Overview
Current Appointments & Affiliations
Associate Research Professor of Pharmacology and Cancer Biology
·
2012 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Recent Publications
7993 Thienopyrimidine-Based Estrogen Receptor Modulators Adopt Unique Ligand Binding Poses to Elicit Anti-Proliferative Activities in ER+ Breast Cancer Cells
Conference Journal of the Endocrine Society · October 5, 2024 AbstractDisclosure: E.C. Fink: None. S.L. Mateus: None. N. Meganathan: None. V.K. Sammeta: None. J.D. Norris: None. D.P. McDonnell: None. T. Willson: None. S.W. Fanning: None. Full text CiteAndrogen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.
Journal Article Nat Commun · September 3, 2024 Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the androgen signaling axis remains the go ... Full text Link to item CiteThe Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide.
Conference Clin Cancer Res · March 15, 2024 PURPOSE: HOXB13 is an androgen receptor (AR) coregulator specifically expressed in cells of prostatic lineage. We sought to associate circulating tumor cell (CTC) HOXB13 expression with outcomes in men with mCRPC treated with abiraterone or enzalutamide. E ... Full text Link to item CiteRecent Grants
Manipulating normal estrogen physiology as a therapeutic approach in cancer
ResearchAssociate Research Professor · Awarded by National Cancer Institute · 2023 - 2028Elucidation of the mechanisms by which cells recognize and respond to different levels of androgens
ResearchAssociate Research Professor · Awarded by National Institutes of Health · 2022 - 2027HOXB13 as a therapeutic target in prostate cancer
ResearchAssociate Research Professor · Awarded by Prostate Cancer Foundation · 2020 - 2024View All Grants
Education, Training & Certifications
National University of Ireland (Ireland) ·
1998
Ph.D.