, C-Y, and McDonnell, DP. "Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer." Mol Endocrinol 24, no. 12 (December 2010): 2292-2302. Full Text Link to Item
  - McDonnell, DP, and Wardell, SE. "The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer." Curr Opin Pharmacol 10, no. 6 (December 2010): 620-628. (Review) Full Text Link to Item
  - Dwyer, MA, Joseph, JD, Wade, HE, Eaton, ML, Kunder, RS, Kazmin, D, Chang, C-Y, and McDonnell, DP. "WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration." Cancer Research 70, no. 22 (November 2010): 9298-9308. Full Text
  - Orr, CR, Montie, HL, Liu, Y, Bolzoni, E, Jenkins, SC, Wilson, EM, Joseph, JD, McDonnell, DP, and Merry, DE. "An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy." The Journal of Biological Chemistry 285, no. 46 (November 2010): 35567-35577. Full Text
  - DuSell, CD, Nelson, ER, Wang, X, Abdo, J, Mödder, UI, Umetani, M, Gesty-Palmer, D, Javitt, NB, Khosla, S, and McDonnell, DP. "The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis." Endocrinology 151, no. 8 (August 2010): 3675-3685. Full Text Link to Item
  - Wade, HE, Kobayashi, S, Eaton, ML, Jansen, MS, Lobenhofer, EK, Lupien, M, Geistlinger, TR, Zhu, W, Nevins, JR, Brown, M, Otteson, DC, and McDonnell, DP. "Multimodal regulation of E2F1 gene expression by progestins." Molecular and Cellular Biology 30, no. 8 (April 2010): 1866-1877. Full Text
  - Muramoto, GG, Russell, JL, Safi, R, Salter, AB, Himburg, HA, Daher, P, Meadows, SK, Doan, P, Storms, RW, Chao, NJ, McDonnell, DP, and Chute, JP. "Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity." Stem Cells 28, no. 3 (March 31, 2010): 523-534. Full Text Link to Item
  - McDonnell, DP. "The homeodomain protein HOXB13 specifies the cellular response to androgens." ENDOCRINE JOURNAL 57 (March 2010): S258-S259. Link to Item
  - Alaynick, WA, Way, JM, Wilson, SA, Benson, WG, Pei, L, Downes, M, Yu, R, Jonker, JW, Holt, JA, Rajpal, DK, Li, H, Stuart, J, McPherson, R, Remlinger, KS, Chang, C-Y, McDonnell, DP, Evans, RM, and Billin, AN. "ERRγ regulates cardiac, gastric, and renal potassium homeostasis." Molecular Endocrinology 24, no. 2 (2010): 299-309. Full Text
  - Chute, JP, Ross, JR, and McDonnell, DP. "Minireview: Nuclear receptors, hematopoiesis, and stem cells." Molecular Endocrinology (Baltimore, Md.) 24, no. 1 (January 2010): 1-10. (Review) Full Text
  - DuSell, CD, Nelson, ER, Wittmann, BM, Fretz, JA, Kazmin, D, Thomas, RS, Pike, JW, and McDonnell, DP. "Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators." Mol Endocrinol 24, no. 1 (January 2010): 33-46. Full Text Link to Item
  - Hall, JM, Barhoover, MA, Kazmin, D, McDonnell, DP, Greenlee, WF, and Thomas, RS. "Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation." Molecular Endocrinology 24, no. 2 (2010): 359-369. Full Text
  - Zhou, XE, Suino-Powell, K, Ludidi, PL, McDonnell, DP, and Xu, HE. "Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs." Protein Expression and Purification 71, no. 1 (2010): 21-27. Full Text
  - Norris, JD, Chang, C-Y, Wittmann, BM, Kunder, RS, Cui, H, Fan, D, Joseph, JD, and McDonnell, DP. "The homeodomain protein HOXB13 regulates the cellular response to androgens." Mol Cell 36, no. 3 (November 13, 2009): 405-416. Full Text Link to Item
  - Frigo, DE, Sherk, AB, Wittmann, BM, Norris, JD, Wang, Q, Joseph, JD, Toner, AP, Brown, M, and McDonnell, DP. "Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro." Molecular Endocrinology (Baltimore, Md.) 23, no. 9 (September 2009): 1385-1396. Full Text
  - Grasfeder, LL, Gaillard, S, Hammes, SR, Ilkayeva, O, Newgard, CB, Hochberg, RB, Dwyer, MA, Chang, C-Y, and McDonnell, DP. "Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha." Mol Endocrinol 23, no. 8 (August 2009): 1171-1182. Full Text Link to Item
  - Joseph, JD, Wittmann, BM, Dwyer, MA, Cui, H, Dye, DA, McDonnell, DP, and Norris, JD. "Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists." Proc Natl Acad Sci U S A 106, no. 29 (July 21, 2009): 12178-12183. Full Text Link to Item
  - Norris, JD, Joseph, JD, Sherk, AB, Juzumiene, D, Turnbull, PS, Rafferty, SW, Cui, H, Anderson, E, Fan, D, Dye, DA, Deng, X, Kazmin, D, Chang, C-Y, Willson, TM, and McDonnell, DP. "Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands." Chem Biol 16, no. 4 (April 24, 2009): 452-460. Full Text Link to Item
  - Stein, RA, Gaillard, S, and McDonnell, DP. "Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells." The Journal of Steroid Biochemistry and Molecular Biology 114, no. 1-2 (March 3, 2009): 106-112. Full Text
  - Wardell, SE, Ilkayeva, OR, Wieman, HL, Frigo, DE, Rathmell, JC, Newgard, CB, and McDonnell, DP. "Glucose metabolism as a target of histone deacetylase inhibitors." Mol Endocrinol 23, no. 3 (March 2009): 388-401. Full Text Link to Item
  - Safi, R, Muramoto, GG, Salter, AB, Meadows, S, Himburg, H, Russell, L, Daher, P, Doan, P, Leibowitz, MD, Chao, NJ, McDonnell, DP, and Chute, JP. "Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture." Mol Endocrinol 23, no. 2 (February 2009): 188-201. Full Text Link to Item
  - Clyne, CD, Chang, C-Y, Safi, R, Fuller, PJ, McDonnell, DP, and Young, MJ. "Purification and characterization of recombinant human mineralocorticoid receptor." Molecular and Cellular Endocrinology 302, no. 1 (2009): 81-85. Full Text
  - Collins, NH, Lessey, EC, DuSell, CD, McDonnell, DP, Fowler, L, Palomino, WA, Illera, MJ, Yu, X, Mo, B, Houwing, AM, and Lessey, BA. "Characterization of antiestrogenic activity of the Chinese herb, Prunella vulgaris, using in vitro and in vivo (mouse xenograft) models (Biology of Reproduction 2009, 80, (375-383) DOI: 10.1095/biolreprod.107.065375)." Biology of Reproduction 80, no. 6 (2009): 1306--. Full Text
  - Collins, NH, Lessey, EC, Dusell, CD, McDonnell, DP, Fowler, L, Palomino, WA, Illera, MJ, Yu, X, Mo, B, Houwing, AM, and Lessey, BA. "Characterization of antiestrogenic activity of the chinese herb, Prunella vulgaris, using in vitro and in vivo (mouse xenograft) models." Biology of Reproduction 80, no. 2 (2009): 375-383. Full Text
  - Stein, RA, Chang, C-Y, Kazmin, DA, Way, J, Schroeder, T, Wergin, M, Dewhirst, MW, and McDonnell, DP. "Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer." Cancer Research 68, no. 21 (November 2008): 8805-8812. Full Text
  - DuSell, CD, and McDonnell, DP. "27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling." Trends Pharmacol Sci 29, no. 10 (October 2008): 510-514. Full Text Link to Item
  - McDonnell, DP. "The commercialism of academic research." Nature Medicine 14, no. 10 (October 2008): 1014-1014. Full Text
  - Sherk, AB, Frigo, DE, Schnackenberg, CG, Bray, JD, Laping, NJ, Trizna, W, Hammond, M, Patterson, JR, Thompson, SK, Kazmin, D, Norris, JD, and McDonnell, DP. "Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic." Cancer Research 68, no. 18 (September 2008): 7475-7483. Full Text
  - Frigo, DE, and McDonnell, DP. "Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation." Molecular Cancer Therapeutics 7, no. 3 (March 2008): 659-669. Full Text
  - DuSell, CD, Umetani, M, Shaul, PW, Mangelsdorf, DJ, and McDonnell, DP. "27-hydroxycholesterol is an endogenous selective estrogen receptor modulator." Molecular Endocrinology (Baltimore, Md.) 22, no. 1 (January 2008): 65-77. Full Text
  - Mettu, NB, Stanley, TB, Dwyer, MA, Jansen, MS, Allen, JE, Hall, JM, and McDonnell, DP. "The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors." Mol Endocrinol 21, no. 10 (October 2007): 2361-2377. Full Text Link to Item
  - Wittmann, BM, Sherk, A, and McDonnell, DP. "Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators." Cancer Res 67, no. 19 (October 1, 2007): 9549-9560. Full Text Link to Item
  - Hall, JM, and McDonnell, DP. "The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages." Mol Endocrinol 21, no. 8 (August 2007): 1756-1768. Full Text Link to Item
  - Zella, LA, Chang, C-Y, McDonnell, DP, and Pike, JW. "The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs." Archives of Biochemistry and Biophysics 460, no. 2 (April 2007): 206-212. Full Text
  - Gaillard, S, Dwyer, MA, and McDonnell, DP. "Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions." Molecular Endocrinology (Baltimore, Md.) 21, no. 1 (January 2007): 62-76. Full Text
  - Heldring, N, Pawson, T, McDonnell, D, Treuter, E, Gustafsson, J-Å, and Pike, ACW. "Structural insights into corepressor recognition by antagonist-bound estrogen receptors." Journal of Biological Chemistry 282, no. 14 (2007): 10449-10455. Full Text
  - Hyatt, SM, Lockamy, EL, Stein, RA, McDonnell, DP, Miller, AB, Orband-Miller, LA, Willson, TM, and Zuercher, WJ. "On the intractability of estrogen-related receptor α as a target for activation by small molecules." Journal of Medicinal Chemistry 50, no. 26 (2007): 6722-6724. Full Text
  - Sherk, AB, and McDonnell, DP. "Molecular pharmacology of estrogen and progesterone receptors." Menopause (2007): 17-28. Full Text
  - Gaillard, S, Grasfeder, LL, Haeffele, CL, Lobenhofer, EK, Chu, T-M, Wolfinger, R, Kazmin, D, Koves, TR, Muoio, DM, Chang, C-Y, and McDonnell, DP. "Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs." Mol Cell 24, no. 5 (December 8, 2006): 797-803. Full Text Link to Item
  - Lu, NZ, Wardell, SE, Burnstein, KL, Defranco, D, Fuller, PJ, Giguere, V, Hochberg, RB, McKay, L, Renoir, J-M, Weigel, NL, Wilson, EM, McDonnell, DP, and Cidlowski, JA. "International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors." Pharmacological Reviews 58, no. 4 (December 2006): 782-797. (Review) Full Text
  - McDonnell, DP. "Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 20, no. 14 (December 2006): 2432-2434. Full Text
  - Stein, RA, and McDonnell, DP. "Estrogen-related receptor alpha as a therapeutic target in cancer." Endocrine Related Cancer 13 Suppl 1 (December 2006): S25-S32. (Review) Full Text
  - Zhang, Y, Ma, K, Sadana, P, Chowdhury, F, Gaillard, S, Wang, F, McDonnell, DP, Unterman, TG, Elam, MB, and Park, EA. "Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression." The Journal of Biological Chemistry 281, no. 52 (December 2006): 39897-39906. Full Text
  - Mettu, NB, Jansen, MS, Dwyer, MA, Hall, JM, Stanley, TB, and McDonnell, DP. "The use of conformational peptide probes to aid in the identification of novel PPAR selective modulators." INFLAMMATION RESEARCH 55 (October 2006): S126-S127. Link to Item
  - Chute, JP, Muramoto, GG, Whitesides, J, Colvin, M, Safi, R, Chao, NJ, and McDonnell, DP. "Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells." Proceedings of the National Academy of Sciences of the United States of America 103, no. 31 (August 2006): 11707-11712. Full Text
  - Noble, SM, Carnahan, VE, Moore, LB, Luntz, T, Wang, H, Ittoop, OR, Stimmel, JB, Davis-Searles, PR, Watkins, RE, Wisely, GB, LeCluyse, E, Tripathy, A, McDonnell, DP, and Redinbo, MR. "Human PXR forms a tryptophan zipper-mediated homodimer." Biochemistry 45, no. 28 (July 2006): 8579-8589. Full Text
  - Kazmin, D, Prytkova, T, Cook, CE, Wolfinger, R, Chu, T-M, Beratan, D, Norris, JD, Chang, C-Y, and McDonnell, DP. "Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators." Molecular Endocrinology (Baltimore, Md.) 20, no. 6 (June 2006): 1201-1217. Full Text
  - Chao, EYH, Collins, JL, Gaillard, S, Miller, AB, Wang, L, Orband-Miller, LA, Nolte, RT, McDonnell, DP, Willson, TM, and Zuercher, WJ. "Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma." Bioorganic & Medicinal Chemistry Letters 16, no. 4 (February 2006): 821-824. Full Text
  - Cidlowski, J, Birnbaumer, M, DeFranco, D, Hunzicker-Dunn, M, McDonnell, D, Pilch, P, Tsai, M-J, and Haworth, M. "Research resource articles - A new feature for Molecular Endocrinology." Molecular Endocrinology 20, no. 9 (2006): 1971--. Full Text
  - Stein, R, Way, JM, McDonnell, DP, and Zuercher, WJ. "Estrogen-related receptor α as a therapeutic target." Drugs of the Future 31, no. 5 (2006): 427-436. Full Text
  - Safi, R, Kovacic, A, Gaillard, S, Murata, Y, Simpson, ER, McDonnell, DP, and Clyne, CD. "Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy." Cancer Res 65, no. 24 (December 15, 2005): 11762-11770. Full Text Link to Item
  - Safi, R, Kovacic, A, Gaillard, S, Murata, Y, Simpson, ER, McDonnell, DP, and Clyne, CD. "Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1 alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy." CANCER RESEARCH 65, no. 24 (December 15, 2005): 11762-11770. Full Text Link to Item
  - Hall, JM, and McDonnell, DP. "Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting." Mol Interv 5, no. 6 (December 2005): 343-357. (Review) Full Text Link to Item
  - Chang, C-Y, Abdo, J, Hartney, T, and McDonnell, DP. "Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display." Mol Endocrinol 19, no. 10 (October 2005): 2478-2490. Full Text Link to Item
  - Chang, C-Y, and McDonnell, DP. "Androgen receptor-cofactor interactions as targets for new drug discovery." Trends Pharmacol Sci 26, no. 5 (May 2005): 225-228. (Review) Full Text Link to Item
  - Wu, Y-L, Yang, X, Ren, Z, McDonnell, DP, Norris, JD, Willson, TM, and Greene, GL. "Structural basis for an unexpected mode of SERM-mediated ER antagonism." Molecular Cell 18, no. 4 (May 2005): 413-424. Full Text
  - Zuercher, WJ, Gaillard, S, Orband-Miller, LA, Chao, EYH, Shearer, BG, Jones, DG, Miller, AB, Collins, JL, McDonnell, DP, and Willson, TM. "Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma." Journal of Medicinal Chemistry 48, no. 9 (May 2005): 3107-3109. Full Text
  - Ortlund, EA, Lee, Y, Solomon, IH, Hager, JM, Safi, R, Choi, Y, Guan, Z, Tripathy, A, Raetz, CRH, McDonnell, DP, Moore, DD, and Redinbo, MR. "Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP." Nature Structural & Molecular Biology 12, no. 4 (April 2005): 357-363. Full Text
  - Shaffer, PL, McDonnell, DP, and Gewirth, DT. "Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor." Biochemistry 44, no. 7 (February 2005): 2678-2685. Full Text
  - Come, SE, Buzdar, AU, Ingle, JN, Arteaga, CL, Brodie, AM, Colditz, GA, Johnston, SRD, Kristensen, VN, Lonning, PE, McDonnell, DP, Osborne, CK, Russo, J, Santen, RJ, Yee, D, and Hart, CS. "Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Conference summary statement." CLINICAL CANCER RESEARCH 11, no. 2 (January 15, 2005): 861S-864S. Link to Item
  - McDonnell, DP. "The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer." Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 871s-877s. (Review) Link to Item
  - Colditz, GA, Ingle, J, Santen, R, Osborne, K, McDonnell, D, Osborne, CK, and Arteaga, C. "Estrogen, estrogen plus progestin therapy, and risk of breast cancer." Clinical Cancer Research 11, no. 2 II (2005): 909s-917s.
  - Come, SE, Buzdar, AU, Ingle, JN, Arteaga, CL, Brodie, AM, Colditz, GA, Johnston, SRD, Kristensen, VN, Lønning, PE, McDonnell, DP, Osborne, CK, Russo, J, Santen, RJ, Yee, D, and Hart, CS. "Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Conference summary statement." Clinical Cancer Research 11, no. 2 II (2005): 861s-864s.
  - Juzumiene, D, Chang, C-Y, Fan, D, Hartney, T, Norris, JD, and McDonnell, DP. "Single-step purification of full-length human androgen receptor." Nucl Recept Signal 3 (2005): e001-. Full Text Link to Item
  - Kristensen, VN, Sørlie, T, Geisler, J, Langerød, A, Yoshimura, N, Kåresen, R, Harada, N, Lønning, PE, Børresen-Dale, A-L, Russo, J, Osborne, K, McDonnell, D, Johnston, S, and Santen, R. "Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: Clinical implications." Clinical Cancer Research 11, no. 2 II (2005): 878s-883s.
  - McDonnell, DP, Yee, D, Santen, R, Osborne, K, and Brodie, A. "The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer." Clinical Cancer Research 11, no. 2 II (2005): 871s-877s.
  - Solomon, IH, Hager, JM, Safi, R, McDonnell, DP, Redinbo, MR, and Ortlund, EA. "Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity." Journal of Molecular Biology 354, no. 5 (2005): 1091-1102. Full Text
  - Yue, W, Wang, J-P, Li, Y, Bocchinfuso, WP, Korach, KS, Devanesan, PD, Rogan, E, Cavalieri, E, and Santen, RJ. "Tamoxifen versus aromatase inhibitors for breast cancer prevention." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 11, no. 2 Pt 2 (January 2005): 925s-930s. (Review)
  - McDonnell, DP. "The molecular determinants of estrogen receptor pharmacology." Maturitas 48 Suppl 1 (August 30, 2004): S7-12. (Review) Full Text Link to Item
  - Shao, W, Keeton, EK, McDonnell, DP, and Brown, M. "Coactivator AIB1 links estrogen receptor transcriptional activity and stability." Proceedings of the National Academy of Sciences of the United States of America 101, no. 32 (August 2, 2004): 11599-11604. Full Text
  - Jansen, MS, Nagel, SC, Miranda, PJ, Lobenhofer, EK, Afshari, CA, and McDonnell, DP. "Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition." Proceedings of the National Academy of Sciences of the United States of America 101, no. 18 (May 2004): 7199-7204. Full Text
  - Turgeon, JL, McDonnell, DP, Martin, KA, and Wise, PM. "Hormone therapy: physiological complexity belies therapeutic simplicity." Science (New York, N.Y.) 304, no. 5675 (May 2004): 1269-1273. (Review) Full Text
  - Glass, CK, and McDonnell, DP. "The Jensen Symposium: A tribute to a pioneer in the field of nuclear receptor biology." Molecular Cell 13, no. 4 (2004): 459-467. Full Text
  - Kurebayashi, S, Nakajima, T, Kim, S-C, Chang, C-Y, McDonnell, DP, Renaud, J-P, and Jetten, AM. "Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORγ." Biochemical and Biophysical Research Communications 315, no. 4 (2004): 919-927. Full Text
  - McDonnell, DP. "E10. Interpreting the results of the women's health initiative within the context of our current understanding of oestrogen and progesterone action." European Journal of Cancer, Supplement 2, no. 9 SPEC. ISS. (2004): 35-40. Full Text
  - Tirado, OM, Selva, DM, Toran, N, Suarez-Quian, CA, Jansen, M, McDonnell, DP, Reventos, J, and Munell, F. "Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration." JOURNAL OF ANDROLOGY 25, no. 1 (2004): 84-94. Link to Item
  - Tirado, OM, Selva, DM, Toràn, N, Suárez-Quian, CA, Jansen, M, McDonnell, DP, Reventós, J, and Munell, F. "Increased Expression of Estrogen Receptor β in Pachytene Spermatocytes after Short-Term Methoxyacetic Acid Administration." Journal of Andrology 25, no. 1 (2004): 84-94.
  - Sathya, G, Chang, C-Y, Kazmin, D, Cook, CE, and McDonnell, DP. "Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion." Cancer Res 63, no. 22 (November 15, 2003): 8029-8036. Link to Item
  - McDonnell, DP. "Mining the complexities of the estrogen signaling pathways for novel therapeutics." Endocrinology 144, no. 10 (October 2003): 4237-4240. (Review) Full Text Link to Item
  - Herrington, DM, Howard, TD, Brosnihan, B, Hawkins, GA, Reboussin, DM, Xu, JF, Zheng, SQL, Meyers, DA, Bleeker, ER, McDonnell, DP, and Li, XL. "Randomized controlled trial evidence that estrogen replacement therapy reduces the progression of subclinical atherosclerosis in healthy postmenopausal women without preexisting cardiovascular disease - Response." CIRCULATION 108, no. 1 (July 8, 2003): E5-E5. Link to Item
  - Rincavage, HL, McDonnell, DP, and Kuhn, CM. "Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells." Endocrinology 144, no. 7 (July 2003): 2829-2835. Full Text
  - Pike, JW, Pathrose, P, Barmina, O, Chang, C-Y, McDonnell, DP, Yamamoto, H, and Shevde, NK. "Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription." Journal of Cellular Biochemistry 88, no. 2 (February 2003): 252-258. Full Text
  - Chang, C-Y, Norris, JD, Jansen, M, Huang, H-J, and McDonnell, DP. "Application of random peptide phage display to the study of nuclear hormone receptors." Methods in Enzymology 364 (January 2003): 118-142. Full Text
  - Kimbrel, EA, and McDonnell, DP. "Function and mode of action of nuclear receptors: Estrogen, progesterone, and vitamin D." Pure and Applied Chemistry 75, no. 11-12 (2003): 1671-1683.
  - McDonnell, DP, and Miranda, P. "The impact of the women's health initiative on the search for improved treatments for the conditions associated with long-term oestrogen deprivation." Journal of the British Menopause Society 9, no. SUPPL. 2 (2003): 4-10.
  - Pike, JW, Pathrose, P, Barmina, O, Chang, C-Y, McDonnell, DP, Yamamoto, H, and Shevde, NK. "Synthetic LXXLL peptides antagonize 1,25-dihydroxyvitamin D₃-dependent transcription." Journal of Cellular Biochemistry 88, no. 2 (2003): 252-258. Full Text
  - Safe, SH, Pallaroni, L, Yoon, K, Gaido, K, Ross, S, and McDonnell, D. "Problems for risk assessment of endocrine-active estrogenic compounds." Environmental Health Perspectives 110 Suppl 6 (December 2002): 925-929. (Review) Full Text
  - Huang, H-J, Norris, JD, and McDonnell, DP. "Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists." Molecular Endocrinology (Baltimore, Md.) 16, no. 8 (August 2002): 1778-1792. Full Text
  - Sathya, G, Jansen, MS, Nagel, SC, Cook, CE, and McDonnell, DP. "Identification and Characterization of Novel Estrogen Receptor-β-Sparing Antiprogestins." Endocrinology 143, no. 8 (August 2002): 3071-3082.
  - Sathya, G, Jansen, MS, Nagel, SC, Cook, CE, and McDonnell, DP. "Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins." Endocrinology 143, no. 8 (August 2002): 3071-3082. Full Text
  - McDonnell, DP, Wijayaratne, A, Chang, C-Y, and Norris, JD. "Elucidation of the molecular mechanism of action of selective estrogen receptor modulators." Am J Cardiol 90, no. 1A (July 3, 2002): 35F-43F. (Review) Link to Item
  - McDonnell, DP, Wijayaratne, A, Chang, CY, and Norris, JD. "Elucidation of the molecular mechanism of action of selective estrogen receptor modulators." AMERICAN JOURNAL OF CARDIOLOGY 90, no. 1 (July 3, 2002): 35F-43F. Full Text Link to Item
  - Li, X, Kimbrel, EA, Kenan, DJ, and McDonnell, DP. "Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation." Molecular Endocrinology (Baltimore, Md.) 16, no. 7 (July 2002): 1482-1491. Full Text
  - Li, X, and McDonnell, DP. "The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT." Molecular and Cellular Biology 22, no. 11 (June 2002): 3663-3673. Full Text
  - McDonnell, DP, and Norris, JD. "Connections and regulation of the human estrogen receptor." Science (New York, N.Y.) 296, no. 5573 (May 2002): 1642-1644. (Review) Full Text
  - Chang, C-Y, and McDonnell, DP. "Evaluation of ligand-dependent changes in AR structure using peptide probes." Molecular Endocrinology (Baltimore, Md.) 16, no. 4 (April 2002): 647-660. Full Text
  - Hall, JM, McDonnell, DP, and Korach, KS. "Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements." Molecular Endocrinology (Baltimore, Md.) 16, no. 3 (March 2002): 469-486. Full Text
  - Norris, JD, Fan, D, Sherk, A, and McDonnell, DP. "A negative coregulator for the human ER." Molecular Endocrinology (Baltimore, Md.) 16, no. 3 (March 2002): 459-468. Full Text
  - Weatherman, RV, Chang, C-Y, Clegg, NJ, Carroll, DC, Day, RN, Baxter, JD, McDonnell, DP, Scanlan, TS, and Schaufele, F. "Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer." Molecular Endocrinology (Baltimore, Md.) 16, no. 3 (March 2002): 487-496. Full Text
  - Herrington, DM, Howard, TD, Brosnihan, KB, McDonnell, DP, Li, X, Hawkins, GA, Reboussin, DM, Xu, J, Zheng, SL, Meyers, DA, and Bleecker, ER. "Common Estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein." Circulation 105, no. 16 (2002): 1879-1882. Full Text
  - McDonnell, DP, Connor, CE, Wijayaratne, A, Chang, C-Y, and Norris, JD. "Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators." Recent Progress in Hormone Research 57 (January 2002): 295-316. (Review) Full Text
  - McDonnell, DP, Wijayaratne, A, Chang, C-Y, and Norris, JD. "Elucidation of the molecular mechanism of action of selective estrogen receptor modulators." American Journal of Cardiology 90, no. 1 SUPPL. 1 (2002): 35F-43F.
  - Pathrose, P, Barmina, O, Chang, C-Y, McDonnell, DP, Shevde, NK, and Pike, JW. "Inhibition of 1,25-dihydroxyvitamin D₃-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors." Journal of Bone and Mineral Research 17, no. 12 (2002): 2196-2205.
  - Chang, CY, Walther, PJ, and McDonnell, DP. "Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer." Cancer Res 61, no. 24 (December 15, 2001): 8712-8717. Link to Item
  - McDonnell, DP, Chang, CY, and Norris, JD. "Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM." Ann N Y Acad Sci 949 (December 2001): 16-35. Link to Item
  - Nagel, SC, Hagelbarger, JL, and McDonnell, DP. "Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics." Endocrinology 142, no. 11 (November 2001): 4721-4728. Full Text
  - Pathrose, P, Chang, CY, McDonnell, DP, and Pike, JW. "Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic peptide antagonists that target the activation domain of retinoid X receptor." JOURNAL OF BONE AND MINERAL RESEARCH 16 (September 2001): S184-S184. Link to Item
  - Wijayaratne, AL, and McDonnell, DP. "The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators." The Journal of Biological Chemistry 276, no. 38 (September 2001): 35684-35692. Full Text
  - Hamilton, MH, Tcherepanova, I, Huibregtse, JM, and McDonnell, DP. "Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates." J Biol Chem 276, no. 28 (July 13, 2001): 26324-26331. Full Text Link to Item
  - McDonnell, DP, Connor, CE, Hall, J, Chang, CY, Jansen, MS, and Norris, JD. "The molecular pharmacology of estrogen receptor agonists, antagonists and SERMs." BONE 28, no. 5 (May 2001): S68-S68. Link to Item
  - Connor, CE, Norris, JD, Broadwater, G, Willson, TM, Gottardis, MM, Dewhirst, MW, and McDonnell, DP. "Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor." Cancer Research 61, no. 7 (April 2001): 2917-2922.
  - Norris, JD, Chang, C, and McDonnell, DP. "Estrogen receptor-cofactor interactions as targets for novel drug discovery." Ernst Schering Res Found Workshop , no. 34 (2001): 181-201. (Review) Link to Item
  - Safe, SH, Pallaroni, L, Yoon, K, Gaido, K, Ross, S, Saville, B, and McDonnellc, D. "Toxicology of environmental estrogens." Reproduction, Fertility, and Development 13, no. 4 (January 2001): 307-315. (Review) Full Text
  - Hall, JM, Chang, CY, and McDonnell, DP. "Development of peptide antagonists that target estrogen receptor beta-coactivator interactions." Mol Endocrinol 14, no. 12 (December 2000): 2010-2023. Full Text Link to Item
  - Schaufele, F, Chang, CY, Liu, W, Baxter, JD, Nordeen, SK, Wan, Y, Day, RN, and McDonnell, DP. "Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor." Molecular Endocrinology (Baltimore, Md.) 14, no. 12 (December 2000): 2024-2039. Full Text
  - McDonnell, DP, Chang, CY, and Norris, JD. "Development of peptide antagonists that target estrogen receptor-cofactor interactions." J Steroid Biochem Mol Biol 74, no. 5 (November 30, 2000): 327-335. (Review) Link to Item
  - Gaido, KW, Maness, SC, McDonnell, DP, Dehal, SS, Kupfer, D, and Safe, S. "Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies." Molecular Pharmacology 58, no. 4 (October 2000): 852-858. Full Text
  - Tcherepanova, I, Puigserver, P, Norris, JD, Spiegelman, BM, and McDonnell, DP. "Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1." J Biol Chem 275, no. 21 (May 26, 2000): 16302-16308. Full Text Link to Item
  - Giangrande, PH, Kimbrel, EA, Edwards, DP, and McDonnell, DP. "The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding." Molecular and Cellular Biology 20, no. 9 (May 2000): 3102-3115. Full Text
  - McDonnell, DP. "Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen." J Soc Gynecol Investig 7, no. 1 Suppl (January 2000): S10-S15. (Review) Link to Item
  - Chang, CY, Norris, JD, Grøn, H, Paige, LA, Hamilton, PT, Kenan, DJ, Fowlkes, D, and McDonnell, DP. "Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta." Molecular and Cellular Biology 19, no. 12 (December 1999): 8226-8239. Full Text
  - Gaido, KW, Leonard, LS, Maness, SC, Hall, JM, McDonnell, DP, Saville, B, and Safe, S. "Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors α and β1." Endocrinology 140, no. 12 (December 1999): 5746-5753.
  - Gaido, KW, Leonard, LS, Maness, SC, Hall, JM, McDonnell, DP, Saville, B, and Safe, S. "Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta." Endocrinology 140, no. 12 (December 1999): 5746-5753. Full Text
  - Hall, JM, and McDonnell, DP. "The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1." Endocrinology 140, no. 12 (December 1999): 5566-5578.
  - Hall, JM, and McDonnell, DP. "The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens." Endocrinology 140, no. 12 (December 1999): 5566-5578. Full Text
  - Wijayaratne, AL, Nagel, SC, Paige, LA, Christensen, DJ, Norris, JD, Fowlkes, DM, and McDonnell, DP. "Comparative Analyses of Mechanistic Differences Among Antiestrogens1." Endocrinology 140, no. 12 (December 1999): 5828-5840.
  - Wijayaratne, AL, Nagel, SC, Paige, LA, Christensen, DJ, Norris, JD, Fowlkes, DM, and McDonnell, DP. "Comparative analyses of mechanistic differences among antiestrogens." Endocrinology 140, no. 12 (December 1999): 5828-5840. Full Text
  - Beaudenon, SL, Huacani, MR, Wang, G, McDonnell, DP, and Huibregtse, JM. "Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae." Molecular and Cellular Biology 19, no. 10 (October 1999): 6972-6979. Full Text
  - McDonnell, DP. "The Molecular Pharmacology of SERMs." Trends Endocrinol Metab 10, no. 8 (October 1999): 301-311. Link to Item
  - Norris, JD, Paige, LA, Christensen, DJ, Chang, CY, Huacani, MR, Fan, D, Hamilton, PT, Fowlkes, DM, and McDonnell, DP. "Peptide antagonists of the human estrogen receptor." Science (New York, N.Y.) 285, no. 5428 (July 1999): 744-746. Full Text
  - Tetel, MJ, Giangrande, PH, Leonhardt, SA, McDonnell, DP, and Edwards, DP. "Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo." Molecular Endocrinology (Baltimore, Md.) 13, no. 6 (June 1999): 910-924. Full Text
  - Improta-Brears, T, Whorton, AR, Codazzi, F, York, JD, Meyer, T, and McDonnell, DP. "Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium." Proceedings of the National Academy of Sciences of the United States of America 96, no. 8 (April 1999): 4686-4691. Full Text
  - Paige, LA, Christensen, DJ, Grøn, H, Norris, JD, Gottlin, EB, Padilla, KM, Chang, CY, Ballas, LM, Hamilton, PT, McDonnell, DP, and Fowlkes, DM. "Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta." Proceedings of the National Academy of Sciences of the United States of America 96, no. 7 (March 1999): 3999-4004. Full Text
  - Wagner, BL, Pollio, G, Giangrande, P, Webster, JC, Breslin, M, Mais, DE, Cook, CE, Vedeckis, WV, Cidlowski, JA, and McDonnell, DP. "The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins." Endocrinology 140, no. 3 (March 1999): 1449-1458. Full Text
  - Wagner, BL, Pollio, G, Giangrande, P, Webster, JC, Breslin, M, Mais, DE, Cook, CE, Vedeckis, WV, Cidlowski, JA, and McDonnell, DP. "The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins." Endocrinology 140, no. 3 (March 1999): 1449-1458. Full Text
  - Giangrande, PH, and McDonnell, DP. "The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene." Recent Prog Horm Res 54 (1999): 291-313. (Review) Link to Item
  - Gould, JC, Leonard, LS, Maness, SC, Wagner, BL, Conner, K, Zacharewski, T, Safe, S, McDonnell, DP, and Gaido, KW. "Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol." Molecular and Cellular Endocrinology 142, no. 1-2 (July 1998): 203-214. Full Text
  - Norris, JD, Fan, D, Stallcup, MR, and McDonnell, DP. "Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology." The Journal of Biological Chemistry 273, no. 12 (March 1998): 6679-6688. Full Text
  - Wagner, BL, Norris, JD, Knotts, TA, Weigel, NL, and McDonnell, DP. "The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor." Mol Cell Biol 18, no. 3 (March 1998): 1369-1378. Link to Item
  - McDonnell, DP. "Definition of the molecular mechanism of action of tissue-selective oestrogen-receptor modulators." Biochemical Society Transactions 26, no. 1 (February 1998): 54-60. (Review) Full Text
  - Maness, SC, McDonnell, DP, and Gaido, KW. "Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells." Toxicology and Applied Pharmacology 151, no. 1 (1998): 135-142. Full Text
  - McDonnell, DP. "Wyeth lederle recent advances in conjugated estrogens estrogen action 1998: new insights. new drugs, new issues." International Journal of Fertility and Menopausal Studies 43, no. 4 (1998): 222--.
  - Ramamoorthy, K, Wang, F, Chen, I-C, Safe, S, Norris, JD, McDonnell, DP, Gaido, KW, Bocchinfuso, WP, Korach, KS, Ashby, J, Lefevre, PA, Odum, J, Harris, CA, Routledge, EJ, and Sumpter, JP. "Potency of combined estrogenic pesticides: Synergy between synthetic oestrogens?." Chemtracts 11, no. 4 (1998): 306-308.
  - Giangrande, PH, Pollio, G, and McDonnell, DP. "Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor." J Biol Chem 272, no. 52 (December 26, 1997): 32889-32900. Link to Item
  - Ramamoorthy, K, Vyhlidal, C, Wang, F, Chen, I, Safe, S, McDonnell, DP, Leonard, LS, and Gaido, KW. "Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol." Toxicology and Applied Pharmacology 147, no. 1 (November 1997): 93-100. Full Text
  - Willson, TM, Norris, JD, Wagner, BL, Asplin, I, Baer, P, Brown, HR, Jones, SA, Henke, B, Sauls, H, Wolfe, S, Morris, DC, and McDonnell, DP. "Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone." Endocrinology 138, no. 9 (September 1997): 3901-3911. Full Text
  - Coldham, NG, Dave, M, Sivapathasundaram, S, McDonnell, DP, Connor, C, and Sauer, MJ. "Evaluation of a recombinant yeast cell estrogen screening assay." Environmental Health Perspectives 105, no. 7 (July 1997): 734-742. Full Text
  - Norris, JD, Fan, D, Kerner, SA, and McDonnell, DP. "Identification of a third autonomous activation domain within the human estrogen receptor." Molecular Endocrinology (Baltimore, Md.) 11, no. 6 (June 1997): 747-754. Full Text
  - Ramamoorthy, K, Wang, F, Chen, IC, Norris, JD, McDonnell, DP, Leonard, LS, Gaido, KW, Bocchinfuso, WP, Korach, KS, and Safe, S. "Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism." Endocrinology 138, no. 4 (April 1997): 1520-1527. Full Text
  - Ramamoorthy, K, Wang, F, Chen, IC, Safe, S, Norris, JD, McDonnell, DP, Gaido, KW, Bocchinfuso, WP, and Korach, KS. "Potency of combined estrogenic pesticides." Science 275, no. 5298 (January 17, 1997): 405-406. (Letter) Link to Item
  - Gaido, KW, Leonard, LS, Lovell, S, Gould, JC, Babaï, D, Portier, CJ, and McDonnell, DP. "Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay." Toxicology and Applied Pharmacology 143, no. 1 (1997): 205-212. Full Text
  - Marks, JR, Huper, G, Vaughn, JP, Davis, PL, Norris, J, McDonnell, DP, Wiseman, RW, Futreal, PA, and Iglehart, JD. "BRCA1 expression is not directly responsive to estrogen." Oncogene 14, no. 1 (January 1997): 115-121. Full Text
  - McDonnell, DP, and Norris, JD. "Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone." Osteoporos Int 7 Suppl 1 (1997): S29-S34. (Review) Link to Item
  - Norris, J, Fan, D, and McDonnell, DP. "Erratum: Identification of the sequences within the human coplement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity (Molecular Endocrinology (1996) 10 (1605-1616))." Molecular Endocrinology 11, no. 3 (1997): 341--.
  - Fan, JD, Wagner, BL, and McDonnell, DP. "Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity." Molecular Endocrinology (Baltimore, Md.) 10, no. 12 (December 1996): 1605-1616. Full Text
  - Wagner, BL, Pollio, G, Leonhardt, S, Wani, MC, Lee, DY, Imhof, MO, Edwards, DP, Cook, CE, and McDonnell, DP. "16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity." Proc Natl Acad Sci U S A 93, no. 16 (August 6, 1996): 8739-8744. Link to Item
  - Imhof, MO, and McDonnell, DP. "Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors." Molecular and Cellular Biology 16, no. 6 (June 1996): 2594-2605. Full Text
  - Vegeto, E, Wagner, BL, Imhof, MO, and McDonnell, DP. "The Molecular Pharmacology of Ovarian Steroid Receptors." Vitamins and Hormones 52, no. C (1996): 99-128. Full Text
  - Wagner, BL, Pollio, G, Leonhardt, S, Wani, MC, Lee, DY-W, Imhof, MO, Edwards, DP, Cook, CE, and McDonnell, DP. "16α-Substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity." Proceedings of the National Academy of Sciences of the United States of America 93, no. 16 (1996): 8739-8744. Full Text
  - Norris, J, Fan, D, Aleman, C, Marks, JR, Futreal, PA, Wiseman, RW, Iglehart, JD, Deininger, PL, and McDonnell, DP. "Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers." J Biol Chem 270, no. 39 (September 29, 1995): 22777-22782. Link to Item
  - McDonnell, DP, Dana, SL, Hoener, PA, Lieberman, BA, Imhof, MO, and Stein, RB. "Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor." Ann N Y Acad Sci 761 (June 12, 1995): 121-137. (Review) Link to Item
  - McDonnell, DP, Clemm, DL, Hermann, T, Goldman, ME, and Pike, JW. "Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens." Molecular Endocrinology (Baltimore, Md.) 9, no. 6 (June 1995): 659-669. Full Text
  - McDonnell, DP. "Unraveling the human progesterone receptor signal transduction pathway Insights into antiprogestin action." Trends Endocrinol Metab 6, no. 4 (May 1995): 133-138. Link to Item
  - Clemm, DL, Macy, BL, Santiso-Mere, D, and McDonnell, DP. "Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor." Journal of Steroid Biochemistry and Molecular Biology 53, no. 1-6 (1995): 487-495. Full Text
  - Gardener, J, and McDonnell, D. "Impact of process changes on the physical properties and formability of silver metal oxide contact materials." Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts (1995): 373-380.
  - Wen, DX, and McDonnell, DP. "Advances in our understanding of ligand-activated nuclear receptors." Current Opinion in Biotechnology 6, no. 5 (1995): 582-589.
  - Klein, KO, Baron, J, Colli, MJ, McDonnell, DP, and Cutler, GB. "Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay." The Journal of Clinical Investigation 94, no. 6 (December 1994): 2475-2480. Full Text
  - WEN, DX, XU, YF, MAIS, DE, GOLDMAN, ME, and MCDONNELL, DP. "THE A-ISOFORM AND B-ISOFORM OF THE HUMAN PROGESTERONE-RECEPTOR OPERATE THROUGH DISTINCT SIGNALING PATHWAYS WITHIN TARGET-CELLS." MOLECULAR AND CELLULAR BIOLOGY 14, no. 12 (December 1994): 8356-8364. Full Text Link to Item
  - McDonnell, DP, Clemm, DL, and Imhof, MO. "Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors." Semin Cancer Biol 5, no. 5 (October 1994): 327-336. (Review) Link to Item
  - Dana, SL, Hoener, PA, Wheeler, DA, Lawrence, CB, and McDonnell, DP. "Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells." Molecular Endocrinology (Baltimore, Md.) 8, no. 9 (September 1994): 1193-1207. Full Text
  - Tai, PK, Albers, MW, McDonnell, DP, Chang, H, Schreiber, SL, and Faber, LE. "Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506." Biochemistry 33, no. 35 (September 1994): 10666-10671. Full Text
  - Crombie, DL, Mukherjee, R, McDonnell, DP, Hayes, JS, and Wang, M-W. "Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment." Journal of Steroid Biochemistry and Molecular Biology 49, no. 2-3 (1994): 123-129. Full Text
  - Dana, SL, Hoener, PA, Wheeler, DA, Lawrence, CB, and McDonnell, DP. "Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells." Molecular Endocrinology 8, no. 9 (1994): 1193-1207. Full Text
  - Kepa, JK, Neeley, CI, Jacobsen, BM, Bruder, JM, McDonnell, DP, Leslie, KK, and Wierman, ME. "Estrogen receptor mediated repression of rat gonadotropin releasing hormone (GnRH) promoter activity in hypothalamic cells." Endocrine 2, no. 10 (1994): 947-956.
  - McDonnell, D. "Comparison of the switching behavior of internally oxidized and powder metallurgical silver metal oxide contact materials." Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts (1994): 253-260.
  - McDonnell, DP, Shahbaz, MM, Vegeto, E, and Goldman, ME. "The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional acitivity." Journal of Steroid Biochemistry and Molecular Biology 48, no. 5-6 (1994): 425-432. Full Text
  - McDonnell, DP, and Goldman, ME. "RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism." Journal of Biological Chemistry 269, no. 16 (1994): 11945-11949.
  - Mukherjee, R, Jow, L, Noonan, D, and McDonnell, DP. "Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators." Journal of Steroid Biochemistry and Molecular Biology 51, no. 3-4 (1994): 157-166. Full Text
  - Tzukerman, MT, Esty, A, Santiso-Mere, D, Danielian, P, Parker, MG, Stein, RB, Pike, JW, and McDonnell, DP. "Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions." Molecular Endocrinology 8, no. 1 (January 1, 1994): 21-30. Full Text
  - Tzukerman, MT, Esty, A, Santiso-Mere, D, Danielian, P, Parker, MG, Stein, RB, Pike, JW, and McDonnell, DP. "Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions." Molecular Endocrinology (Baltimore, Md.) 8, no. 1 (January 1994): 21-30. Full Text
  - Wen, DX, Xu, Y-F, Mais, DE, Goldman, ME, and Mcdonnell, DP. "The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells." Molecular and Cellular Biology 14, no. 12 (1994): 8356-8364.
  - Vegeto, E, Shahbaz, MM, Wen, DX, Goldman, ME, O'Malley, BW, and McDonnell, DP. "Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function." Molecular Endocrinology (Baltimore, Md.) 7, no. 10 (October 1993): 1244-1255. Full Text
  - Poletti, A, Conneely, OM, McDonnell, DP, Schrader, WT, O'Malley, BW, and Weigel, NL. "Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites." Biochemistry 32, no. 37 (September 1993): 9563-9569. Full Text
  - Santiso-Mere, D, Sone, T, Hilliard, GM, Pike, JW, and McDonnell, DP. "Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems." Molecular Endocrinology (Baltimore, Md.) 7, no. 7 (July 1993): 833-839. Full Text
  - Andrews, E, Jansen, R, Crane, AM, Cholin, S, McDonnell, D, and Ledley, FD. "Expression of recombinant human methylmalonyl-CoA mutase: In primary mut fibroblasts and Saccharomyces cerevisiae." Biochemical Medicine and Metabolic Biology 50, no. 2 (1993): 135-144. Full Text
  - McDonnell, D, Gardener, J, and Gondusky, J. "Comparison of the switching behavior of silver metal oxide contact materials." Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts (1993): 37-43.
  - McDonnell, DP, Clevenger, B, Dana, S, Santiso-Mere, D, Tzukerman, MT, and Gleeson, MAG. "The mechanism of action of steroid hormones: A new twist to an old tale." Journal of Clinical Pharmacology 33, no. 12 (1993): 1165-1172.
  - McDonnell, DP, Vegeto, E, and Gleeson, MAG. "Nuclear hormone receptors as targets for new drug discovery." Nature Biotechnology 11, no. 11 (1993): 1256-1261.
  - Nawaz, Z, Stancel, GM, McDonnell, DP, and Hyder, SM. "Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis?." Molecular Carcinogenesis 7, no. 2 (January 1993): 76-82. Full Text
  - Vegeto, E, Shahbaz, MM, Wen, DX, Goldman, ME, O'Malley, BW, and McDonnell, DP. "Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function." Molecular Endocrinology 7, no. 10 (1993): 1244-1255. Full Text
  - Pham, TA, Hwung, YP, Santiso-Mere, D, McDonnell, DP, and O'Malley, BW. "Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast." Molecular Endocrinology (Baltimore, Md.) 6, no. 7 (July 1992): 1043-1050. Full Text
  - Wooge, CH, Nilsson, GM, Heierson, A, McDonnell, DP, and Katzenellenbogen, BS. "Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells." Molecular Endocrinology (Baltimore, Md.) 6, no. 6 (June 1992): 861-869. Full Text
  - Pham, TA, McDonnell, DP, Tsai, MJ, and O'Malley, BW. "Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes." Biochemistry 31, no. 5 (February 1992): 1570-1578. Full Text
  - Fuqua, SAW, Fitzgerald, SD, Allred, DC, Elledge, RM, Nawaz, Z, McDonnell, DP, O'Malley, BW, Greene, GL, and McGuire, WL. "Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors." Cancer Research 52, no. 2 (1992): 483-486.
  - Hyder, SM, Stancel, GM, Nawaz, Z, McDonnell, DP, and Loose-Mitchell, DS. "Identification of an estrogen response element in the 3′-flanking region of the murine c-fos protooncogene." Journal of Biological Chemistry 267, no. 25 (1992): 18047-18054.
  - McDonnell, DP, Vegeto, E, and O'Malley, BW. "Identification of a negative regulatory function for steroid receptors." Proceedings of the National Academy of Sciences of the United States of America 89, no. 22 (1992): 10563-10567. Full Text
  - Nawaz, Z, Tsai, MJ, McDonnell, DP, and O'Malley, BW. "Identification of novel steroid-response elements." Gene Expression 2, no. 1 (January 1992): 39-47.
  - Pham, TA, Hwung, Y-P, Santiso-Mere, D, McDonnell, DP, and O'Malley, BW. "Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast." Molecular Endocrinology 6, no. 7 (1992): 1043-1050. Full Text
  - Poletti, A, Weigel, NL, McDonnell, DP, Schrader, WT, O'Malley, BW, and Conneely, OM. "A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPR_A, in Saccharomyces cerevisiae." Gene 114, no. 1 (1992): 51-58.
  - Vegeto, E, Allan, GF, Schrader, WT, Tsai, M-J, McDonnell, DP, and O'Malley, BW. "The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor." Cell 69, no. 4 (1992): 703-713. Full Text
  - Wooge, CH, Nilsson, GM, Heierson, A, McDonnell, DP, and Katzenellenbogen, BS. "Structural requirements for high affinity ligand binding by estrogen receptors: A comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells." Molecular Endocrinology 6, no. 6 (1992): 861-869. Full Text
  - Fuqua, SAW, Fitzgerald, SD, Chamness, GC, Tandon, AK, McDonnell, DP, Nawaz, Z, O'Malley, BW, and McGuire, WL. "Variant human breast tumor estrogen receptor with constitutive transcriptional activity." Cancer Research 51, no. 1 (1991): 105-109.
  - McDonnell, DP, Nawaz, Z, Densmore, C, Weigel, NL, Pham, TA, Clark, JH, and O'Malley, BW. "High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae." Journal of Steroid Biochemistry and Molecular Biology 39, no. 3 (1991): 291-297.
  - McDonnell, DP, Nawaz, Z, and O'Malley, BW. "In situ distinction between steroid receptor binding and transactivation at a target gene." Molecular and Cellular Biology 11, no. 9 (1991): 4350-4355.
  - Pham, TA, Elliston, JF, Nawaz, Z, Mcdonnell, DP, Tsai, M-J, and O'Malley, BW. "Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers." Proceedings of the National Academy of Sciences of the United States of America 88, no. 8 (1991): 3125-3129.
  - Pham, TA, Hwung, Y-P, McDonnell, DP, and O'Malley, BW. "Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo." Journal of Biological Chemistry 266, no. 27 (1991): 18179-18187.
  - Liao, J, Ozono, K, Sone, T, McDonnell, DP, and Pike, JW. "Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3." Proceedings of the National Academy of Sciences of the United States of America 87, no. 24 (December 1990): 9751-9755. Full Text
  - Power, RF, Conneely, OM, McDonnell, DP, Clark, JH, Butt, TR, Schrader, WT, and O'Malley, BW. "High level expression of a truncated chicken progesterone receptor in Escherichia coli." Journal of Biological Chemistry 265, no. 3 (1990): 1419-1424.
  - Sone, T, McDonnell, DP, O'Malley, BW, and Pike, JW. "Expression of human vitamin D receptor in Saccharomyces cerevisiae: Purification, properties, and generation of polyclonal antibodies." Journal of Biological Chemistry 265, no. 35 (1990): 21997-22002.
  - Hughes, M, Malloy, P, Kieback, D, McDonnell, D, Feldman, D, Pike, JW, and O'Malley, B. "Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets." Advances in experimental medicine and biology 255 (1989): 491-503.
  - Mak, P, McDonnell, DP, Weigel, NL, Schrader, WT, and O'Malley, BW. "Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae)." Journal of Biological Chemistry 264, no. 36 (1989): 21613-21618.
  - McDonnell, DP, Pike, JW, Drutz, DJ, Butt, TR, and O'Malley, BW. "Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae." Molecular and Cellular Biology 9, no. 8 (1989): 3517-3523.
  - McDonnell, DP, Scott, RA, Kerner, SA, O'Malley, BW, and Pike, JW. "Functional domains of the human vitamin D₃ receptor regulate osteocalcin gene expression." Molecular Endocrinology 3, no. 4 (1989): 635-644.
  - Baker, AR, McDonnell, DP, Hughes, M, Crisp, TM, Mangelsdorf, DJ, Haussler, MR, Pike, JW, Shine, J, and O'Malley, BW. "Cloning and expression of full-length cDNA encoding human vitamin D receptor." Proceedings of the National Academy of Sciences of the United States of America 85, no. 10 (May 1988): 3294-3298. Full Text
  - Haussler, MR, Mangelsdorf, DJ, Komm, BS, Terpening, CM, Yamaoka, K, Allegretto, EA, Baker, AR, Shine, J, McDonnell, DP, and Hughes, M. "Molecular biology of the vitamin D hormone." Recent progress in hormone research 44 (1988): 263-305.
  - McDonnell, DP, Pike, JW, and O'Malley, BW. "The vitamin d receptor: A primitive steroid receptor related to thyroid hormone receptor." Journal of Steroid Biochemistry 30, no. 1-6 (1988): 41-46.
  - Mangelsdorf, DJ, Komm, BS, McDonnell, DP, Pike, JW, and Haussler, MR. "Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: Assessment of mRNA regulation by the vitamin D hormone." Biochemistry 26, no. 25 (1987): 8332-8338.
  - Maxwell, BL, McDonnell, DP, Conneely, OM, Schulz, TZ, Greene, GL, and O'Malley, BW. "Structural organization and regulation of the chicken estrogen receptor." Molecular endocrinology (Baltimore, Md.) 1, no. 1 (1987): 25-35.
  - McDonnell, DP, Mangelsdorf, DJ, and Pike, JW. "Molecular cloning of complementary DNA encoding the avian receptor for vitamin D." Science 235, no. 4793 (1987): 1214-1217.
  - Lawrence, CB, Mcdonnell, DP, and Ramsey, WJ. "Analysis of repetitive sequence elements containing tRNA-like sequences." Nucleic Acids Research 13, no. 12 (1985): 4239-4252. Full Text
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles

Recent Courses