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John David Norris

Associate Research Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
Duke Box 3813, Durham, NC 27710
Research Drive, LSRC Bldg, C251, Durham, NC 27710

Overview


Molecular pharmacology of the nucler receptor class of transcription factors. Special interest in the mode of action of tissue specific ligands for the estrogen and androgen receptors.

Current Appointments & Affiliations


Associate Research Professor of Pharmacology and Cancer Biology · 2012 - Present Pharmacology & Cancer Biology, Basic Science Departments

Recent Publications


7993 Thienopyrimidine-Based Estrogen Receptor Modulators Adopt Unique Ligand Binding Poses to Elicit Anti-Proliferative Activities in ER+ Breast Cancer Cells

Conference Journal of the Endocrine Society · October 5, 2024 AbstractDisclosure: E.C. Fink: None. S.L. Mateus: None. N. Meganathan: None. V.K. Sammeta: None. J.D. Norris: None. D.P. McDonnell: None. T. Willson: None. S.W. Fanning: None. Full text Cite

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.

Journal Article Nat Commun · September 3, 2024 Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the androgen signaling axis remains the go ... Full text Link to item Cite

The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide.

Conference Clin Cancer Res · March 15, 2024 PURPOSE: HOXB13 is an androgen receptor (AR) coregulator specifically expressed in cells of prostatic lineage. We sought to associate circulating tumor cell (CTC) HOXB13 expression with outcomes in men with mCRPC treated with abiraterone or enzalutamide. E ... Full text Link to item Cite
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Recent Grants


Manipulating normal estrogen physiology as a therapeutic approach in cancer

ResearchAssociate Research Professor · Awarded by National Cancer Institute · 2023 - 2028

Elucidation of the mechanisms by which cells recognize and respond to different levels of androgens

ResearchAssociate Research Professor · Awarded by National Institutes of Health · 2022 - 2027

HOXB13 as a therapeutic target in prostate cancer

ResearchAssociate Research Professor · Awarded by Prostate Cancer Foundation · 2020 - 2024

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Education, Training & Certifications


National University of Ireland (Ireland) · 1998 Ph.D.